DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and Ros1

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_038954373.1 Gene:Ros1 / 25346 RGDID:3591 Length:2339 Species:Rattus norvegicus


Alignment Length:2528 Identity:674/2528 - (26%)
Similarity:1034/2528 - (40%) Gaps:518/2528 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 QMRLLRPKLDSDVVEKVAIWHKHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGV 207
            ::|.|.||..:.|| ...:|        .|:.:|..:||...|.:.:.....|     |..::.:
  Rat     3 RIRWLTPKPATFVV-LGCVW--------ISVAQGTILSSCLTSCVTNLGRQLD-----SGTRYNL 53

  Fly   208 DERMVLERVTRDCVQRCIVEEDLFLDEF--GIQCEKADNGEKCYKTRCTKGCAQWYRALKELESC 270
            .|.         |:|.|         :|  .|..||           |...|...|..:.|.|||
  Rat    54 SEA---------CIQGC---------QFWNSIDQEK-----------CALKCNDTYVTICERESC 89

  Fly   271 QEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADG-QSTPLTIRWA 334
            :..|.:.:         |:.|              ..:::.|  :|..||.|.. .|..:|:||.
  Rat    90 EVGCSNAE---------GSYE--------------EEVLDNT--ELPTAPFASSIGSNGVTLRWN 129

  Fly   335 MHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVCEILEAL 399
               |.: ::...:.||:::....|..         |..||.|...:              ::|.|
  Rat   130 ---PAN-ISGVKYIIQWKYAQLPGSW---------AYTETVSKLSY--------------MVEPL 167

  Fly   400 IPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSHLAVHWHPGRFT 464
            .|:|:|.||....|.....  ||||.:|:|:|.|.|.|.:||.|.::.......:.|.|.|..|.
  Rat   168 HPFTEYIFRVVWIFTAQLH--LYSPPSPSYRTHPYGVPETAPFITNIESSSPDTVEVSWAPPYFP 230

  Fly   465 NGPIEGYRLRLSSSEGNATSEQLVPAG--RGSYIFSQLQAGTNYTLALSMINKQGEGPVAKGFVQ 527
            .|||.||.|||.|      ..|.:.:|  |.|:.|......|.|..:::.:|:.||||.|:..:.
  Rat   231 GGPILGYNLRLIS------KTQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESMIT 289

  Fly   528 THSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKR-EQQLWLLNVH 591
            |.|     ||....|..|.:.|:.    ||.   :.|:.|...|  |...||.. ...:..::|:
  Rat   290 TPS-----PAVQEEEQWLFLSRKT----SLR---KRSLKYLVDE--AHCLWSDAIRHNITGISVN 340

  Fly   592 GELRSLKFESGQMV--------SPAQQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAMESPERNQ 648
            .:...:.|..|.::        |....|::    ...|..:...:|.|||:.|:||.|::     
  Rat   341 TQQEVVYFSEGTIIWMKGAANMSDVSDLRI----FYRGSALVSSISVDWLYQRMYFIMDN----- 396

  Fly   649 SSFQIISTDLLGESTQKVGESFDLPVEQ-LEVDALNGWIFWRNEESLWRQDLHGRMIH--RLLRI 710
               ::...||...|..:....|.:...| :.||:.||::|:...:.::|..|....:.  :.:||
  Rat   397 ---RVHVCDLKHCSNLEEITPFSIVAPQKVVVDSYNGYVFYLLRDGIYRVHLPLPSVRDTKAVRI 458

  Fly   711 RQPGW---FLVQPQHFIIHLMLPQEGKFLEISYDG-GFKHPLPLPPPSNGAGNGPASSHWQSFAL 771
            .:.|.   |.|:||...|.........|:....|| .|...||..|.::          .:|||.
  Rat   459 VESGTLKDFAVKPQSKRIIYFNGTMQVFMSTFLDGSAFHRVLPWVPLAD----------VKSFAC 513

  Fly   772 LGRSLLLPDSGQLILVEQQ--------GQAASPSASWPLKNLPDCWAVILLVPESQPLTSAGGKP 828
            .....|:.| |:.|..:..        |...|....:...||    .:.....:|.||.   |.|
  Rat   514 ENNDFLITD-GKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNL----VIFGSSVQSYPLP---GHP 570

  Fly   829 HSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFS----IRNIRGPIFGLQ 889
            ..:..|.|::.|.|.||.|......|..|.::|:||::   |:||....    ..||...:..:.
  Rat   571 QEVSVLFGSREALIQWKPPILAIGASPSAWQNWTYEVK---VSSQDILETTQVFLNISRTVLNVP 632

  Fly   890 RLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLRWASRQGSVIHTNELGEGLEVQQEQ 954
            :||....|.:.|||.:..| ||.|:||....|                ::...|....:.|:::.
  Rat   633 KLQSSTKYMVSVRASSPKG-PGPWSEPSVGTT----------------LVPATEPPFIMAVKEDG 680

  Fly   955 LERLP----GPMTMVNESVG------------YYVTGDGLLHCINLVHSQWGCPISEPLQHVGSV 1003
            |...|    ||...::..||            ||....|.::    |....|..|||. .|:.|:
  Rat   681 LWSKPLSSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVY----VRPLNGMDISEN-YHISSI 740

  Fly  1004 ------TYDWRGGRVYWTDLARNCVV-RMDPWSGSRELLPVFE--ANFLALDPRQGHLYYAT--- 1056
                  .::|.|..:||.  .:..|: |....:|..:::...:  .|.:|:||..|:||:.|   
  Rat   741 AGACALAFEWLGHFLYWA--GKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDPVGGYLYWTTLYS 803

  Fly  1057 --SSQLSRHGSTPDEAVTYYRVNGLEG-SIASFVLDTQQDQLFWLVKGSGALRLYRAPLTAGGDS 1118
              |::|:...|...:|..:     |.| .:.:..||.....|:|||:.:..:.||.|.|.....:
  Rat   804 VESTRLNGESSLVLQAQPW-----LSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGA 863

  Fly  1119 LQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQL 1183
            ...|.:......:......|:...|.|.|:  :|.|....:.......:.:..|.:.:..:.:| 
  Rat   864 DATITEFAAWSTSEISQNALMYYSGRLFWI--NGFRIITAQEIGQRTSVSVSEPGKFNQFTIIQ- 925

  Fly  1184 LDPQPLPPRDEGVIPMTVLPDSVRLD----DGHWDDFHVRWQ--PSTSGGNHSVSYRLLLEFGQR 1242
            ...:|||......  .||:||||:..    :||...|.:.|.  |:...|  .|.|.  :||...
  Rat   926 TSLKPLPGNFSST--PTVIPDSVQESSFRIEGHTSSFRILWNEPPAVDWG--IVFYS--VEFSAH 984

  Fly  1243 LQTLDL---STPFARLTQL-PQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFVE 1303
            .:.|.:   |.|...:..| |.|...|  |:||.|.|..|..|.:....|...||.|...|:|:.
  Rat   985 SKFLAIEQQSLPVFTVEGLEPYALFNL--SVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFIL 1047

  Fly  1304 RLATALQEANVSAVLRWDAP--EQGQEAPMQALEYHISCWVGSELHEE----LRLNQSALEARVE 1362
            .|....::..|....||:.|  |.|.....: :.||||...|:....|    :.:....:..::|
  Rat  1048 SLGRYTRKNEVVVEFRWNKPKHENGVLTKSE-IFYHISKQSGTNKSTEDWVSVSVTPPVMSFQLE 1111

  Fly  1363 HLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVH 1427
            .:.|.....|||  ||..:......:...:....|::..|.::......|..||:|   :.::|.
  Rat  1112 AMSPGYIVSFQV--RVFTSKGPGPFSDIVMSKTSEIKPCPYLISLLGNKIEFLDMD---QNQVVW 1171

  Fly  1428 TASPVEHLVGIEG----EQRLLWVNEHVELLTHVPGSAPAKLAR--MRAEVLALAVDWIQRIVYW 1486
            |.| :|..|...|    ::...:.......|.::...:.:||.:  :.:::..:|||||.|.:|:
  Rat  1172 TFS-LEGAVSTVGYTADDEMGYFAQGDALFLLNLHNHSSSKLFQDVLASDIAVIAVDWIARHLYF 1235

  Fly  1487 ---AELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRG-RLLKDLVAL------PQAQSLIWL 1541
               |..|.|.     |:.:||   |.|:       .:||. ::.|...|:      |....|.|.
  Rat  1236 ALKASQDGTQ-----IFDVDL---EHKV-------KSPREVKICKSHTAIISFSMYPLLSRLYWT 1285

  Fly  1542 E-----YEQG-------------SPRNGSLRGR-----NLTDGSELEWATVQPLIRLHAGSLEPG 1583
            |     |:..             .|:..:..||     |:|: |||..|       :...:.:|.
  Rat  1286 EVSDLGYQMFYCNISSHTLHHVLQPKASNQHGRRQCSCNVTE-SELSGA-------MTVDTSDPD 1342

  Fly  1584 --------SETLNLVDNQGKLCVYDVARQLCTASALR-AQLNLLGEDSIAGQLAQDSGYLYAVKN 1639
                    .:.:..:|.:|..| :.|.....|.:..| ..|.:.||........:|...:|..|.
  Rat  1343 RPWIYFTKQQEIWAMDLEGCQC-WKVIMVPATPAGKRIISLTVDGEFIYWITTMKDDTEIYQAKK 1406

  Fly  1640 WS------IRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSS--GGSLLKATDCE 1696
            .|      ::| .|.:..|.|:..|:|             :|.|..|.:.|:  ..|:|.||:..
  Rat  1407 GSGAILSQVKA-PRSKHILAYSSALQP-------------FPDKAYLSVASNMVEASILNATNTS 1457

  Fly  1697 EQRCLLHLPMITASEDC-PLPIPGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESL-NLTD 1759
               .:|.||.:..:... .:..|...|.:....|....|.:..|.|       |.:.|:: .:..
  Rat  1458 ---LILKLPPVKTNLTWHGITTPTSTYLVYYMEANRANSSDRKHNM-------LESQENVARIEG 1512

  Fly  1760 LLPFTRYRVSGILSSFYQKKLALPTLVLAPLELL---------TASATPSPPRNFSVRVLSPREL 1815
            |.||:.|.:...:.::|..          |||.|         |.|..|....:.:..|||...|
  Rat  1513 LQPFSTYVIQIAVKNYYSD----------PLEHLSLGKEIQGKTKSGVPGAVCHINATVLSDTSL 1567

  Fly  1816 EVSWL-------PPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGS 1873
            .|.|.       |.|.:|.:.|...|....|      ...|:.|....||....| :|:|   |.
  Rat  1568 LVFWTESHKPNGPKELVRYQLVMSYLAPIPE------TPLRQDEFPSARLSLLVT-KLSG---GQ 1622

  Fly  1874 GYSLWVQA-HATPTKSNSSERLHVRSF-------AELPELQLLEL---GPYSLSLT--WAGTPDP 1925
            .|.|.:.| |:.......|..:.|..|       |.:||...|.|   .|.:.:||  |......
  Rat  1623 QYVLKILACHSEEMWCTESHPVSVNMFDTPEKPSALVPENTSLLLDWKAPSNANLTRFWFELQKW 1687

  Fly  1926 LGSLQLECRSSAEQ---LRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYE 1987
            ..|.....::|..|   ...|:|.         |||.|.|..|:::.|.....:   ....|.::
  Rat  1688 KYSEFYHVKASCSQGPVYVCNIAN---------LQPYTPYNIRVVVVYTTGENS---SSIPESFK 1740

  Fly  1988 TLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSL 2052
            |....||:||.|:|...::.  .:.|..|..||..:..|.||.             |:..|..|.
  Rat  1741 TKAGVPSKPGIPKLLEGSKN--SIQWEKAEDNGNRLMYYTLEV-------------RKSISNDSR 1790

  Fly  2053 EQ-LPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESE---RV 2113
            :| |.|...          |..:....|..:|.:......||..| |...|:|.|||.||   .|
  Rat  1791 DQSLRWTAV----------FNGSCSSICTWRSKNLKGTFQFRAVA-SNAIGFGEYSEISEDITLV 1844

  Fly  2114 AEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTL-QT 2177
            .:.|...|.  |.:|.||....:|::..|..|..|.::..  :|.|          ..||.| ..
  Rat  1845 EDGFWITET--SFILTIIVGIFLVATVPLTFVWHRSLKNH--KATK----------EGLSVLNDN 1895

  Fly  2178 QQQLMAVRNRAFSTTLSDA-----------DIALLPQINWSQLKLLRFLGSGAFGEVYEG---QL 2228
            .|:|..:|..|....|::|           :|..||.....:|.|...||||||||||||   .:
  Rat  1896 DQELAELRGLAAGVGLANACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGEVYEGTAVDI 1960

  Fly  2229 KTEDSEEPQRVAIKSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEA 2291
            ....|.| .:||:|:|:||::  |..|.|:||.|||.|.|.||:..:|:|..:|...:|:|.||.
  Rat  1961 LGRGSGE-IKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLSEPQYIILELMEG 2024

  Fly  2292 GDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTG 2356
            ||||||||.||.|:...|.    |:|::|:.:|:|::.||.|||.|||:|||||.|||||  |..
  Rat  2025 GDLLSYLRKARGTTLSGPL----LTLADLVELCVDISKGCVYLEQMHFIHRDLAARNCLV--SVK 2083

  Fly  2357 STDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEIL 2421
            .....|.||||||||||:|||.|||||.||||||||||:||:|:||:||:|||||:||:|.||||
  Rat  2084 DYTSPRVVKIGDFGLAREIYKHDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEIL 2148

  Fly  2422 TLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYN 2479
            |||.|||.|.:|.:||.:|:.||||:.|..|.:.|::|:..||..:|.:||:|   ||
  Rat  2149 TLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMFRCWAQEPDQRPTF---YN 2203

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470 26/82 (32%)
FN3 826..921 CDD:238020 31/98 (32%)
LY 993..1026 CDD:214531 11/39 (28%)
FN3 1292..1374 CDD:214495 21/87 (24%)
FN3 1799..1897 CDD:238020 26/105 (25%)
FN3 1993..2111 CDD:238020 31/118 (26%)
Pkinase_Tyr 2209..2481 CDD:285015 152/276 (55%)
PTKc_c-ros 2213..2483 CDD:270640 150/272 (55%)
Ros1XP_038954373.1 FN3 111..178 CDD:214495 22/93 (24%)
FN3 211..290 CDD:238020 26/84 (31%)
FN3 567..663 CDD:238020 31/102 (30%)
FN3 1036..1142 CDD:238020 25/108 (23%)
FN3 1449..1527 CDD:214495 19/87 (22%)
FN3 1551..1630 CDD:238020 23/88 (26%)
FN3 1650..1741 CDD:238020 22/102 (22%)
FN3 1746..1839 CDD:238020 31/118 (26%)
PTKc_c-ros 1948..2209 CDD:270640 146/266 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351009
Domainoid 1 1.000 291 1.000 Domainoid score I1481
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2207
Inparanoid 1 1.050 494 1.000 Inparanoid score I1341
OMA 1 1.010 - - QHG47409
OrthoDB 1 1.010 - - D203310at2759
OrthoFinder 1 1.000 - - FOG0006628
OrthoInspector 1 1.000 - - oto97359
orthoMCL 1 0.900 - - OOG6_108587
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5629
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.810

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