DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and insrb

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_001116701.1	Gene:	insrb / 245700	ZFINID:	ZDB-GENE-020503-4	Length:	1348	Species:	Danio rerio

Alignment Length:	1139	Identity:	288/1139 - (25%)
Similarity:	453/1139 - (39%)	Gaps:	286/1139 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1575 LHAGSLEP----GSETLNLVDNQGKLCVYDVAR--QLCT----------ASALRA--------QL 1615
            :|.|:..|    |..|:|   :....|:....|  ::||          |.|||.        .:
Zfish   297 IHNGACIPECPSGYTTVN---STSLTCMPCTGRCPKVCTGVQTVDSVTAAQALRGCTVLNGSLII 358

  Fly  1616 NLLGEDSIA-------GQLAQDSGYL-----YAV-------------------KNWSIRAYGRRR 1649
            .:.|.:|||       |||.:.:|||     ||:                   .|:|..|..  .
Zfish   359 KISGGNSIAAELESSLGQLEEITGYLTIRRAYALVSLSFLRKLHLIRGETLDGGNYSFHAMD--N 421

  Fly  1650 QQLEYTVELEPEEVRLLQAHNYQAYPPKNC----LLLPSSGGSLLKATD---------CEEQRCL 1701
            |.|....:.....:.:|:.........|.|    |.:..:.|:..:..|         ||..  :
Zfish   422 QNLRQLWDWNKHNLTILKGRMKFIQNGKLCKSEILRMEQATGTKNRMNDISNEKDQSYCESH--I 484

  Fly  1702 LHLPMITASEDCPLPIPGVRYQL-----------NLTLAKEP---GSEEHDHGMEPLG--QWLL- 1749
            |....|....|..|    :|::.           .:.|.||.   ...|:| |.:..|  .|.:
Zfish   485 LKFTQIRTMSDKIL----IRWESFWPSDFRDLLGFMVLYKEAPHRNVTEYD-GQDACGSNSWAIA 544

  Fly  1750 --------GAGESLN----LTDLLPFTRYRV---SGILSSFYQKKLALPTLVLAPLELLTASATP 1799
                    ..|:.:.    :..|.|:|:|.|   :.:.:|...:.....|.::......|..:.|
Zfish   545 DVEPPQRPSEGKEVEPGYLIMPLKPWTQYAVMVKAQLAASEDHQVRGAKTEIIYVRTNATRPSVP 609

  Fly  1800 SPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQEL------------------------ 1840
            ..|.::|   .|..::.:.|.||........:|.::.|::.
Zfish   610 LDPHSWS---NSSSQIILKWKPPSDPNGNITHYIIYCQKQSEDITHYKFDYCQQGMKVPSHTPTH 671

  Fly  1841 -DGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPE 1904
             |.|..|...:.|..:::......       |.:...|..:|..|..:......||...|...|.
Zfish   672 HDVEEDQKLNQTEVPDQKGHCCAC-------PKTEMQLKKEAEETEFRKTFENYLHNEVFEPRPH 729

  Fly  1905 LQLLELGPYSLSL-TWAGTPDPLGSLQLECRSSAEQLRRNV--AGNHTKMVVEPLQPRTRYQCRL 1966
            .:...:|..:.:| .:..||..:.:.........|:.|:.|  |.:...||:..|...|.||..:
Zfish   730 RRRRSVGVANATLPNFGTTPTIIPNFPTTSIPEEEKSRKMVFKASSKEAMVISNLLHFTSYQIEI 794

  Fly  1967 LLGYAAT----PG---APLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIA 2024
               :|..    ||   .|.|.....:.|...|..::|...:......:|..:.|...:.....|.
Zfish   795 ---HACNDPTDPGRCSMPTYVKARTLPELKADVIAEPVTHEFFPDEPDVVYIRWKEPKTPNGMII 856

  Fly  2025 LYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRL 2089
            ||.::.|:                               :.|.:.|....:.:|  .:..|..||
Zfish   857 LYEVKYLR-------------------------------MSDNYEDQICVSRIS--YEKNHGYRL 888

  Fly  2090 LL-------FRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLV 2147
            .:       .||||.||. |.|.:::.:.     |...::..|:.:.|     |::.|:..||::
Zfish   889 RVGHPGNYSVRVRATSLA-GNGSWTDPAY-----FYVQDREMSMKIVI-----ILAICIFLLVIL 942

  Fly  2148 RKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINW----SQ 2208
            ..|....|:.|:....:.|              |:|..|..:   :|..|: .:|. .|    .:
Zfish   943 ASVGYFVLKKKQTEGPTGP--------------LIASSNPEY---ISANDV-YIPD-EWEVPREK 988

  Fly  2209 LKLLRFLGSGAFGEVYEGQLKTEDSEEPQ-RVAIKSLRKGAS--EFAELLQEAQLMSNFKHENIV 2270
            :.::|.||.|:||.||||..|.....||. |||:|::.:.||  |..|.|.||.:|..|...::|
Zfish   989 ITVMRELGQGSFGMVYEGIAKDIIKGEPDTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVV 1053

  Fly  2271 CLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQ---EPQPTAGLSLSELLAMCIDVANGCS 2332
            .|:|:....:...::||.|..|||.||||:.|..:..   .|.||    |.|::.|..::|:|.:
Zfish  1054 RLLGVVSKGQPTLVVMELMTHGDLKSYLRSLRPDAENNPGSPPPT----LKEMIQMSAEIADGMA 1114

  Fly  2333 YLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPE 2397
            ||....|||||||.|||:|.|.       .||||||||:.||||::|||||.|:||||||||:||
Zfish  1115 YLNAKKFVHRDLAARNCMVAED-------YTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE 1172

  Fly  2398 SLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLL 2462
            ||.||:||..||.|:|||:.|||.||.:|||...:|.:||..|.:||.|.:|..|.|::::|:.:
Zfish  1173 SLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPENCPERMHNLMQM 1237

  Fly  2463 CWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEF-KVRFDGQPLEEHREHNE 2526
            ||:.:|..||:|   :..:..|..||                 .|.| :|.|      .:.|.|:
Zfish  1238 CWQYNPKMRPTF---HEIIEMIKEDL-----------------HPTFQEVSF------FYSEENK 1276

  Fly  2527 RPEDENL-----TLREVPLKDKQLYA--NEGVSR 2553
            .||.|..     .:..:|| |...|:  .|..||
Zfish  1277 APESEEFDMDFENMESIPL-DPSSYSQREESHSR 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	19/122 (16%)
		FN3	1993..2111	CDD:238020	21/124 (17%)
		Pkinase_Tyr	2209..2481	CDD:285015	127/277 (46%)
		PTKc_c-ros	2213..2483	CDD:270640	127/275 (46%)
insrb	NP_001116701.1	Recep_L_domain	45..157	CDD:279382
		Furin-like	173..329	CDD:279142	8/34 (24%)
		FU	226..273	CDD:238021
		Recep_L_domain	348..462	CDD:279382	21/115 (18%)
		FN3	606..>649	CDD:238020	9/45 (20%)
		FN3	838..919	CDD:238020	21/119 (18%)
		PTKc_InsR	982..1269	CDD:133192	134/317 (42%)
		Pkinase_Tyr	989..1256	CDD:285015	127/280 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010