DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and HCK

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_002101.2 Gene:HCK / 3055 HGNCID:4840 Length:526 Species:Homo sapiens


Alignment Length:547 Identity:144/547 - (26%)
Similarity:242/547 - (44%) Gaps:114/547 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1971 AATPGAPLYHGTAEVYETLGDAPS--QPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQA 2033
            :|:|..|:|  ..:...|:...|:  ....|.:.....|...|           :|||:.||:. 
Human    43 SASPHCPVY--VPDPTSTIKPGPNSHNSNTPGIREAGSEDIIV-----------VALYDYEAIH- 93

  Fly  2034 RSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVED--QWLDFCNTTELSCIVKSLHSSRLLLFRVRA 2096
            ..|:..::                .::.||:|:  :|.                         :|
Human    94 HEDLSFQK----------------GDQMVVLEESGEWW-------------------------KA 117

  Fly  2097 RSL---EHGWGPYS----EESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLA---------LV 2145
            |||   :.|:.|.:    .:|....|.|.....|......::||..::.|.::.         .:
Human   118 RSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182

  Fly  2146 LVRKVQKRR---LRAKKLLQQSRPSIW-SNLSTLQTQQQLM---AVRNRAFSTTLSDADIALLPQ 2203
            .||....|:   ::..|:........: |..||..|.|:|:   ...|......||...::..||
Human   183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQ 247

  Fly  2204 INWSQ---------LKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQ 2259
            ..|.:         |||.:.||:|.||||:   :.|.:..  .:||:|:::.|:......|.||.
Human   248 KPWEKDAWEIPRESLKLEKKLGAGQFGEVW---MATYNKH--TKVAVKTMKPGSMSVEAFLAEAN 307

  Fly  2260 LMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMC 2324
            :|...:|:.:|.|..: ...|.|.:|.|.|..|.||.:|::...:.    ||     |.:|:...
Human   308 VMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSLLDFLKSDEGSK----QP-----LPKLIDFS 362

  Fly  2325 IDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLL 2389
            ..:|.|.:::|..:::||||...|.||:.|.       ..||.||||||.|..::|..:|| ...
Human   363 AQIAEGMAFIEQRNYIHRDLRAANILVSASL-------VCKIADFGLARVIEDNEYTAREG-AKF 419

  Fly  2390 PVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTE 2454
            |::|.:||::..|.||.:||||:||:|..||:|.|:.||...:|.||:..::.|.|:.:|..|.|
Human   420 PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPE 484

  Fly  2455 KLYSLLLLCWRTDPWERPSFRRCYNTL 2481
            :||::::.||:..|.|||:|....:.|
Human   485 ELYNIMMRCWKNRPEERPTFEYIQSVL 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020 20/128 (16%)
PTKc_c-ros 2213..2483 CDD:270640 93/269 (35%)
HCKNP_002101.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SH3 82..137 CDD:473055 17/107 (16%)
SH2_Src_HCK 140..243 CDD:198226 19/102 (19%)
Protein Kinases, catalytic domain 254..524 CDD:473864 96/281 (34%)
Blue background indicates that the domain is not in the aligned region.

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