Protein Alignment sev and Btk

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 725
• Identity: 187/725 - (25%)
• Similarity: 292/725 - (40%)
• Gaps: 168/725 - (23%)

  Fly  1832 YTLHWQQELDGENVQDRREW-EAHERRLETAGTHRLTGIKPG----------SGYSL-------- 1877
            |||:    :...:.::|.|| .|..:..|.:.|.:.....||          .|.|.
  Fly   160 YTLY----VIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAA 220

  Fly  1878 --WVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQL 1940
              |.:|:..|:..:|..:...||           :.|.|      .|.:...|||   .:|:..|
  Fly   221 AHWREANNNPSNGSSPAQNSTRS-----------ISPNS------STTNSQFSLQ---HNSSGSL 265

  Fly  1941 RRNV---------------AGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLG 1990
            ...|               .|.........|||::.     |..:..:|.....:||.......|
  Fly   266 GGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSS-----LTTFKQSPTLLNGNGTLLDANMPG 325

  Fly  1991 DAPSQPGKPQLEHIAEEVFRVTWTAARGNG----APIALYNLEALQARSDIRRRRRRRRRNSGGS 2051
            ..|: ||.|.             :.|:.|.    ..:|||..:|::                ||.
  Fly   326 GIPT-PGTPN-------------SKAKDNSHFVKLVVALYPFKAIE----------------GGD 360

  Fly  2052 LEQLPWAEEPVVVEDQ---WLDFCNTTELSCIVKSLHSSRLLLFRVRARSLE-HGWGPYSEESER 2112
            |.....||..|:.:.|   |........:..|..:....:.||      .|| :.|.......:|
  Fly   361 LSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALL------GLERYEWYVGDMSRQR 419

  Fly  2113 VAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIW-SNLSTLQ 2176
            ........:|.|..|:...:...:.:     |.|..||.:..::...:.|.:|...: |.....:
  Fly   420 AESLLKQGDKEGCFVVRKSSTKGLYT-----LSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCE 479

  Fly  2177 TQQQL----------MAVRNRAFSTTLSDADIALLP---------QINWSQLKLLRFLGSGAFGE 2222
            |...|          :|.|.::     |..|..:.|         :|:..:|.|:..||||.||.
  Fly   480 TIPDLINYHRHNSGGLACRLKS-----SPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGV 539

  Fly  2223 V----YEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESIS 2283
            |    :.|.:.|         |:|.:::|.....:.::||::|:..:|.|:|.|.|:|.....|.
  Fly   540 VRRGKWRGSIDT---------AVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIY 595

  Fly  2284 LIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRN 2348
            ::.|:|:.|.||:|||....|...        ::..||.|||.|:.|.:|||..:::|||||.||
  Fly   596 IVTEYMKHGSLLNYLRRHEKTLIG--------NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARN 652

  Fly  2349 CLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAF 2413
            |||    ||   ...||:.||||||.:. .|.|...|....|::|..||.|....|:::|||||:
  Fly   653 CLV----GS---ENVVKVADFGLARYVL-DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAY 709

  Fly  2414 GVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCY 2478
            |||.|||.|.|:.||....|.||:..|:.|..|::|..|.:::|.::.|||...|.|||:||...
  Fly   710 GVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLM 774

  Fly  2479 NTLHAISTDL 2488
            :.|..::..|
  Fly   775 DQLALVAQTL 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	16/79 (20%)
		FN3	1993..2111	CDD:238020	24/125 (19%)
		PTKc_c-ros	2213..2483	CDD:270640	104/273 (38%)
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	13/65 (20%)
		SH3_Tec_like	346..399	CDD:212702	13/68 (19%)
		SH2_Tec_family	403..505	CDD:198188	20/117 (17%)
		PTKc_Tec_like	521..778	CDD:173637	106/281 (38%)