Protein Alignment sev and T21G5.1

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001355382.1
• Gene: T21G5.1 / 266839
• WormBaseID: WBGene00020659
• Length: 514
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 146/570 - (25%)
• Similarity: 234/570 - (41%)
• Gaps: 134/570 - (23%)

  Fly  1966 LLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARG----NGAPIALY 2026
            :|.|...|.|.. ..|:.|.....|..|....||:...:...|.::| ...:|    :|. |...
 Worm    26 VLPGNGITTGGS-REGSKESANPPGTPPPPEEKPKEPMVDVPVVQIT-PEIKGCQFYHGI-IPRV 87

  Fly  2027 NLE-ALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLL 2090
            :.| :|:...|...||...|.|:||..                                    |:
 Worm    88 DAELSLRYVGDYLLRRAEPRENAGGQF------------------------------------LI 116

  Fly  2091 LFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAII----APAAIVSSCVLALVLVRKVQ 2151
            :...|.....|  .|.|::.|...:.:..|..:.:.||.:|    |.|..|  ||...|.:||..
 Worm   117 ISVKREAGFVH--VPISQDKEGAKQFYFMPTLKENTVLDLIDVHLARAQPV--CVQWNVYLRKPV 177

  Fly  2152 KRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLG 2216
            .|             :.|                              ::|.   ..:.|.|.:|
 Worm   178 LR-------------ATW------------------------------IIPH---EDVILYRKIG 196

  Fly  2217 SGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLM-SNFKHENIVCLVGICFD 2278
            |||||||:..::....||.....|:|.|::.|:..|:|  ::||::| .|:||::||.:.||...
 Worm   197 SGAFGEVFLARMVDPTSEYVLDCAVKKLKQEATMDAKLRFMKEARMMLKNYKHKHIVMIFGIATL 261

  Fly  2279 TESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRD 2343
            ...:.::||....|.|:||||..:...|          |.|.|....:.::|.:|||.|..:|||
 Worm   262 NSPLLILMELCPNGSLISYLRKNKGKVT----------LLEKLRFSAEASSGLAYLEKMECIHRD 316

  Fly  2344 LACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKS---DYYRKEGEGLLPVRWMSPESLVDGLFT 2405
            :|.||||::       .:..:||.|.|||.|  |.   ||...:    ||::|::||.:.|.:::
 Worm   317 IAARNCLLS-------AKNEIKISDLGLADD--KGMVIDYSLDK----LPIKWLAPEIMQDKVYS 368

  Fly  2406 TQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAH-VKEGGRLQQPPMCTEKLYSLLLLCWRTDPW 2469
            .:||:||||::.|||...|.:||...||.:..|. |....|::.|.....:|..::..||:.||.
 Worm   369 LKSDIWAFGIMIWEIFAEGDEPYPGLNNTQARAKIVVLDYRMKFPDEAPTELVQVIDTCWKKDPD 433

  Fly  2470 ERPSFRRCYNTLHAISTD-LRRTQMASATADTVVSCSRPEFKVRFDGQPL 2518
            .|.:.     .||:.:.. |...::....|.|:.:.|.|...:.....|:
 Worm   434 MRQTM-----VLHSSALQLLYENKLPLLFAQTIQATSLPPGTIAQSSTPI 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020	22/122 (18%)
		PTKc_c-ros	2213..2483	CDD:270640	93/276 (34%)
T21G5.1	NP_001355382.1	SH2_Fps_family	72..165	CDD:198224	24/131 (18%)
		STYKc	189..438	CDD:214568	93/271 (34%)