Protein Alignment sev and FYN

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_002028.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 103/288 - (35%)
• Similarity: 156/288 - (54%)
• Gaps: 26/288 - (9%)

  Fly  2187 RAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEF 2251
            |....::...|:..:|:   ..|:|::.||:|.||||:.|.....     .:||||:|:.|....
Human   252 RLTDLSVKTKDVWEIPR---ESLQLIKRLGNGQFGEVWMGTWNGN-----TKVAIKTLKPGTMSP 308

  Fly  2252 AELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLS 2316
            ...|:|||:|...||:.:|.|..:..: |.|.::.|:|..|.||.:|:.....:         |.
Human   309 ESFLEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRA---------LK 363

  Fly  2317 LSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY 2381
            |..|:.|...||.|.:|:|.|:::||||...|.||....       ..||.||||||.|..::|.
Human   364 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGL-------ICKIADFGLARLIEDNEYT 421

  Fly  2382 RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRL 2446
            .::| ...|::|.:||:.:.|.||.:||||:||:|..|::|.|:.||...||.|||..|:.|.|:
Human   422 ARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRM 485

  Fly  2447 QQPPMCTEKLYSLLLLCWRTDPWERPSF 2474
            ..|..|...|:.|::.||:.||.|||:|
Human   486 PCPQDCPISLHELMIHCWKKDPEERPTF 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020
		PTKc_c-ros	2213..2483	CDD:270640	98/262 (37%)
FYN	NP_002028.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281
		PTKc_Fyn	261..534	CDD:270655	102/279 (37%)