DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and Igf1r

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_008757722.1 Gene:Igf1r / 25718 RGDID:2869 Length:1372 Species:Rattus norvegicus


Alignment Length:1132 Identity:299/1132 - (26%)
Similarity:441/1132 - (38%) Gaps:277/1132 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1527 KDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVD 1591
            |.:.::..||.|......:|:......||.|:  .||||  ....||.:..|.::          
  Rat   340 KTIDSVTSAQMLQGCTILKGNLLINIRRGNNI--ASELE--NFMGLIEVVTGYVK---------- 390

  Fly  1592 NQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTV 1656
                   ...:..|.:.|.|:....:|||:.:.|..:     .|.:.|          |.|:...
  Rat   391 -------IRHSHALVSLSFLKNLRLILGEEQLEGNYS-----FYVLDN----------QNLQQLW 433

  Fly  1657 ELEPEEVRLLQAHNYQAYPPKNCL--------LLPSSG----GSLLKATDCEEQRCLLHLPMITA 1709
            :.....:.:.....|.|:.||.|:        :..:.|    |.:....:.|...|...:...|:
  Rat   434 DWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTS 498

  Fly  1710 SEDCPLPI---------PGVRYQLNLTL----AKEPGSEEHDHGMEPLGQWLLGAGESLNLTD-- 1759
            :......|         |..|..::.|:    |......|:| |.:..|      ..|.|:.|  
  Rat   499 TTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYD-GQDACG------SNSWNMVDVD 556

  Fly  1760 ---------------LLPFTRYRVSGILSSFYQKKLALPTLVL------APLELL---TASATPS 1800
                           |.|:|:|.|       |.|.:.| |:|.      |..|:|   |.::.||
  Rat   557 LPPNKEGEPGILLHGLKPWTQYAV-------YVKAVTL-TMVENDHIRGAKSEILYIRTNASVPS 613

  Fly  1801 PPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQ-QELDG-----------ENVQDRREWEA 1853
            .|.:......|..:|.|.|.||........||.:.|| |..||           :.:..|:..:.
  Rat   614 IPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKADKIPIRKYADG 678

  Fly  1854 H---ERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSER------LHVRSFAELPE----- 1904
            .   |...|...|....|.|.........:|.....|..:..|      ||...|...||     
  Rat   679 TIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRD 743

  Fly  1905 -LQLLE--LGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRL 1966
             ||:..  :...|.:.|.|.|.:.....:.|......:.|   ..|..:.|:..|:|.|.|:..:
  Rat   744 VLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESR---VDNKERTVISNLRPFTLYRIDI 805

  Fly  1967 LLGYAATPGAPLYHGTAEVYETLGDAPSQ---------------PGKPQLEHIAEEVFRVTWTAA 2016
                         |......|.||.:.|.               ||....|...|....:.|...
  Rat   806 -------------HSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEP 857

  Fly  2017 RGNGAPIALYNLEALQARSDIRR--RRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSC 2079
            ......|.:|.::......|.|.  .|:..|:..|..|.:|                 |....:.
  Rat   858 ENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRL-----------------NPGNYTA 905

  Fly  2080 IVKSLHSSRLLLFRVRARSLEHGWGPYSE------ESERVAEPFVSPEKRGSLVLAI-IAPAAIV 2137
                         |::|.||. |.|.:::      .::...|.|:      .|::|: :|...||
  Rat   906 -------------RIQATSLS-GNGSWTDPVFFYVPAKTTYENFM------HLIIALPVAILLIV 950

  Fly  2138 SSCVLAL-VLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALL 2201
            ...|:.| |..||....||....|.....|..:                        |.||: .:
  Rat   951 GGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYF------------------------SAADV-YV 990

  Fly  2202 PQINW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQ-RVAIKSLRKGAS--EFAELLQEAQ 2259
            |. .|    .::.:.|.||.|:||.||||..|....:||: |||||::.:.||  |..|.|.||.
  Rat   991 PD-EWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1054

  Fly  2260 LMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMC 2324
            :|..|...::|.|:|:....:...:|||.|..|||.||||:.|....|........|||:::.|.
  Rat  1055 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNLVLIPPSLSKMIQMA 1119

  Fly  2325 IDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLL 2389
            .::|:|.:||....|||||||.|||:|.|..       ||||||||:.||||::|||||.|:|||
  Rat  1120 GEIADGMAYLNANKFVHRDLAARNCMVAEDF-------TVKIGDFGMTRDIYETDYYRKGGKGLL 1177

  Fly  2390 PVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTE 2454
            ||||||||||.||:|||.||||:|||:.|||.||.:|||...:|.:||..|.|||.|.:|..|.:
  Rat  1178 PVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPD 1242

  Fly  2455 KLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEF-KVRFDGQPL 2518
            .|:.|:.:||:.:|..||||.....::        :.:|            .|.| :|.|     
  Rat  1243 MLFELMRMCWQYNPKMRPSFLEIIGSI--------KDEM------------EPSFQEVSF----- 1282

  Fly  2519 EEHREHNERPEDENLTLREVPLKDKQL 2545
             .:.|.|:.||.|.|.: |:.|:.:.:
  Rat  1283 -YYSEENKPPEPEELEM-ELELEPENM 1307

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 27/118 (23%)
FN3 1993..2111 CDD:238020 22/140 (16%)
Pkinase_Tyr 2209..2481 CDD:285015 133/274 (49%)
PTKc_c-ros 2213..2483 CDD:270640 133/272 (49%)
Igf1rXP_008757722.1 Recep_L_domain 51..161 CDD:279382
Furin-like 175..330 CDD:279142
TNFRSF 207..336 CDD:304602
FU 230..277 CDD:238021
Recep_L_domain 353..467 CDD:279382 27/149 (18%)
FN3 494..607 CDD:238020 26/127 (20%)
FN3 612..>656 CDD:238020 14/43 (33%)
FN3 837..926 CDD:238020 21/119 (18%)
PTKc_InsR_like 994..1271 CDD:173625 134/291 (46%)
Pkinase_Tyr 1001..1266 CDD:285015 133/271 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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