DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and MALRD1

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_011517755.1 Gene:MALRD1 / 340895 HGNCID:24331 Length:2176 Species:Homo sapiens


Alignment Length:1227 Identity:213/1227 - (17%)
Similarity:358/1227 - (29%) Gaps:468/1227 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   757 AGNGPASSHWQSFALL----GRSLLLPDSGQLILVEQQGQAASPSASWPLKNLPDCWAVILLVPE 817
            |..||....||:.|.|    .|:::...|.|...|..:||.||......:..:.|.         
Human   186 ACGGPIQHLWQNTAALPNQWERNVIKIQSSQRFQVVFEGQMASTYEQDEVIAIDDI--------- 241

  Fly   818 SQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIR 882
               ..|:|..|.:...||..:|....                                   |.:.
Human   242 ---SFSSGCLPANDGILLCQEALNAE-----------------------------------RELC 268

  Fly   883 GPIFGLQRLQPDNLYQLRV-RAINVDGEPGEWTEPLAAR--TWPLGPHRLRWASRQGSVIHTNEL 944
            .|...|.|....: .:||: :|...:.:..|||...:|.  :|      :|..:|:.....:.. 
Human   269 HPDTDLCRFDATD-EELRLCQACGFEFDMCEWTSEASAGQISW------MRTKAREIPAFESTP- 325

  Fly   945 GEGLEVQQEQLERLPGPMTMVNESVGYYV------------------TGDGLLHCI-NLVHSQWG 990
                  ||:|          ..:..||||                  ....:.||: ...|.|:.
Human   326 ------QQDQ----------GGDDEGYYVWVGAKHGFTLNHLDSRAYLNSSVCHCLGKSCHLQFY 374

  Fly   991 CPISEPLQHVGSVTYDWRGGRVYWT-DLARNCVVRMDPWSGSRELLP--------VFEA------ 1040
            ..:...:..|.  .|:.:...::|| :::.:     ..|..:..|:|        :||.      
Human   375 YAMESSVLRVR--LYNNKEEEIFWTYNISTH-----SQWVKADVLIPEDLKTFKIIFEGTLLSQR 432

  Fly  1041 NFLALDPRQGHLY-YATSSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDTQQD----------- 1093
            :|:|||    ||: ||.....||...:.||    :.....:......|.|::||           
Human   433 SFIALD----HLWVYACGQTQSRKLCSADE----FPCTSGQCIAKESVCDSRQDCSDESDEDPAT 489

  Fly  1094 ----------------------QLFW-LVKG--SGALRLYRAPLTAGGDSLQMIQQIKGVFQAVP 1133
                                  ...| |:||  :|......|..||..:.               
Human   490 CSKHLTCDFESGFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINH--------------- 539

  Fly  1134 DSLQLLRPLGALLWLERSGRRARLVRLAAPL--DVMELPTPDQA------SPASALQLLDPQPLP 1190
                     |:.::|| :.|...:.:|.:|:  .::...||.|.      |..|.|.:.....|.
Human   540 ---------GSFIYLE-AQRSPGVAKLGSPVLTKLLTASTPCQVQFWYHLSQHSNLSVFTRTSLD 594

  Fly  1191 P--RDEGVIPMTVLPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFA 1253
            .  :.:|.|        :|..:..|.  |.:.......|..::.::|:||     .|:..|....
Human   595 GNLQKQGKI--------IRFSESQWS--HAKIDLIAEAGESTLPFQLILE-----ATVLSSNATV 644

  Fly  1254 RLTQLPQAQ-LQLKISITPRTA---------------------------WRSGDTTRVQLTTPPV 1290
            .|..:..:| .::.....|||:                           |.....:.:.......
Human   645 ALDDISVSQECEISYKSLPRTSTQSKFSKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQ 709

  Fly  1291 APSQPRRLR------VFVERLATALQEANVSAVLRWDAPEQGQEAPMQALE---YHISCWVGS-- 1344
            ||.:...|.      :|:.:.:::|.:     |.:..:|...|..|...|.   |:....||:  
Human   710 APPRDHSLNASQGHFMFILKKSSSLWQ-----VAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAE 769

  Fly  1345 -ELHEE----------LRLNQSA--LEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAP 1396
             :||.|          :..||..  |||.::..:..|.:|..::             ..:|.:..
Human   770 LQLHMENSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLD-------------KVSLGIYD 821

  Fly  1397 EVQAVPRVLYANAEFIGELDLDTRNRRRL-----VHTASPVEHL--------------------- 1435
            .|.|:..:.:.|.    .|.|...:...|     .||.:.:|.|                     
Human   822 GVSAIDDIRFENC----TLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPE 882

  Fly  1436 ------VGI-----EGEQRLLWVNEHVELLTHVPGSAPA-KLARMRAEVLALAVDWIQRIVYWAE 1488
                  .||     :.:....|        |...|..|. ....|:...|..|..      ::..
Human   883 LQCNFETGICNWEQDAKDDFDW--------TRSQGPTPTLNTGPMKDNTLGTAKG------HYLY 933

  Fly  1489 LDATAPQA---------AIIYRLDL--CNFE------GKILQG----ERVWSTPRGRLLKDLVAL 1532
            ::::.|||         .|:...|.  |.|.      ||.:..    :|:||..||:||      
Human   934 IESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLL------ 992

  Fly  1533 PQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLC 1597
                   |..:  |:..|..:|       ..|..::.||...|...|:..|.        .|.:.
Human   993 -------WQIF--GNQGNRWIR-------KHLNISSRQPFQILVEASVGDGF--------TGDIA 1033

  Fly  1598 VYDVARQLCT--ASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEP 1660
            :.|::...||  ...|.|.|....|.|:...|                                 
Human  1034 IDDLSFMDCTLYPGNLPADLPTPPETSVPVTL--------------------------------- 1065

  Fly  1661 EEVRLLQAHNYQAYPPKNC----LLLPSSGGSLLKATDC----------EEQRCLLHLPMITASE 1711
                          ||.||    .:..|.|..:.|...|          :|..|::.:.......
Human  1066 --------------PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRS 1116

  Fly  1712 DC----PLPI------PGVRYQLNLTLAKEPGSEEH----DHGMEPLGQWLLGAGES 1754
            .|    |:|:      ...|:.|...::...|.|.|    ||.......|.|.|..|
Human  1117 LCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSS 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020 15/97 (15%)
LY 993..1026 CDD:214531 4/33 (12%)
FN3 1292..1374 CDD:214495 22/105 (21%)
FN3 1799..1897 CDD:238020
FN3 1993..2111 CDD:238020
Pkinase_Tyr 2209..2481 CDD:285015
PTKc_c-ros 2213..2483 CDD:270640
MALRD1XP_011517755.1 LDLa 58..87 CDD:238060
MAM 93..246 CDD:279023 17/71 (24%)
MAM 93..246 CDD:99706 17/71 (24%)
MAM 290..438 CDD:279023 29/177 (16%)
MAM 290..438 CDD:99706 29/177 (16%)
LDLa 454..485 CDD:197566 6/34 (18%)
MAM 496..655 CDD:279023 34/198 (17%)
MAM 496..652 CDD:99706 33/195 (17%)
MAM 674..836 CDD:279023 28/183 (15%)
MAM 674..833 CDD:99706 27/176 (15%)
LDLa 847..879 CDD:238060 4/31 (13%)
MAM 885..1044 CDD:279023 38/202 (19%)
MAM 885..1041 CDD:99706 37/199 (19%)
LDLa 1070..1105 CDD:238060 6/34 (18%)
MAM 1110..1276 CDD:279023 14/64 (22%)
MAM 1110..1273 CDD:99706 14/64 (22%)
LDLa 1283..1315 CDD:197566
MAM 1327..1483 CDD:279023
MAM 1327..1481 CDD:99706
LDLa 1503..1537 CDD:238060
MAM 1541..1693 CDD:99706
MAM 1541..1691 CDD:279023
LDLa 1704..1739 CDD:238060
MAM 1749..1910 CDD:99706
MAM 1749..1909 CDD:279023
LDLa 1923..1958 CDD:238060
LDLa 1967..2001 CDD:238060
EGF_CA 2044..2076 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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