DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and igf1ra

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_694500.1 Gene:igf1ra / 245701 ZFINID:ZDB-GENE-020503-1 Length:1405 Species:Danio rerio


Alignment Length:1182 Identity:304/1182 - (25%)
Similarity:450/1182 - (38%) Gaps:357/1182 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1527 KDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELE-----WATVQPLIRL---HA-GSLE- 1581
            |.:.::..||||......:|:.:....||.|:  .||||     ..||...:|:   |. |||. 
Zfish   338 KTIDSVDAAQSLQGCTVIKGNLQINIRRGNNI--ASELESFMGLIQTVTGYVRIKHTHTLGSLSF 400

  Fly  1582 -------PGSE------TLNLVDNQGKLCVYDVAR----------------QLCTASALRAQLNL 1617
                   .|.|      ..:.|||.....::|..:                :|| .|.:|   .:
Zfish   401 LKSLRYIVGEELVDNTYAFHAVDNHNLQYLWDWTQHNLTIRTGKLYFRFNPKLC-MSEIR---KM 461

  Fly  1618 LGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAH-NYQAYPPKNCLL 1681
            ..:.|:..::|:|          .:|:.|.|.....|.::......:..:.. .::.|.|     
Zfish   462 WEKTSVREKMAED----------DVRSNGERASCESYILKFRSNHTQSTRIKLTWERYRP----- 511

  Fly  1682 LPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHGMEPLGQ 1746
                          .:.|.|  :..|...::.|..        |:|        |.| |.:..| 
Zfish   512 --------------PDYRDL--ISFIVYYKEAPFQ--------NIT--------EFD-GQDGCG- 542

  Fly  1747 WLLGAGESLNLTDL-LPFTRYRVSGILSSFYQKKLALPTLVLAPLE------------------- 1791
                 ..|.|:.|: ||              |:|...|.::|:||:                   
Zfish   543 -----SNSWNMVDVDLP--------------QEKSIDPGVLLSPLKPWTQYAIFVKAVTLVVEDK 588

  Fly  1792 -----------LLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQEL-DGEN 1844
                       :.|.::.||.|.:......|...|.|.|.||........:|.|.|||:. |||.
Zfish   589 HVGGAKSEVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPPIAPNGNKTFYVLRWQQQAEDGEL 653

  Fly  1845 VQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLE 1909
            .|  ..:.:.|.::..    |::......     ::....||||                     
Zfish   654 YQ--HNYCSKELKIPI----RISATSLSD-----MEGETKPTKS--------------------- 686

  Fly  1910 LGPYSLSLTWAGTPDPLGSLQ--LECRSSAEQLRRNVAGNHTKMVVE---------PLQP-RTRY 1962
                          |..|..:  ..|..:.|.|:........:.|.|         |..| |.| 
Zfish   687 --------------DVAGGEKGCCPCPKTKEDLKAEAEDRSYRKVFENFLHNSIFTPRPPDRKR- 736

  Fly  1963 QCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEE-----------------VFR 2010
              |.|:|.|   .:.|..|.:.....|....:||..|:.|:...|                 |:|
Zfish   737 --RDLMGVA---NSTLVSGVSRNISVLESNITQPELPEKEYPFSEGKVHTEFMEIHNLRPFTVYR 796

  Fly  2011 V-----TWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPW------------- 2057
            :     .:...|.:.|.......:......||.....:.|...|..:..|.|             
Zfish   797 IDIHACNYEVHRCSAAAFVFSRTKPADKADDIPGSVTQERDEKGEGIVLLRWPEPLHPNGLILMY 861

  Fly  2058 ---------AEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERV 2113
                     ||:...|..|........:||.:....:|:     ||||.||. |.|.::|.    
Zfish   862 EIKYRLGTEAEKHECVSRQQYKVLRGAQLSNLASGNYSA-----RVRATSLA-GNGSWTEP---- 916

  Fly  2114 AEPFVSPEKR---GSLVLAIIAPAAIVSSCVLALVLVRKVQKR----RLRAKKLLQQSRPSIWSN 2171
            ...:|.|.||   .:|.:|||.|..::...:..:|.|..|.|:    |:....|.....|..:| 
Zfish   917 VSFYVPPPKRNYDNALYVAIIIPVIVLLLLLFVIVAVIIVTKKRNSDRIGNGVLYASVNPEYFS- 980

  Fly  2172 LSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLKTED 2232
                            .|...:.|         .|    .::.:.|.||.|:||.||||..|...
Zfish   981 ----------------PFEMYVPD---------EWEVAREKITMCRELGQGSFGMVYEGIAKGVV 1020

  Fly  2233 SEEPQ-RVAIKSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDL 2294
            .:||: |||||::.:.||  |..|.|.||.:|..|...::|.|:|:....:...:|||.|..|||
Zfish  1021 KDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDL 1085

  Fly  2295 LSYLRAARA----TSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTEST 2355
            .|:||:.|:    :|:|...|     |.:::.|..::|:|.:||....|||||||.|||:|.|..
Zfish  1086 KSHLRSLRSKEQGSSSQSLPP-----LKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1145

  Fly  2356 GSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEI 2420
                   ||||||||:.||||::|||||.|:|||||||||||||.||:|||.||||:|||:.|||
Zfish  1146 -------TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEI 1203

  Fly  2421 LTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAIS 2485
            .||.:|||...:|.:||..|.|||.|.:|..|.:.|:.|:.:||:.:|..||||....|   :|.
Zfish  1204 ATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIN---SIK 1265

  Fly  2486 TDLRRTQMASATADTVVSCSRPEFK-VRFDGQPLEEHREHNERPEDENL-----TLREVPLKDKQ 2544
            .:|                 .|.|: |.|      .:.|.|:.|:.|.|     .:..|||..:.
Zfish  1266 EEL-----------------EPPFREVSF------FYSEENKPPDTEELDMEVENMENVPLDPRS 1307

  Fly  2545 LYA-----NEGV 2551
            ..|     |.|:
Zfish  1308 TLAPSSQGNTGI 1319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 24/98 (24%)
FN3 1993..2111 CDD:238020 31/161 (19%)
Pkinase_Tyr 2209..2481 CDD:285015 133/278 (48%)
PTKc_c-ros 2213..2483 CDD:270640 133/276 (48%)
igf1raNP_694500.1 Recep_L_domain 51..167 CDD:279382
Furin-like 182..333 CDD:279142
FU 235..275 CDD:214589
Recep_L_domain 351..465 CDD:279382 25/119 (21%)
FN3 497..602 CDD:238020 23/162 (14%)
FN3 607..>651 CDD:238020 14/43 (33%)
FN3 844..921 CDD:238020 18/86 (21%)
PTKc_IGF-1R 990..1266 CDD:133193 135/290 (47%)
Pkinase_Tyr 997..1264 CDD:285015 133/281 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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