Protein Alignment sev and Met

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_113705.2
• Gene: Met / 24553
• RGDID: 3082
• Length: 1382
• Species: Rattus norvegicus
• Alignment Length: 746
• Identity: 190/746 - (25%)
• Similarity: 289/746 - (38%)
• Gaps: 217/746 - (29%)

  Fly  1852 EAHERRLETAGTHRLTGIKPG----SGYSLWVQAHATPTKSNSSERLHVRSFAEL-----PELQL 1907
            |.|..:...:|...:|||...    |...|.::.|....  |.:.....||.:|:     |.||.
  Rat   747 EIHPTKSFISGGSTITGIGKNLNSVSTPKLVIEVHDVGV--NYTVACQHRSSSEIICCTTPSLQQ 809

  Fly  1908 LELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKM--VVEPL-QPRTRYQCRLLLG 1969
            |:                   |||..::.|..|...:...|..:  |.:|: :|   ::..:::.
  Rat   810 LD-------------------LQLPLKTKAFFLLDGILSKHFDLTYVHDPMFKP---FEKPVMIS 852

  Fly  1970 YAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQAR 2034
            .          |...|.|..|| ...|     |.:..||.:|      ||
  Rat   853 M----------GNENVVEIKGD-DIDP-----EAVKGEVLKV------GN--------------- 880

  Fly  2035 SDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSL 2099
                           .|.|.|.|..|               .|.|.|.|      .|.::....|
  Rat   881 ---------------KSCENLHWHSE---------------ALLCTVPS------DLLKLNGGEL 909

  Fly  2100 EHGWGPYSEESERVAEPFVSPEKR-GSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQ 2163
            ...| ..:..|..:.:..|.|::. ..|::..::.:.:|.......:.:||.:.:.|.::.:...
  Rat   910 NIEW-KQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLVSGLFLWLRKRKHKDLGSELVRYD 973

  Fly  2164 SR--------------------------------------PSIWSNLSTLQTQQQLMAVRNRAFS 2190
            :|                                      |:...|.:..|.|..|
  Rat   974 ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPL--------- 1029

  Fly  2191 TTLS------DADI--------------ALLPQ---------INWSQLKLLRF---LGSGAFGEV 2223
            |.||      |:||              ||.|:         |..|.| ::.|   :|.|.||.|
  Rat  1030 TDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSL-IVHFNEVIGRGHFGCV 1093

  Fly  2224 YEGQLKTEDSEEPQRVAIKSLRK--GASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISL-I 2285
            |.|.|...|.:: ...|:|||.:  ...|.::.|.|..:|.:|.|.|::.|:|||..:|...| :
  Rat  1094 YHGTLLDSDGKK-IHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVV 1157

  Fly  2286 MEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCL 2350
            :.:|:.|||.:::|    ..|..|      ::.:|:...:.||.|..||....|||||||.|||:
  Rat  1158 LPYMKHGDLRNFIR----NETHNP------TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCM 1212

  Fly  2351 VTESTGSTDRRRTVKIGDFGLARDIYKSDYY---RKEGEGLLPVRWMSPESLVDGLFTTQSDVWA 2412
            :       |.:.|||:.|||||||:|..:||   .|.| ..|||:||:.|||....|||:||||:
  Rat  1213 L-------DEKFTVKVADFGLARDMYDKEYYSVHNKTG-AKLPVKWMALESLQTQKFTTKSDVWS 1269

  Fly  2413 FGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRC 2477
            ||||.||::|.|..||...|.|::..::.:|.||.||..|.:.||.::|.||......||||...
  Rat  1270 FGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSEL 1334

  Fly  2478 YNTLHAISTDLRRTQMASATADTV-VSCSRP 2507
            .:.:.:|.:...........|..| |.|..|
  Rat  1335 VSRISSIFSTFIGEHYVHVNATYVNVKCVAP 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	10/42 (24%)
		FN3	1993..2111	CDD:238020	19/117 (16%)
		PTKc_c-ros	2213..2483	CDD:270640	108/278 (39%)
Met	NP_113705.2	Sema	25..517	CDD:472829
		PSI	520..562	CDD:214655
		IPT_plexin_repeat1	564..657	CDD:238585
		IPT_plexin_repeat2	658..741	CDD:238584
		IPT	743..838	CDD:472823	23/111 (21%)
		IPT	839..>903	CDD:214657	24/139 (17%)
		PTKc_Met_Ron	1083..1344	CDD:270649	108/279 (39%)
		Interaction with RANBP9. /evidence=ECO:0000250	1213..1382		64/161 (40%)
		Interaction with MUC20. /evidence=ECO:0000250	1321..1360		8/38 (21%)