DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and Insr

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_058767.2 Gene:Insr / 24954 RGDID:2917 Length:1384 Species:Rattus norvegicus


Alignment Length:1175 Identity:285/1175 - (24%)
Similarity:439/1175 - (37%) Gaps:370/1175 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1583 GSETLNLVDNQGKLCVYDVARQL--CTASALRAQLNLLGEDSIAGQLAQD-------SGYL---- 1634
            |.:|::.|.:         |::|  ||.......:|:.|.:::|.:|..:       ||:|    
  Rat   344 GEKTIDSVTS---------AQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRR 399

  Fly  1635 -YAVKNWS-------IRA----------YGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCL- 1680
             ||:.:.|       ||.          |....|.|....:.....:.:.|...:..|.||.|| 
  Rat   400 SYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFFHYNPKLCLS 464

  Fly  1681 --------------------LLPSSGGSLLKATDCEEQRCLLHLPMITASEDC------PLPIPG 1719
                                .|.::|..    ..||.:  ||....|..|.|.      |...|.
  Rat   465 EIHKMEEVSGTKGRQERNDIALKTNGDQ----ASCENE--LLKFSFIRTSFDKILLRWEPYWPPD 523

  Fly  1720 VR-------------YQLNLT----------------------LAKEPGSEEHDH------GMEP 1743
            .|             || |:|                      .:.:|.|:...|      |::|
  Rat   524 FRDLLGFMLFYKEAPYQ-NVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKP 587

  Fly  1744 LGQWLLGAGESLNLTDLLPFTRYRVSGILSS--FYQKKLALPTLVLAPLELLTASATPSPPRNFS 1806
            ..|:.:.....:..:|     ..|..|..|.  :.|.....|::.|.|:.:..:|:         
  Rat   588 WTQYAIFVKTLVTFSD-----ERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSS--------- 638

  Fly  1807 VRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKP 1871
                   ::.:.|.||........:|.::|:::     .:|...:|.         .:.|.|:|.
  Rat   639 -------QIILKWKPPSDPNGNITHYLVYWERQ-----AEDSELFEL---------DYCLKGLKL 682

  Fly  1872 GSGYSLWVQAHATPTKSNSSERLHVRSFAE---------------LPELQ--------------- 1906
            .|  ..|    :.|.:|:.|::.:...:.:               |.||:               
  Rat   683 PS--RTW----SPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNV 741

  Fly  1907 ------------------------LLELGPYSLSLTWAGTPD-PLGSLQLECRSSAEQLRRNVAG 1946
                                    |.|:|  :::.|....|| |..|..:...|..|........
  Rat   742 VFVPRKTSSGNGAEDTRPSRKRRSLEEVG--NVTATTPTLPDFPNISSTIAPTSHEEHRPFEKVV 804

  Fly  1947 NHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVF-- 2009
            |...:|:..|:..|.|:..|   .|....:|....:...|.:....|.......:..:..|:|  
  Rat   805 NKESLVISGLRHFTGYRIEL---QACNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFEN 866

  Fly  2010 ---RVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDF 2071
               .:.|...:.....|.||         ::..||                      ..|:.|..
  Rat   867 NVVHLMWQEPKEPNGLIVLY---------EVSYRR----------------------YGDEELHL 900

  Fly  2072 CNT-----TELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEES-----------ERVAEPFVSP 2120
            |.:     .|..|.::.|......: ||||.||. |.|.::|.:           ..:|:..:.|
  Rat   901 CVSRKHFALERGCRLRGLSPGNYSV-RVRATSLA-GNGSWTEPTYFYVTDYLDVPSNIAKIIIGP 963

  Fly  2121 EKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVR 2185
                  ::.:...:.::.|..|.|      :||        |...|           ...|.|..
  Rat   964 ------LIFVFLFSVVIGSIYLFL------RKR--------QPDGP-----------MGPLYASS 997

  Fly  2186 NRAFSTTLSDADI----ALLPQINW----SQLKLLRFLGSGAFGEVYEGQLK-TEDSEEPQRVAI 2241
            |..:   ||.:|:    ..:|. .|    .::.|||.||.|:||.||||..| ....|...|||:
  Rat   998 NPEY---LSASDVFPSSVYVPD-EWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAV 1058

  Fly  2242 KSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARAT 2304
            |::.:.||  |..|.|.||.:|..|...::|.|:|:....:...::||.|..|||.|:||:.|..
  Rat  1059 KTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPD 1123

  Fly  2305 STQ---EPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKI 2366
            :..   .|.||    |.|::.|..::|:|.:||....|||||||.|||:|....       ||||
  Rat  1124 AENNPGRPPPT----LQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDF-------TVKI 1177

  Fly  2367 GDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAAR 2431
            ||||:.||||::|||||.|:|||||||||||||.||:||..||:|:|||:.|||.:|.:|||...
  Rat  1178 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGL 1242

  Fly  2432 NNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASA 2496
            :|.:||..|.:||.|..|..|.|:|..|:.:||:.:|..||:|....|.|   ..||        
  Rat  1243 SNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLL---KDDL-------- 1296

  Fly  2497 TADTVVSCSRPEF-KVRFDGQPLEEHREHNERPEDENL-----TLREVPL------KDKQLYANE 2549
                     .|.| :|.|      .:.|.|:.||.|.|     .:..|||      :.::....|
  Rat  1297 ---------HPSFPEVSF------FYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGCRE 1346

  Fly  2550 GVSRL 2554
            |.|.|
  Rat  1347 GGSSL 1351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 15/97 (15%)
FN3 1993..2111 CDD:238020 24/138 (17%)
Pkinase_Tyr 2209..2481 CDD:285015 128/277 (46%)
PTKc_c-ros 2213..2483 CDD:270640 127/275 (46%)
InsrNP_058767.2 Recep_L_domain 52..164 CDD:279382
Furin-like 179..337 CDD:279142
FU 234..281 CDD:238021
Recep_L_domain 359..472 CDD:279382 23/112 (21%)
FN3 624..>667 CDD:238020 9/63 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 688..710 3/21 (14%)
Insulin-binding. /evidence=ECO:0000250 735..743 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..784 6/37 (16%)
FN3 869..946 CDD:238020 21/109 (19%)
Important for interaction with IRS1, SHC1 and STAT5B 998..1001 1/2 (50%)
PTKc_InsR 1018..1305 CDD:133192 135/317 (43%)
Pkinase_Tyr 1025..1292 CDD:285015 128/277 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1362..1384
PIK3R1 binding. /evidence=ECO:0000250 1363..1366
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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