DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and ret

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_858048.2 Gene:ret / 30512 ZFINID:ZDB-GENE-980526-307 Length:1106 Species:Danio rerio


Alignment Length:657 Identity:179/657 - (27%)
Similarity:279/657 - (42%) Gaps:144/657 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1947 NHTKMVVEPLQPRTRY-------QCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHI 2004
            |.||::..|......|       |.:|   .|.|.....:.|.|:..:|  |.|..|.      .
Zfish   461 NDTKVLRRPECQELEYVVIAQEQQNKL---QAKTQLTVSFQGEADSLKT--DEPRFPA------C 514

  Fly  2005 AEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWL 2069
            ||:..|....|.||.|||..              |.:.|:.|:.|.|......:.......|.:.
Zfish   515 AEKRQRGDCEATRGLGAPTG--------------RCQWRQGRDKGISKRYSTCSPNLGTCPDGYC 565

  Fly  2070 DFCNTTELSCIVKSLHSSRLL------LFRVRARSLEHGWGP-YSEESERVAEPFVSPEKR--GS 2125
            |...:..:|...:...|..::      |:.::|     |.|. |..|.:...|. ..||..  ..
Zfish   566 DAIESKNISICPQDCSSEAIIGGYERDLYGIKA-----GHGTCYCFEGKCFCER-DEPEDDICND 624

  Fly  2126 LVLAIIAPAAIVS---SCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNR 2187
            :...:||...|:|   |.:|:...:.:..|         ...:|.|.|...|.:...|...:...
Zfish   625 MCKTVIATGIILSFIVSVLLSSYFIHRYHK---------TTPKPPIASAEMTFRRPAQSYPISYS 680

  Fly  2188 AFSTTLSDAD-----IAL----LPQ-INW----SQLKLLRFLGSGAFGEVYEG-QLKTEDSEEPQ 2237
            |.:...:..|     :|:    :|: ..|    ..|.|.:.||.|.||:|.:. ..:.:......
Zfish   681 ANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYT 745

  Fly  2238 RVAIKSLRKGA--SEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLR- 2299
            .||:|.|::.|  ||..:||.|..|:....|.:::.:.|.|.....:.||:|:.:.|.|.::|| 
Zfish   746 TVAVKMLKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRE 810

  Fly  2300 ------------AARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVT 2352
                        |.|.:|..|......|::.:|::....::.|..||.:|..||||||.||.||.
Zfish   811 SRKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVA 875

  Fly  2353 ESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLC 2417
            |.       |.:||.||||:||:|:.|.|.|..:|.:||:||:.|||.|.::|||||||:||||.
Zfish   876 EG-------RKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 933

  Fly  2418 WEILTLGQQPY---AARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYN 2479
            |||:|||..||   |....|.:|   |.|.|:::|..||:::|:|:|.||:.:..:||:|     
Zfish   934 WEIVTLGGNPYPGIAPERLFNLL---KTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTF----- 990

  Fly  2480 TLHAISTDLRRTQM---------ASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENLTL 2535
              ..||.:|.:..:         ||..||.::                          .|::|:.
Zfish   991 --SDISKELEKMMVKSRDYLDLAASTPADALL--------------------------YDDSLSE 1027

  Fly  2536 REVPLKD 2542
            .:.||.|
Zfish  1028 EDTPLVD 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020 26/124 (21%)
PTKc_c-ros 2213..2483 CDD:270640 106/288 (37%)
retNP_858048.2 RET_CLD1 23..140 CDD:465485
CA 186..256 CDD:214520
RET_CLD3 251..364 CDD:465516
RET_CLD4 388..499 CDD:465517 9/40 (23%)
PTKc_RET 715..1004 CDD:173631 111/305 (36%)
Blue background indicates that the domain is not in the aligned region.

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