Protein Alignment sev and Map3k10

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001382027.1
• Gene: Map3k10 / 308463
• RGDID: 1308381
• Length: 940
• Species: Rattus norvegicus
• Alignment Length: 374
• Identity: 112/374 - (29%)
• Similarity: 167/374 - (44%)
• Gaps: 53/374 - (14%)

  Fly  2197 DIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSL-----RKGASEFAELLQ 2256
            |:.|..:|.:.:|:|...:|.|.||:||....:.|:      ||:|:.     |..|....::.|
  Rat    86 DLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEE------VAVKAARLDPERDPAVTAEQVRQ 144

  Fly  2257 EAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELL 2321
            ||:|....:|.||:.|.|.|....::.|:||:...|.|...|...|...            ..|:
  Rat   145 EARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPP------------HVLV 197

  Fly  2322 AMCIDVANGCSYLED---MHFVHRDLACRNCLVTESTGSTDRRRTV-KIGDFGLARDIYKSDYYR 2382
            ...:.||.|.:||.:   :..:||||...|.|:.|:..:.:...|| ||.||||||:.:|:....
  Rat   198 NWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMS 262

  Fly  2383 KEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQ 2447
            ..|    ...||:||.:...||:..||||:||||.||:|| |:.||   ...:.|| |..|..:.
  Rat   263 AAG----TYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPY---REIDALA-VAYGVAMN 318

  Fly  2448 Q-----PPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRP 2507
            :     |..|.|....||..||..||..||.|......|..|... ...||...:..::....:.
  Rat   319 KLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVIEQS-ALFQMPLESFHSLQEDWKL 382

  Fly  2508 EFKVRFDGQPLEE----HRE-------HNERPEDENLTLREVPLKDKQL 2545
            |.:..||....:|    .||       ..:|.::|.|..||..|.::::
  Rat   383 EIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREM 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020
		PTKc_c-ros	2213..2483	CDD:270640	92/283 (33%)
Map3k10	NP_001382027.1	SH3_MLK1-3	20..76	CDD:212992
		Protein Kinases, catalytic domain	103..360	CDD:473864	92/283 (33%)
		Leucine-zipper 1	384..405		5/20 (25%)
		Leucine-zipper 2	419..440		4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..658
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..732
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..916