Protein Alignment sev and Insrr

DIOPT Version :9

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_006501514.1
• Gene: Insrr / 23920
• MGIID: 1346037
• Length: 1313
• Species: Mus musculus
• Alignment Length: 1109
• Identity: 283/1109 - (25%)
• Similarity: 424/1109 - (38%)
• Gaps: 332/1109 - (29%)

  Fly  1527 KDLVALPQAQSLIWLEYEQGSPRNGSLRGRNL------TDGSELE--WATV-----QPLIRLHAG 1578
            :|||.....:..:.|...||......|: |||      |...:::  :|.|     :.|..:...
Mouse   342 QDLVGCTHVEGNLILNLRQGYNLEPELQ-RNLGLVETITGFLKIKHSFALVTLGFFKNLKLIRGD 405

  Fly  1579 SLEPGSETLNLVDNQG-------------------------KLC---VYDVA------------- 1602
            |:..|:.||.::|||.                         :||   :|.:.
Mouse   406 SMVDGNYTLYVLDNQNLQQLGSWVTAGLTIPVGKIYFAFNPRLCLEHIYQLEEVTGTRGRQSKAE 470

  Fly  1603 --------RQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELE 1659
                    |..|....||...||..||.|             :..|.               ..|
Mouse   471 INPRTNGDRAACQTRTLRFVFNLTEEDRI-------------LLRWE---------------RYE 507

  Fly  1660 PEEVRLLQAH--NYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHL-PMITASEDCPLPIPGVR 1721
            |.|.|.|.:.  .|:..|.:|             ||:        |: |....::...|    :.
Mouse   508 PLEARDLLSFIVYYKESPFQN-------------ATE--------HVGPDACGTQSWNL----LD 547

  Fly  1722 YQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLV 1786
            .:|.|:..:|||                     :.|..|.|:|:|.|       :.:.:.|.|..
Mouse   548 VELPLSRTQEPG---------------------VTLAPLKPWTQYAV-------FVRAITLTTAE 584

  Fly  1787 LAP--------LELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQ-ELDG 1842
            .:|        :.|.|..|.|:.|::......|...|.|.|.||.|......||.:.||: ..||
Mouse   585 DSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQRLAEDG 649

  Fly  1843 E-NVQD------RREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFA 1900
            : .:.|      |....:|:.|.:....  ....:|..|  .....|:.|.::
Mouse   650 DLYINDYCHRGLRLPTSSHDTRFDREDP--ALEAEPEQG--CCPCQHSPPGQA------------ 698

  Fly  1901 ELPELQLLEL-------GPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVA------GNHTKMV 1952
             ||.|:..|:       .....::|....|..:.|:....:..:|:.||...      .|....:
Mouse   699 -LPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSERHRREAGLLRLGKNNSDFEI 762

  Fly  1953 VEPLQPRTRYQCRLLLGYAATPGAPLY-------HGTAEVYETLG---------------DAPSQ 1995
            .|...||.|         |...|...:       |.......|:|               :|...
Mouse   763 QEDKVPRER---------AILSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGI 818

  Fly  1996 PGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLE-----ALQARSDIRRRRRRRRRNSGGSLEQL 2055
            |||            |.|.||  ..:.:.|:.||     .|..:.:|:.||
Mouse   819 PGK------------VAWKAA--GKSSVTLHWLEPPDPNGLILKYEIKYRR-------------- 855

  Fly  2056 PWAEEPVVVEDQWLDFCNT--TELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFV 2118
             ..||..|:....|.:...  ..|:.:....:|:     :|||.||. |.|.:::..........
Mouse   856 -LGEEATVLCVSRLRYAKVGGVHLALLPPGNYSA-----KVRATSLA-GNGSWTDGVTFYITDLE 913

  Fly  2119 SPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMA 2183
            ..:..|..:...:.|...:....||.:.....:||.                  |||.|     :
Mouse   914 EEDTGGMRIFLTVTPVGFMLLVTLAALGFFYSRKRN------------------STLYT-----S 955

  Fly  2184 VRNRAFSTTLSDADIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLK-TEDSEEPQRVAIKS 2243
            |....||     |....:|. .|    .|:.::|.||.|:||.||||..: .|..||...||:|:
Mouse   956 VNPEYFS-----ASHMYVPD-EWEVPREQIAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKT 1014

  Fly  2244 LRKGAS--EFAELLQEAQLMSNFKHENI-------------VCLVGICFDTESISLIMEHMEAGD 2293
            :.:.||  |..|.|:||.:|..||..::             |.|:|:....:...:|||.|..||
Mouse  1015 VNELASARERVEFLKEASVMKAFKCHHVRQEGLPQRSLSSQVRLLGVVSQGQPTLVIMELMTRGD 1079

  Fly  2294 LLSYLRAARATSTQE---PQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTEST 2355
            |.|:||:.|..:...   |||    :||:::.|..::|:|.:||....|||||||.|||:|::..
Mouse  1080 LKSHLRSLRPEAENNPGLPQP----ALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDF 1140

  Fly  2356 GSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEI 2420
                   ||||||||:.||:|::|||||.|:||||||||:||||.||:|||.||||:|||:.|||
Mouse  1141 -------TVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEI 1198

  Fly  2421 LTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAIS 2485
            :||.:|||...:|.:||..|.:||.|::...|..:|..|:.|||:..|..||:|   .:.|..|.
Mouse  1199 VTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTF---VHILDRIQ 1260

  Fly  2486 TDLR 2489
            .:||
Mouse  1261 DELR 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	23/105 (22%)
		FN3	1993..2111	CDD:238020	27/124 (22%)
		Pkinase_Tyr	2209..2481	CDD:285015	127/290 (44%)
		PTKc_c-ros	2213..2483	CDD:270640	128/288 (44%)
Insrr	XP_006501514.1	Recep_L_domain	47..157	CDD:366426
		Furin-like	173..329	CDD:366287
		Recep_L_domain	346..459	CDD:366426	21/113 (19%)
		FN3	494..600	CDD:238020	32/186 (17%)
		FN3	605..>649	CDD:238020	13/43 (30%)
		FN3	819..908	CDD:238020	27/123 (22%)
		PTKc_InsR_like	972..1261	CDD:173625	131/302 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910