DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and Alk

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_001162572.1 Gene:Alk / 266802 RGDID:628622 Length:1617 Species:Rattus norvegicus


Alignment Length:1486 Identity:346/1486 - (23%)
Similarity:526/1486 - (35%) Gaps:509/1486 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1458 PGSAP-----AKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERV 1517
            |.|.|     ..|:..|.:..:||||::            .|....:|..||      :|.....
  Rat    32 PASGPPLQPREPLSYSRLQRKSLAVDFV------------VPSLFRVYARDL------LLPQPPS 78

  Fly  1518 WSTP-------RGRLLKD----LVALPQAQSLIWLE-YEQGSPRNGSLRGRNLTDGSELEWATVQ 1570
            .|.|       ||.|..|    |..|..:..:.|.| ....||.......|.|..||      |:
  Rat    79 PSEPGAGGLEARGSLALDCDPLLRLLGPSPGISWAEGASSPSPEAAPTLSRVLKGGS------VR 137

  Fly  1571 PLIRLHAGSLEPGSETL-------------------NL--------VDNQGKLCV--------YD 1600
            .|.|.....||.|.||:                   ||        :..:|:|.:        .:
  Rat   138 KLRRAKQLVLELGEETILEGCIGPPEEAAAVGILQFNLSELFSWWILHGEGRLRIRLMPEKKASE 202

  Fly  1601 VARQLCTASALRA-QLNLL------GEDSIAGQLAQDS---GYLYAVKNWSIR-----AYGRRRQ 1650
            |.|:...::|:|| |..||      |..|:.......|   .:|:.: .|:::     ...|.|.
  Rat   203 VGREGRLSTAIRASQPRLLFQIFGTGHSSLESPSEMPSPPGNFLWNL-TWTMKDSFPFLSHRSRY 266

  Fly  1651 QLE----YTVELE---PEEVRLLQAHNYQAYPPK-----NCLLLPSS--------GGSLLKATDC 1695
            .||    :..|||   |......|:.:::..|.:     |.|..|.:        |..||..|..
  Rat   267 GLECSFDFPCELEYSPPLHTHGNQSWSWRRVPSEEASRMNLLDGPEAEHLKEMPRGSFLLLNTSA 331

  Fly  1696 EEQRCLLHLPMITASEDCPLPI-------PGVRYQLNLTLAKEPGSE------EHDHGMEPLG-- 1745
            :.:..:|...|.::||.|.|.:       |..||...|....|.|.|      ...||...|.  
  Rat   332 DSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPTPGKHGWTVLHGR 396

  Fly  1746 ------------QWLLGAGESLNLTDLL-------------------PFTRYR------------ 1767
                        :::.....||:..|..                   .||.:.            
  Rat   397 VGRPENPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDF 461

  Fly  1768 -------------VSGILSSFY----------------------QKKLALPT---------LVLA 1788
                         .|.:.:.||                      |.|....|         |:|:
  Rat   462 HQNCAQGEDEGQLCSKLPAGFYCNFEDGFCGWTQSPLSPRVPRWQVKTLKDTHSQGHQGHALLLS 526

  Fly  1789 PLE-------LLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQ 1846
            ..:       .:|::..|:|.::      ||.||.:|||....|:..   .:|...:...|:. |
  Rat   527 TTDDPTSESATVTSATFPAPMKS------SPCELRMSWLIRGVLKGN---VSLVLVENKTGKE-Q 581

  Fly  1847 DRREWEAHERRLETAGTHRLTGIKPGSGYSL---------------WVQ--------AHATPTKS 1888
            .|..|.                :....|.||               |:|        :.||....
  Rat   582 SRTVWH----------------VATNEGLSLWQWTVLSLLDVTDRFWLQIVTWWGPGSRATVAFD 630

  Fly  1889 NSSERL---------HVRSFAELPELQ-LLELGPYSLSLTWA--------------------GTP 1923
            |.|..|         ...|...:|:.: |.|..|......||                    |..
  Rat   631 NISISLDCYLTISGEEKMSLNAVPKSRNLFEKNPNKEPKPWANISGPTPIFDPTVHWLFTTCGAS 695

  Fly  1924 DPLGSLQLECRSSAEQLRRNVAGNHTKMVV---EPLQ-------PRT-RYQCRLLLGYAATPG-- 1975
            .|.|..|.:|.::.:       .::..:||   .||:       |.| .|.   :.||.|..|  
  Rat   696 GPHGPTQAQCNNAYQ-------NSNLSVVVGSEGPLRGIQIWKVPATDTYS---ISGYGAAGGKG 750

  Fly  1976 ----APLYHGTA-------EVYETLGDAPSQPGKP------QL--------EHIAEEVFRVT--- 2012
                ....||.:       |..:||.....|.|:.      ||        .::.||..||.   
  Rat   751 GKNTMMRSHGVSVLGIFNLEKDDTLYILVGQQGEDACPRANQLIQKVCVGENNVIEEEIRVNRSV 815

  Fly  2013 --WTAARG------------NGAPIAL-----------------YNLEALQARSDIRRRRRRRRR 2046
              |....|            :|.|:.|                 ::.|.|:..|.:.........
  Rat   816 HEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTETFHPERLENNSSVLGLNGNSGA 880

  Fly  2047 NSGG----SLEQLPWA------------------------------------------------- 2058
            ..||    ....|.||                                                 
  Rat   881 AGGGGGWNDNTSLLWAGKSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGN 945

  Fly  2059 ----EEPVVVEDQWLDFCN------TTELS------------------CIVKSLH----SSRLLL 2091
                .:|.:..:..:.|.:      |..|.                  |.|...|    |.:::.
  Rat   946 AASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVIC 1010

  Fly  2092 FRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLR 2156
            |      .:||.....:....:..|...|....||:|:::. :|:|::.|||...:..|.:|:.:
  Rat  1011 F------CDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVT-SALVAALVLAFSGIMIVYRRKHQ 1068

  Fly  2157 AKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAF---STTLSDADIALLPQINWSQLKLLRFLGSG 2218
            ..:.:|....|....||.|:| ..:|...|..:   ..|.|.:|:..:|:.|   :.|:|.||.|
  Rat  1069 ELQAMQMELQSPEYKLSKLRT-STIMTDYNPNYCFAGKTSSISDLKEVPRKN---ITLIRGLGHG 1129

  Fly  2219 AFGEVYEGQLK-TEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTE 2280
            |||||||||:. ..:...|.:||:|:|.:..||..||  |.||.::|.|.|:|||..:|:.....
  Rat  1130 AFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQAL 1194

  Fly  2281 SISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLA 2345
            ...:::|.|..|||.|:||..|   .:..|||: |::.:||.:..|:|.||.|||:.||:|||:|
  Rat  1195 PRFILLELMAGGDLKSFLRETR---PRPNQPTS-LAMLDLLHVARDIACGCQYLEENHFIHRDIA 1255

  Fly  2346 CRNCLVT-ESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSD 2409
            .||||:| ...|     |..||||||:|||||::.||||.|..:|||:||.||:.::|:||:::|
  Rat  1256 ARNCLLTCPGAG-----RIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTD 1315

  Fly  2410 VWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSF 2474
            .|:||||.|||.:||..||.:::|.|||..|..|||:..|..|...:|.::..||:..|.:||:|
  Rat  1316 TWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF 1380

  Fly  2475 RRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPED 2530
                      :..|.|.:..:...|.:.:....|:     |..:||..:...||:|
  Rat  1381 ----------AIILERIEYCTQDPDVINTALPIEY-----GPVVEEEEKVPMRPKD 1421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 25/129 (19%)
FN3 1993..2111 CDD:238020 32/250 (13%)
Pkinase_Tyr 2209..2481 CDD:285015 124/275 (45%)
PTKc_c-ros 2213..2483 CDD:270640 123/273 (45%)
AlkNP_001162572.1 MAM 270..431 CDD:279023 32/160 (20%)
MAM 270..428 CDD:99706 32/157 (20%)
MAM 484..640 CDD:279023 31/181 (17%)
MAM 484..635 CDD:99706 30/176 (17%)
FXa_inhibition 991..1025 CDD:291342 7/39 (18%)
PTKc_ALK_LTK 1113..1389 CDD:270632 128/297 (43%)
Pkinase_Tyr 1120..1387 CDD:285015 125/285 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D27151at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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