DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and ros1

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_009291185.1 Gene:ros1 / 245951 ZFINID:ZDB-GENE-020506-1 Length:1443 Species:Danio rerio


Alignment Length:2272 Identity:469/2272 - (20%)
Similarity:699/2272 - (30%) Gaps:1043/2272 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   376 SSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISA 440
            |..|.. |:...:..|..|.||   |||.|.||......|.:   ..|||:|.|||.|.|.| |:
Zfish   102 SGIWAQ-AENVTESSYTVEQLE---PYTYYTFRVWAVIAETQ---ACSPASPWYQTKPFGLP-SS 158

  Fly   441 PVIEHLMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQ----LQ 501
            |.||::..:....:.|.|.|.....|||.|:.|.|:|      ::..:.|..|..:||.    ..
Zfish   159 PSIENVESISGESVEVRWTPPEKPRGPILGFNLNLTS------NKHKISAATGGNVFSNTFYPTF 217

  Fly   502 AGTNYTLALSMINKQGEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRR------AVMWQSLEPA 560
            ..|.|.::::.:|::|:|.||:..:.|       ||:        ||:.      |..|.||...
Zfish   218 HNTTYRISIAAVNEEGQGSVAEASITT-------PAQ--------VGQDGGRWVFASRWSSLRMR 267

  Fly   561 GENSMIYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESGQ--MVSPAQQL--KLDLGNISSG 621
            .|::..:.:.:.|:|   |:.|..:..:.||.....:.|..|.  .|..|..|  ..||..:.:.
Zfish   268 EEDADFFTTAQCLSD---SRIEGNITGVAVHYNSNHVYFSEGSRIWVKGAGNLTDHSDLKLLHTA 329

  Fly   622 RWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESTQKVGESFDLPVEQLEV--DALNG 684
            ......|:.|||:.|:|:|         |...|....|.:....|..:.:|..:.:.:  |..||
Zfish   330 PLEVTALTVDWLYLRIYYA---------SGGRIHYCGLDDCLSPVDTNVNLSSDAVNIIADPYNG 385

  Fly   685 WIFWRNEESLWRQDL-----HGRMIHRLLRIRQPGWFLVQ-PQHFIIHLMLPQEGKFLE-ISYDG 742
            |::......::|..|     ..:.|..::::.....|:|. |...|::  ..:..:.|. .|.||
Zfish   386 WLYMLLSTGIYRSPLPDVSSQQQEISHIIKMPSVSNFVVSFPNKRIVY--HDRSDQTLNATSLDG 448

  Fly   743 GFKHPLPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLI-----LVEQQGQAASP------ 796
            .|  |:.|....|...|               |::..|:..::     :.:|.||:..|      
Zfish   449 LF--PITLYTNVNFEAN---------------SIVYEDNFFMLTNGYAVYKQVGQSQVPTFFEFA 496

  Fly   797 -------SASWPLKNLPDCW----AVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERN 850
                   |.:....||  |:    |.:..||.         ||..|:.|.|:..|.:.|.:||..
Zfish   497 MDCDIIHSENGGFDNL--CYFSTSAQLYPVPR---------KPKDLQVLFGSDKAYVYWNKPESM 550

  Fly   851 PYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTE 915
            ...|..|.::|:|.:. ..:......|||.:......:..||....|.:.|||.:    ||..:.
Zfish   551 MGASPSAWQNWTYAIN-CTMNGLVVMSIREVTSTYATVPDLQSSQHYNVTVRACS----PGGCSR 610

  Fly   916 PLAARTWPLGPHRLRWASRQGSVIHTNE-------LGEGLEVQQ--------EQLERLPG---PM 962
            .|               |.:|:.:|..:       ..:|..::|        ||:..|.|   .|
Zfish   611 SL---------------SYEGTTLHPADEPPYIAAASDGDILKQDLDNIEFMEQIVSLIGDVKDM 660

  Fly   963 TMVNESVGYYVTGDGLLHCINL------VHSQWGCPISEPLQHVGSVTYDWRGGRVYWTDLARNC 1021
            ...|.:: |:....|.::..:|      |.:....|:     |..::.:||.|..:||:      
Zfish   661 DWYNSTI-YWTNSSGHINWFDLNNRSLSVMTMPSTPV-----HAEALAFDWLGQYLYWS------ 713

  Fly  1022 VVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASF 1086
                                             ..::|:.| |||..:||..:.  ..:..|.|.
Zfish   714 ---------------------------------CNTNQICR-GSTSGQAVEIFL--QADQKILSL 742

  Fly  1087 VLDTQQDQLFWLVKGS-GALRLYRAPLTAGGDSLQMIQQIKGVF---QAVPDSLQLLRPLGALLW 1147
            |:|:....::|..:.| .|.||       .|:..|::.:: .||   :....:|.::.  |.|.|
Zfish   743 VIDSLNAAIYWTTETSVEACRL-------DGEGFQLLDKL-SVFSGKEVAGVTLNMIE--GNLYW 797

  Fly  1148 LERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGH 1212
            |.:.|....|.|:....|.|:.....:.:..:..|:.|                           
Zfish   798 LVQDGSLLNLYRVNISGDRMQKSKAVEFAKWTTSQIFD--------------------------- 835

  Fly  1213 WDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRS 1277
                            |.|||     :.:||..||.:... |:.:|.|....|..|....||:  
Zfish   836 ----------------HQVSY-----YSERLVWLDENKQL-RIQELNQNNSVLMSSNNTLTAF-- 876

  Fly  1278 GDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHISCWV 1342
               :.||....|:                                                    
Zfish   877 ---SVVQKMLKPL---------------------------------------------------- 886

  Fly  1343 GSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYA 1407
                                   ||                  |..|..:.:.|.|..:  ||..
Zfish   887 -----------------------PD------------------GFVSPPVVIPPAVSKI--VLVG 908

  Fly  1408 NAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEV 1472
            ||.|.                              ::.|          .|.|            
Zfish   909 NASFF------------------------------QIHW----------EPSS------------ 921

  Fly  1473 LALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQS 1537
                ||:                ..:.|    |      :..:.||        |:|..||    
Zfish   922 ----VDY----------------GTVFY----C------VVSKEVW--------KNLDPLP---- 944

  Fly  1538 LIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVA 1602
                                                                             
Zfish   945 ----------------------------------------------------------------- 944

  Fly  1603 RQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQ 1667
                                                                             
Zfish   945 ----------------------------------------------------------------- 944

  Fly  1668 AHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEP 1732
                ..:|.:.|                       | |:.|.:|..          :|:|..| |
Zfish   945 ----NMFPTRYC-----------------------H-PVNTFTETV----------INVTRFK-P 970

  Fly  1733 GSEEHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASA 1797
            |:|                   ||:|                                      .
Zfish   971 GAE-------------------LNIT--------------------------------------I 978

  Fly  1798 TPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAG 1862
            ||                                                               
Zfish   979 TP--------------------------------------------------------------- 980

  Fly  1863 THRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLG 1927
                        :|.|.:..:|.|                            :.:|.|||.|   
Zfish   981 ------------FSYWGKGKSTET----------------------------ILITPAGTSD--- 1002

  Fly  1928 SLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDA 1992
                                                                             
Zfish  1003 ----------------------------------------------------------------- 1002

  Fly  1993 PSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPW 2057
                                                                             
Zfish  1003 ----------------------------------------------------------------- 1002

  Fly  2058 AEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEK 2122
                                                                          .:|
Zfish  1003 --------------------------------------------------------------TDK 1005

  Fly  2123 RGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAK---KLLQQSRPSIWSNLSTLQTQQQLMAV 2184
              :|::||::.|..|:..:|.|.:|  :.:|..:.|   |..|.|...|..::. |:..:.|:.:
Zfish  1006 --TLIIAIVSVAVGVTLIILILAVV--IWQRHHKKKDHGKAKQPSSVQIHPDVE-LEYVRGLVGL 1065

  Fly  2185 RNRAF--STTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSE----EPQR-VAIK 2242
            .|..|  |.|.|.|:|..||......|||.|.||||||||||||  .|..|:    ||:| ||||
Zfish  1066 ENGCFAISNTPSRAEIESLPVFPRDCLKLQRLLGSGAFGEVYEG--VTVGSQINGVEPERKVAIK 1128

  Fly  2243 SLRKGASEF--AELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATS 2305
            :|:|.||::  .|.|:||.|||.|.|.||:.|:|:|...|...||:|.||.|||.||||.||.|:
Zfish  1129 TLQKDASDYEKTEFLKEAHLMSQFNHPNILRLLGVCLLNEPHYLILELMEGGDLRSYLRGARPTN 1193

  Fly  2306 TQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFG 2370
            ..:..    ||||.||.:.:|.|.||:|||.|||||||:|.|||||:..| .||..|.|||||||
Zfish  1194 NHKEL----LSLSSLLDISLDAATGCAYLERMHFVHRDIAARNCLVSVRT-YTDPERVVKIGDFG 1253

  Fly  2371 LARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFE 2435
            ||||:||:|||||:|||||||||||||||.||:|...|||||||||.|||||||:.||....|.|
Zfish  1254 LARDVYKNDYYRKKGEGLLPVRWMSPESLTDGIFNKYSDVWAFGVLLWEILTLGKLPYPTYTNHE 1318

  Fly  2436 VLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI---STDLRRTQMASAT 2497
            ||:::..||||..|..|.::||:|::.||...|.:||:|:....|:..:   ..|.|..|...| 
Zfish  1319 VLSYISTGGRLSSPAGCPQRLYNLMMSCWSKQPADRPNFQFLEETMRKLRNYEADKRANQTDGA- 1382

  Fly  2498 ADTVVSCSRPEFKVRFDGQPLEEHREHNER-----PEDENLTLREVPLKDKQLYANEGVSRL 2554
                            ||...:.:....|.     .|||:|.....|     :.:|||::.|
Zfish  1383 ----------------DGHVNQAYLGDEEEVCAGVEEDEDLETGLSP-----VLSNEGLNYL 1423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470 22/84 (26%)
FN3 826..921 CDD:238020 25/94 (27%)
LY 993..1026 CDD:214531 6/32 (19%)
FN3 1292..1374 CDD:214495 2/81 (2%)
FN3 1799..1897 CDD:238020 5/97 (5%)
FN3 1993..2111 CDD:238020 0/117 (0%)
Pkinase_Tyr 2209..2481 CDD:285015 162/278 (58%)
PTKc_c-ros 2213..2483 CDD:270640 160/276 (58%)
ros1XP_009291185.1 FN3 70..151 CDD:238020 20/55 (36%)
FN3 156..244 CDD:238020 26/94 (28%)
FN3 525..618 CDD:238020 28/121 (23%)
Pkinase_Tyr 1092..1362 CDD:285015 162/276 (59%)
PKc_like 1096..1364 CDD:304357 159/274 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170592729
Domainoid 1 1.000 305 1.000 Domainoid score I1346
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2207
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D203310at2759
OrthoFinder 1 1.000 - - FOG0006628
OrthoInspector 1 1.000 - - oto40342
orthoMCL 1 0.900 - - OOG6_108587
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4461
SonicParanoid 1 1.000 - - X5629
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.680

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