Sequence 1: | NP_511114.2 | Gene: | sev / 32039 | FlyBaseID: | FBgn0003366 | Length: | 2554 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_058767.2 | Gene: | Insr / 24954 | RGDID: | 2917 | Length: | 1384 | Species: | Rattus norvegicus |
Alignment Length: | 1175 | Identity: | 285/1175 - (24%) |
---|---|---|---|
Similarity: | 439/1175 - (37%) | Gaps: | 370/1175 - (31%) |
- Green bases have known domain annotations that are detailed below.
Fly 1583 GSETLNLVDNQGKLCVYDVARQL--CTASALRAQLNLLGEDSIAGQLAQD-------SGYL---- 1634
Fly 1635 -YAVKNWS-------IRA----------YGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCL- 1680
Fly 1681 --------------------LLPSSGGSLLKATDCEEQRCLLHLPMITASEDC------PLPIPG 1719
Fly 1720 VR-------------YQLNLT----------------------LAKEPGSEEHDH------GMEP 1743
Fly 1744 LGQWLLGAGESLNLTDLLPFTRYRVSGILSS--FYQKKLALPTLVLAPLELLTASATPSPPRNFS 1806
Fly 1807 VRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKP 1871
Fly 1872 GSGYSLWVQAHATPTKSNSSERLHVRSFAE---------------LPELQ--------------- 1906
Fly 1907 ------------------------LLELGPYSLSLTWAGTPD-PLGSLQLECRSSAEQLRRNVAG 1946
Fly 1947 NHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVF-- 2009
Fly 2010 ---RVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDF 2071
Fly 2072 CNT-----TELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEES-----------ERVAEPFVSP 2120
Fly 2121 EKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVR 2185
Fly 2186 NRAFSTTLSDADI----ALLPQINW----SQLKLLRFLGSGAFGEVYEGQLK-TEDSEEPQRVAI 2241
Fly 2242 KSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARAT 2304
Fly 2305 STQ---EPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKI 2366
Fly 2367 GDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAAR 2431
Fly 2432 NNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASA 2496
Fly 2497 TADTVVSCSRPEF-KVRFDGQPLEEHREHNERPEDENL-----TLREVPL------KDKQLYANE 2549
Fly 2550 GVSRL 2554 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
sev | NP_511114.2 | fn3 | 439..520 | CDD:278470 | |
FN3 | 826..921 | CDD:238020 | |||
LY | 993..1026 | CDD:214531 | |||
FN3 | 1292..1374 | CDD:214495 | |||
FN3 | 1799..1897 | CDD:238020 | 15/97 (15%) | ||
FN3 | 1993..2111 | CDD:238020 | 24/138 (17%) | ||
Pkinase_Tyr | 2209..2481 | CDD:285015 | 128/277 (46%) | ||
PTKc_c-ros | 2213..2483 | CDD:270640 | 127/275 (46%) | ||
Insr | NP_058767.2 | Recep_L_domain | 52..164 | CDD:279382 | |
Furin-like | 179..337 | CDD:279142 | |||
FU | 234..281 | CDD:238021 | |||
Recep_L_domain | 359..472 | CDD:279382 | 23/112 (21%) | ||
FN3 | 624..>667 | CDD:238020 | 9/63 (14%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 688..710 | 3/21 (14%) | |||
Insulin-binding. /evidence=ECO:0000250 | 735..743 | 0/7 (0%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 748..784 | 6/37 (16%) | |||
FN3 | 869..946 | CDD:238020 | 21/109 (19%) | ||
Important for interaction with IRS1, SHC1 and STAT5B | 998..1001 | 1/2 (50%) | |||
PTKc_InsR | 1018..1305 | CDD:133192 | 135/317 (43%) | ||
Pkinase_Tyr | 1025..1292 | CDD:285015 | 128/277 (46%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1362..1384 | ||||
PIK3R1 binding. /evidence=ECO:0000250 | 1363..1366 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 1 | 1.100 | - | - | O | PTHR24416 |
Phylome | 1 | 0.910 | - | - | ||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
2 | 2.010 |