Protein Alignment sev and csk-1

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001293162.1
• Gene: csk-1 / 266817
• WormBaseID: WBGene00000812
• Length: 624
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 134/548 - (24%)
• Similarity: 210/548 - (38%)
• Gaps: 154/548 - (28%)

  Fly  1964 CRLLLGYAATPGA-PLYHGTAEVYETLGDAPSQP----------------GKPQLEHIAEEV--F 2009
            |.:..|.|:|..: ..:|.||        |..||                |||....:..|.  |
 Worm   210 CDVAPGAASTTSSTSSHHSTA--------ANHQPWFHSMISRENTEKLLRGKPDGTFLVRESTNF 266

  Fly  2010 RVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNT 2074
            ...:|........:..|.:|                :.|||   ||...:|..        |.|.
 Worm   267 PGDFTLCMSFHGKVEHYRIE----------------QTSGG---QLTCDKEEY--------FSNL 304

  Fly  2075 TELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSS 2139
            |:|                     :.|    |..:::.:....|:|         ||...|..||
 Worm   305 TQL---------------------VSH----YKRDADGLCHRLVTP---------IICETATFSS 335

  Fly  2140 CVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQI 2204
                                    :..|.:.:.||:..:.:....|:.....:.:|.|:.
 Worm   336 ------------------------NGSSSFGSSSTVDLEDRTSVFRHAGLVISSNDIDVG----- 371

  Fly  2205 NWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIK-SLRKGASEFAELLQEAQLMSNFKHEN 2268
                    ..:|.|.||:|..|..|.      ::||:| |.|.|......||.||:.|....|.|
 Worm   372 --------DTIGHGEFGDVRLGTYKN------RKVALKVSKRHGNGMLDSLLDEAKFMVGLSHPN 422

  Fly  2269 IVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSY 2333
            :|.|||:..|..::.:|.|:|..|:|:..||:         :....|...:|:...:|:..|..|
 Worm   423 LVTLVGVVLDDVNVYMITEYMANGNLIDLLRS---------RGRHALERRQLMMFAMDICQGMCY 478

  Fly  2334 LEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPES 2398
            ||....||||||.||.|:       |.....|:.|||||:......:  ....|..|::|.:||:
 Worm   479 LESKQIVHRDLAARNVLL-------DDDLVAKVSDFGLAKKANSQSH--DSASGKFPIKWTAPEA 534

  Fly  2399 LVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLC 2463
            |....|||:||||:||:|.|||.:.|:.||......:|:.::::|.|::.|..|..:::.::...
 Worm   535 LRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNET 599

  Fly  2464 WRTDPWERPSFRRCYNTLHAISTDLRRT 2491
            |.....:||||.:....|    |.:|.|
 Worm   600 WALSAQDRPSFGQVLQRL----TTIRNT 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020	22/135 (16%)
		PTKc_c-ros	2213..2483	CDD:270640	88/270 (33%)
csk-1	NP_001293162.1	SH2_csk_like	232..330	CDD:198190	26/158 (16%)
		PTKc_Csk_like	362..620	CDD:270635	91/298 (31%)