DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sev and Ltk

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_001101233.2	Gene:	Ltk / 311337	RGDID:	1309323	Length:	577	Species:	Rattus norvegicus

Alignment Length:	359	Identity:	146/359 - (40%)
Similarity:	203/359 - (56%)	Gaps:	27/359 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  2130 IIAPAAIVSSCVLA-------LVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNR 2187
            :|...|:|::..|:       |:||.:.:.:.||..:|     |.....||.|:|.....|....
  Rat   110 LIMMGAVVTALTLSLLMMCGVLILVNQKKCQSLRGTRL-----PGPELELSKLRTSAIRTAPNPY 169

  Fly  2188 AFSTTLSDADIALLPQ----INWSQLKLLRFLGSGAFGEVYEG-QLKTEDSEEPQRVAIKSLRKG 2247
            .....||.|....|||    ::.:.:.|||.||.||||||||| .:.......|..||||:|.:.
  Rat   170 YCQVGLSPAQAWPLPQGLTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLPVAIKTLPEL 234

  Fly  2248 ASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQ 2310
            .|...||  |.||.::|.|.|:|||..||:.|......:::|.|..||:.|:||.:|    ..|.
  Rat   235 CSPQDELDFLMEALIISKFSHQNIVRCVGLSFQAAPRLILLELMSGGDMKSFLRHSR----PHPG 295

  Fly  2311 PTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDI 2375
            ..:.|::.:||.:..|:|.||.|||:.||:|||:|.||||::.|..|    |..||||||:||||
  Rat   296 QLSPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGDS----RVAKIGDFGMARDI 356

  Fly  2376 YKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHV 2440
            |::.||||.|..||||:||.||:|::||||:::|.|:||||.|||.:||..||....|.|||..:
  Rat   357 YQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFI 421

  Fly  2441 KEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSF 2474
            ..|.|:..|..|...:|.::..||:..|..||.|
  Rat   422 ATGNRMDPPRNCPGPVYRIMTQCWQLQPELRPDF 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020
		Pkinase_Tyr	2209..2481	CDD:285015	124/269 (46%)
		PTKc_c-ros	2213..2483	CDD:270640	122/265 (46%)
Ltk	NP_001101233.2	PTKc_ALK_LTK	188..464	CDD:270632	124/276 (45%)
Ltk	NP_001101233.2	Pkinase_Tyr	195..462	CDD:285015	124/269 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27151at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820