DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and FRK

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_002022.1 Gene:FRK / 2444 HGNCID:3955 Length:505 Species:Homo sapiens


Alignment Length:534 Identity:142/534 - (26%)
Similarity:231/534 - (43%) Gaps:131/534 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  2023 IALYNLEALQARSDIRRR------------------RRRRRRNSGGSLEQLPWAEEPVVVEDQ-- 2067
            :||::.:|..| .|:..|                  |...:|..|.|.:...:.....|.||:  
Human    48 VALFDYQARTA-EDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSL 111

  Fly  2068 ----WLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEE---SERVAEPFVSPEKRGS 2125
                |.       ...|.:|....:||               |||.   |..:.|   |..::|.
Human   112 QAEPWF-------FGAIGRSDAEKQLL---------------YSENKTGSFLIRE---SESQKGE 151

  Fly  2126 LVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFS 2190
            ..|:::..|.:                :..|.|:|         .......|::::.:..|...|
Human   152 FSLSVLDGAVV----------------KHYRIKRL---------DEGGFFLTRRRIFSTLNEFVS 191

  Fly  2191 --TTLSDA------------------DIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLKTE 2231
              |..||.                  |::......|    :.::||:.||||.||||:||   ..
Human   192 HYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEG---LW 253

  Fly  2232 DSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLS 2296
            ::..|  ||:|:|:.|:.:..:.|:|||:|.|.:|..::.|..:|...:.|.:|.|.|..|.|..
Human   254 NNTTP--VAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQE 316

  Fly  2297 YLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRR 2361
            ||:....:.         :.|::.:.|...||:|.:|||..:::|||||.||.||.|       .
Human   317 YLQNDTGSK---------IHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGE-------H 365

  Fly  2362 RTVKIGDFGLARDIYK---SDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTL 2423
            ...|:.|||||| ::|   .|.|....|..|||:|.:||::....|:.:||||:||:|.:||:|.
Human   366 NIYKVADFGLAR-VFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITY 429

  Fly  2424 GQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDL 2488
            |:.||:.....:|:..:.:..||.||..|.::.|:::|.||..:|.|||:|    .||.....|.
Human   430 GKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF----ETLRWKLEDY 490

  Fly  2489 RRTQMASATADTVV 2502
            ..|..:.:.|:..:
Human   491 FETDSSYSDANNFI 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020 21/114 (18%)
PTKc_c-ros 2213..2483 CDD:270640 99/272 (36%)
FRKNP_002022.1 SH3_Src_like 47..104 CDD:212779 10/56 (18%)
SH2_Src_Frk 112..207 CDD:199831 23/144 (16%)
PTKc_Frk_like 225..494 CDD:270653 103/294 (35%)
Blue background indicates that the domain is not in the aligned region.

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