DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and insra

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_005171317.1 Gene:insra / 245699 ZFINID:ZDB-GENE-020503-3 Length:1362 Species:Danio rerio


Alignment Length:1160 Identity:289/1160 - (24%)
Similarity:451/1160 - (38%) Gaps:318/1160 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1575 LHAGSLEP---------GSETLNLVDNQG---KLCV-YDVARQLCTASALRA--------QLNLL 1618
            :|.|:..|         .|.|||.....|   |:|: ......:..|.|||.        .:|:.
Zfish   305 IHNGACIPECPSGYTTVNSTTLNCTPCAGLCPKVCMGLKTVDSVTAAQALRGCTVINGSLVINIR 369

  Fly  1619 GEDSIA-------GQLAQDSGYL--------------------------------YAVKNWSIR- 1643
            |.::||       |||.:.:|||                                ||:.|.::| 
Zfish   370 GGNNIAAELEANLGQLEEITGYLTVRHSYALVSLSFLRKLRIIHGETQEVGNYSFYALDNQNLRQ 434

  Fly  1644 ---------AYGRRRQQLEYTVELEPEEVRLLQ----AHNYQAYPPKNCLLLPSSGGSLLKATDC 1695
                     ...:.|....:..:|...|:|.::    ..|.|.   ||.::..::|..    ..|
Zfish   435 LWDWSKHNLTIQQGRMFFHHNSKLCMSEIRRMEEVTGTKNRQT---KNDIVSKTNGDQ----ASC 492

  Fly  1696 EEQRCLLHLPMITASEDCPL-------PIPGVRYQLN-LTLAKEP--------------GS---- 1734
            |.:  :|....|:...|..:       | |..|..|. :.|.||.              ||    
Zfish   493 ESK--VLKFTRISTLSDKIIIKWEAFWP-PDFRDLLGFMVLYKEAPYKNVTEFDGQDACGSNSWV 554

  Fly  1735 -------------EEHDHG-----MEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSS--FYQKK 1779
                         :||:.|     ::|..|:.:.....|:.:|     .::|.|..|.  :.:..
Zfish   555 IADVDPPPRATEGKEHEPGYLIFPLKPWTQYAIMVKTQLSASD-----EHQVHGAKSEIIYVRTN 614

  Fly  1780 LALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGEN 1844
            ...|::.|.|:....:|:                ::.:.|.||........:|.:..||:.:...
Zfish   615 ATKPSVPLDPISSSNSSS----------------QIILKWKPPNDPNGNITHYLVFCQQQPEASE 663

  Fly  1845 V----------------------QDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTK 1887
            :                      ::.::|    .:.|..|........|.:...|..:|..|..:
Zfish   664 LYKFDYCQKGMKLPTRAPTQVDNEEEQKW----NQTEEQGPDSRCCACPKTEKQLKKEAEETEYR 724

  Fly  1888 SNSSERLHVRSFAELPELQ---LLELGPYSLSLTWAGTPD--PLGSLQLECRSSAEQLRRN---- 1943
            ......||...|...|..|   |:.:...:.|..:. ||.  |.||   ..||..|:...|    
Zfish   725 KTFENYLHNEVFELRPSRQRRSLVGIANRTSSRLFT-TPSSLPNGS---ATRSPEEEAEANKISL 785

  Fly  1944 VAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEV 2008
            :.......|:..|:..|.||..:   :|...|:.....:...|.:....|.:.....:..|..||
Zfish   786 IVQAKESTVISNLRHFTSYQIEI---HACNHGSDPTRCSMAAYVSARTMPEEKADDIVGKITCEV 847

  Fly  2009 F----RVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWL 2069
            |    .:.|...:.....|.||         ::..:|.       |..|:|    ...|....::
Zfish   848 FEYSVHIRWIEPKAPNGMIILY---------EVHYKRL-------GDTEEL----HHCVSRKNYI 892

  Fly  2070 DFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESE-RVAEPFVSPEKRGSLVLAIIAP 2133
                 .:..|.::.:|.....: |:||.||. |.|.::|.:. .|.:..|.|    |.||.|:..
Zfish   893 -----ADGGCKLRVVHPGNYTV-RIRATSLA-GNGSWTEPTHFYVQDLRVDP----SNVLKIVIG 946

  Fly  2134 AAIVSSCVLALVLV----RKVQKRRLRAK--KLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTT 2192
            ..|   |...|:|:    ..|:|::....  :|.....|..:|.....:..:.            
Zfish   947 PVI---CFFLLLLLCVGFYIVKKKQTEGPTGRLYTSPNPEYFSPDEVYEPDEW------------ 996

  Fly  2193 LSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQ-RVAIKSLRKGAS--EFAEL 2254
                      ::...::.|||.||.|:||.||||..|.....|.| |||:|::.:.||  |..|.
Zfish   997 ----------EVPREKITLLRELGQGSFGMVYEGNGKDIVKGESQTRVAVKTVNESASLRERIEF 1051

  Fly  2255 LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQ---EPQPTAGLS 2316
            |.||.:|..|...::|.|:|:....:...::||.|..|||.|:||:.|..|..   .|.||    
Zfish  1052 LNEASVMKAFSCHHVVRLLGVVSKGQPTLVVMELMTHGDLKSFLRSLRPDSENNPGRPPPT---- 1112

  Fly  2317 LSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY 2381
            |.|::.|..::|:|.:||....|||||||.|||:|.|..       ||||||||:.||||::|||
Zfish  1113 LKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDL-------TVKIGDFGMTRDIYETDYY 1170

  Fly  2382 RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRL 2446
            ||.|:||||||||:||||.||:||..||.|:|||:.||:.||.:|||...:|.:||..|.|||.|
Zfish  1171 RKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEVSTLAEQPYQGLSNEQVLKFVMEGGYL 1235

  Fly  2447 QQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEF-K 2510
            .:|..|.::|::|:.:||..:|..||:|:   ..:..:..||                 .|.| :
Zfish  1236 DRPDNCADRLHNLMQMCWHYNPKMRPTFQ---EIIEMLREDL-----------------HPSFQE 1280

  Fly  2511 VRFDGQPLEEHREHNERPEDENL-----TLREVPLKDKQLYA--------NEGVS 2552
            |.|      .:.|.|:.||.|..     .:..:|| |...|:        :||.|
Zfish  1281 VSF------FYSEENKPPETEEFDMDLENMESIPL-DPSSYSQRECCLDGDEGSS 1328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 15/119 (13%)
FN3 1993..2111 CDD:238020 24/121 (20%)
Pkinase_Tyr 2209..2481 CDD:285015 129/277 (47%)
PTKc_c-ros 2213..2483 CDD:270640 127/275 (46%)
insraXP_005171317.1 Recep_L_domain 53..165 CDD:279382
Furin-like 179..337 CDD:279142 8/31 (26%)
FU 234..281 CDD:238021
Recep_L_domain 356..470 CDD:279382 18/113 (16%)
FN3 618..>660 CDD:238020 10/57 (18%)
FN3 851..930 CDD:238020 19/105 (18%)
PTKc_InsR 996..1283 CDD:133192 134/339 (40%)
Pkinase_Tyr 1003..1270 CDD:285015 129/280 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

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