Protein Alignment sev and ros1

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_073784362.1
• Gene: ros1 / 245951
• ZFINID: ZDB-GENE-020506-1
• Length: 1408
• Species: Danio rerio
• Alignment Length: 2272
• Identity: 469/2272 - (20%)
• Similarity: 699/2272 - (30%)
• Gaps: 1043/2272 - (45%)

  Fly   376 SSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISA 440
            |..|.. |:...:..|..|.||   |||.|.||......|.:   ..|||:|.|||.|.|.| |:
Zfish    67 SGIWAQ-AENVTESSYTVEQLE---PYTYYTFRVWAVIAETQ---ACSPASPWYQTKPFGLP-SS 123

  Fly   441 PVIEHLMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQ----LQ 501
            |.||::..:....:.|.|.|.....|||.|:.|.|:|      ::..:.|..|..:||.    ..
Zfish   124 PSIENVESISGESVEVRWTPPEKPRGPILGFNLNLTS------NKHKISAATGGNVFSNTFYPTF 182

  Fly   502 AGTNYTLALSMINKQGEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRR------AVMWQSLEPA 560
            ..|.|.::::.:|::|:|.||:..:.|       ||:        ||:.      |..|.||...
Zfish   183 HNTTYRISIAAVNEEGQGSVAEASITT-------PAQ--------VGQDGGRWVFASRWSSLRMR 232

  Fly   561 GENSMIYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESGQ--MVSPAQQL--KLDLGNISSG 621
            .|::..:.:.:.|:|   |:.|..:..:.||.....:.|..|.  .|..|..|  ..||..:.:.
Zfish   233 EEDADFFTTAQCLSD---SRIEGNITGVAVHYNSNHVYFSEGSRIWVKGAGNLTDHSDLKLLHTA 294

  Fly   622 RWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESTQKVGESFDLPVEQLEV--DALNG 684
            ......|:.|||:.|:|:|         |...|....|.:....|..:.:|..:.:.:  |..||
Zfish   295 PLEVTALTVDWLYLRIYYA---------SGGRIHYCGLDDCLSPVDTNVNLSSDAVNIIADPYNG 350

  Fly   685 WIFWRNEESLWRQDL-----HGRMIHRLLRIRQPGWFLVQ-PQHFIIHLMLPQEGKFLE-ISYDG 742
            |::......::|..|     ..:.|..::::.....|:|. |...|::  ..:..:.|. .|.||
Zfish   351 WLYMLLSTGIYRSPLPDVSSQQQEISHIIKMPSVSNFVVSFPNKRIVY--HDRSDQTLNATSLDG 413

  Fly   743 GFKHPLPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLI-----LVEQQGQAASP------ 796
            .|  |:.|....|...|               |::..|:..::     :.:|.||:..|
Zfish   414 LF--PITLYTNVNFEAN---------------SIVYEDNFFMLTNGYAVYKQVGQSQVPTFFEFA 461

  Fly   797 -------SASWPLKNLPDCW----AVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERN 850
                   |.:....||  |:    |.:..||.         ||..|:.|.|:..|.:.|.:||..
Zfish   462 MDCDIIHSENGGFDNL--CYFSTSAQLYPVPR---------KPKDLQVLFGSDKAYVYWNKPESM 515

  Fly   851 PYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTE 915
            ...|..|.::|:|.:. ..:......|||.:......:..||....|.:.|||.:    ||..:.
Zfish   516 MGASPSAWQNWTYAIN-CTMNGLVVMSIREVTSTYATVPDLQSSQHYNVTVRACS----PGGCSR 575

  Fly   916 PLAARTWPLGPHRLRWASRQGSVIHTNE-------LGEGLEVQQ--------EQLERLPG---PM 962
            .|               |.:|:.:|..:       ..:|..::|        ||:..|.|   .|
Zfish   576 SL---------------SYEGTTLHPADEPPYIAAASDGDILKQDLDNIEFMEQIVSLIGDVKDM 625

  Fly   963 TMVNESVGYYVTGDGLLHCINL------VHSQWGCPISEPLQHVGSVTYDWRGGRVYWTDLARNC 1021
            ...|.:: |:....|.::..:|      |.:....|:     |..::.:||.|..:||:
Zfish   626 DWYNSTI-YWTNSSGHINWFDLNNRSLSVMTMPSTPV-----HAEALAFDWLGQYLYWS------ 678

  Fly  1022 VVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASF 1086
                                             ..::|:.| |||..:||..:.  ..:..|.|.
Zfish   679 ---------------------------------CNTNQICR-GSTSGQAVEIFL--QADQKILSL 707

  Fly  1087 VLDTQQDQLFWLVKGS-GALRLYRAPLTAGGDSLQMIQQIKGVF---QAVPDSLQLLRPLGALLW 1147
            |:|:....::|..:.| .|.||       .|:..|::.:: .||   :....:|.::.  |.|.|
Zfish   708 VIDSLNAAIYWTTETSVEACRL-------DGEGFQLLDKL-SVFSGKEVAGVTLNMIE--GNLYW 762

  Fly  1148 LERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGH 1212
            |.:.|....|.|:....|.|:.....:.:..:..|:.|
Zfish   763 LVQDGSLLNLYRVNISGDRMQKSKAVEFAKWTTSQIFD--------------------------- 800

  Fly  1213 WDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRS 1277
                            |.|||     :.:||..||.:... |:.:|.|....|..|....||:
Zfish   801 ----------------HQVSY-----YSERLVWLDENKQL-RIQELNQNNSVLMSSNNTLTAF-- 841

  Fly  1278 GDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQGQEAPMQALEYHISCWV 1342
               :.||....|:
Zfish   842 ---SVVQKMLKPL---------------------------------------------------- 851

  Fly  1343 GSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAPEVQAVPRVLYA 1407
                                   ||                  |..|..:.:.|.|..:  ||..
Zfish   852 -----------------------PD------------------GFVSPPVVIPPAVSKI--VLVG 873

  Fly  1408 NAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEV 1472
            ||.|.                              ::.|          .|.|
Zfish   874 NASFF------------------------------QIHW----------EPSS------------ 886

  Fly  1473 LALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQS 1537
                ||:                ..:.|    |      :..:.||        |:|..||
Zfish   887 ----VDY----------------GTVFY----C------VVSKEVW--------KNLDPLP---- 909

  Fly  1538 LIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVA 1602
                                                                             
Zfish   910 ----------------------------------------------------------------- 909

  Fly  1603 RQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQ 1667
                                                                             
Zfish   910 ----------------------------------------------------------------- 909

  Fly  1668 AHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEP 1732
                ..:|.:.|                       | |:.|.:|..          :|:|..| |
Zfish   910 ----NMFPTRYC-----------------------H-PVNTFTETV----------INVTRFK-P 935

  Fly  1733 GSEEHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASA 1797
            |:|                   ||:|                                      .
Zfish   936 GAE-------------------LNIT--------------------------------------I 943

  Fly  1798 TPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAG 1862
            ||
Zfish   944 TP--------------------------------------------------------------- 945

  Fly  1863 THRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLG 1927
                        :|.|.:..:|.|                            :.:|.|||.|
Zfish   946 ------------FSYWGKGKSTET----------------------------ILITPAGTSD--- 967

  Fly  1928 SLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDA 1992
                                                                             
Zfish   968 ----------------------------------------------------------------- 967

  Fly  1993 PSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPW 2057
                                                                             
Zfish   968 ----------------------------------------------------------------- 967

  Fly  2058 AEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEK 2122
                                                                          .:|
Zfish   968 --------------------------------------------------------------TDK 970

  Fly  2123 RGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAK---KLLQQSRPSIWSNLSTLQTQQQLMAV 2184
              :|::||::.|..|:..:|.|.:|  :.:|..:.|   |..|.|...|..::. |:..:.|:.:
Zfish   971 --TLIIAIVSVAVGVTLIILILAVV--IWQRHHKKKDHGKAKQPSSVQIHPDVE-LEYVRGLVGL 1030

  Fly  2185 RNRAF--STTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSE----EPQR-VAIK 2242
            .|..|  |.|.|.|:|..||......|||.|.||||||||||||  .|..|:    ||:| ||||
Zfish  1031 ENGCFAISNTPSRAEIESLPVFPRDCLKLQRLLGSGAFGEVYEG--VTVGSQINGVEPERKVAIK 1093

  Fly  2243 SLRKGASEF--AELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATS 2305
            :|:|.||::  .|.|:||.|||.|.|.||:.|:|:|...|...||:|.||.|||.||||.||.|:
Zfish  1094 TLQKDASDYEKTEFLKEAHLMSQFNHPNILRLLGVCLLNEPHYLILELMEGGDLRSYLRGARPTN 1158

  Fly  2306 TQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFG 2370
            ..:..    ||||.||.:.:|.|.||:|||.|||||||:|.|||||:..| .||..|.|||||||
Zfish  1159 NHKEL----LSLSSLLDISLDAATGCAYLERMHFVHRDIAARNCLVSVRT-YTDPERVVKIGDFG 1218

  Fly  2371 LARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFE 2435
            ||||:||:|||||:|||||||||||||||.||:|...|||||||||.|||||||:.||....|.|
Zfish  1219 LARDVYKNDYYRKKGEGLLPVRWMSPESLTDGIFNKYSDVWAFGVLLWEILTLGKLPYPTYTNHE 1283

  Fly  2436 VLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI---STDLRRTQMASAT 2497
            ||:::..||||..|..|.::||:|::.||...|.:||:|:....|:..:   ..|.|..|...|
Zfish  1284 VLSYISTGGRLSSPAGCPQRLYNLMMSCWSKQPADRPNFQFLEETMRKLRNYEADKRANQTDGA- 1347

  Fly  2498 ADTVVSCSRPEFKVRFDGQPLEEHREHNER-----PEDENLTLREVPLKDKQLYANEGVSRL 2554
                            ||...:.:....|.     .|||:|.....|     :.:|||::.|
Zfish  1348 ----------------DGHVNQAYLGDEEEVCAGVEEDEDLETGLSP-----VLSNEGLNYL 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996	22/84 (26%)
		FN3	826..921	CDD:238020	25/94 (27%)
		Vgb	992..>1118	CDD:443399	24/126 (19%)
		LY	993..1026	CDD:214531	6/32 (19%)
		FN3	1292..1374	CDD:214495	2/81 (2%)
		fn3	1800..1891	CDD:394996	4/90 (4%)
		FN3	1993..2111	CDD:238020	0/117 (0%)
		PTKc_c-ros	2213..2483	CDD:270640	160/276 (58%)
ros1	XP_073784362.1	None