DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and ALK

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_004295.2 Gene:ALK / 238 HGNCID:427 Length:1620 Species:Homo sapiens


Alignment Length:1608 Identity:376/1608 - (23%)
Similarity:568/1608 - (35%) Gaps:557/1608 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1242 RLQTLDLSTPF---------ARLTQLPQAQLQLK--------------------ISITPRTAWRS 1277
            |||...|:..|         ||...||.:..:||                    :...|..:|.:
Human    48 RLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTA 112

  Fly  1278 GDTTRVQLTTPPVAPSQPRRL-RVF----VERLATALQ---EANVSAVLRWDAPEQGQEAPMQAL 1334
            |..          ||::.|.| ||.    |.:|..|.|   |....|:|.......| ||.:..|
Human   113 GSP----------APAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPG-EAAVGLL 166

  Fly  1335 EYHI----SCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVA 1395
            ::::    |.|:        |..:..|..|   |.|:         :.|:.....|..|.|:..:
Human   167 QFNLSELFSWWI--------RQGEGRLRIR---LMPE---------KKASEVGREGRLSAAIRAS 211

  Fly  1396 PEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGS 1460
            .     ||:|:   :..|                         .|...|       |..|::|..
Human   212 Q-----PRLLF---QIFG-------------------------TGHSSL-------ESPTNMPSP 236

  Fly  1461 APAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDL-CNFEGKILQGERVWSTPRGR 1524
            :|        :.....:.||.:..:        |..:...|..| |:|:   ...|..:|.|   
Human   237 SP--------DYFTWNLTWIMKDSF--------PFLSHRSRYGLECSFD---FPCELEYSPP--- 279

  Fly  1525 LLKDLVALPQAQSLIW--LEYEQGSPRN-----GSLRGRNLTDGSELEWATVQPLIRLHAGS--- 1579
             |.||    :.||..|  :..|:.|..:     |:.|.:.:..||.|       |:...|.|   
Human   280 -LHDL----RNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFL-------LLNTSADSKHT 332

  Fly  1580 -LEP----GSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKN 1639
             |.|    .||...|        ...|.|.|..:....|||....|.:....|....|    ...
Human   333 ILSPWMRSSSEHCTL--------AVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPG----KHG 385

  Fly  1640 WSI--RAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNC---------LLLPSS----GGSL 1689
            |::  ...||........:|......|.|.|.::.|.  |||         :.|.||    .|::
Human   386 WTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFAL--KNCSEGTSPGSKMALQSSFTCWNGTV 448

  Fly  1690 LKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHGME-PLG-------- 1745
            |:.    .|.|..|       :||                 ..|.:|.....: |:|        
Human   449 LQL----GQACDFH-------QDC-----------------AQGEDESQMCRKLPVGFYCNFEDG 485

  Fly  1746 --QWLLGAGESLNLTDLLPFT-RYRVSGILSSFYQ----KKLALPTLVLAPLELLT-ASAT-PSP 1801
              .|..|.        |.|.| :::|..:..:.:|    ..|.|.|..:...|..| .||| |:|
Human   486 FCGWTQGT--------LSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAP 542

  Fly  1802 PRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWE--AHERRLETAGTH 1864
            .::      ||.||.:|||....||..   .:|...:...|:. |.|..|.  |:|         
Human   543 IKS------SPCELRMSWLIRGVLRGN---VSLVLVENKTGKE-QGRMVWHVAAYE--------- 588

  Fly  1865 RLTGIKPGSGYSLW--------------------------------------------------V 1879
                     |.|||                                                  :
Human   589 ---------GLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKI 644

  Fly  1880 QAHATPTKSNSSERLHVRSFAELPELQLLELGP-----YSLSLTW----AGTPDPLGSLQLECRS 1935
            ..:..|...|..||...:      ||:..|..|     :..::.|    .|...|.|..|.:|  
Human   645 LQNTAPKSRNLFERNPNK------ELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQC-- 701

  Fly  1936 SAEQLRRNVAGNHTKMVVE-----PLQ-------PRT-RYQCRLLLGYAATPG------APLYHG 1981
                   |.|..::.:.||     ||:       |.| .|.   :.||.|..|      ....||
Human   702 -------NNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYS---ISGYGAAGGKGGKNTMMRSHG 756

  Fly  1982 TA-----------EVYETLGDAPSQ--PGKPQL--------EHIAEEVFRVT-----WTAARG-- 2018
            .:           .:|..:|.....  |...||        .::.||..||.     |....|  
Human   757 VSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGG 821

  Fly  2019 ----------NGAPIALY-----NLEALQARSDIRRRRRRRRRNS-------------GGSLE-- 2053
                      :|.|:.|.     ...|..|::|.....|....:|             ||...  
Human   822 GGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDN 886

  Fly  2054 -QLPWA-----------------------------------------------------EEPVVV 2064
             .|.||                                                     .:|.:.
Human   887 TSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMD 951

  Fly  2065 EDQWLDFCN------TTELS------------------CIVKSLH----SSRLLLFRVRARSLEH 2101
            .:..:.|.:      |..|.                  |.|...|    |.:::.|      .:|
Human   952 GEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICF------CDH 1010

  Fly  2102 GWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRP 2166
            |.....:....:..|...|....||:|:::. :|:|::.|||...:..|.:|:.:..:.:|....
Human  1011 GTVLAEDGVSCIVSPTPEPHLPLSLILSVVT-SALVAALVLAFSGIMIVYRRKHQELQAMQMELQ 1074

  Fly  2167 SIWSNLSTLQTQQQLMAVRNRAF---STTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQL 2228
            |....||.|:| ..:|...|..:   ..|.|.:|:..:|:.|   :.|:|.||.||||||||||:
Human  1075 SPEYKLSKLRT-STIMTDYNPNYCFAGKTSSISDLKEVPRKN---ITLIRGLGHGAFGEVYEGQV 1135

  Fly  2229 K-TEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHME 2290
            . ..:...|.:||:|:|.:..||..||  |.||.::|.|.|:|||..:|:...:....:::|.|.
Human  1136 SGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA 1200

  Fly  2291 AGDLLSYLRAARATSTQEPQPT--AGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVT- 2352
            .|||.|:||..|      |:|:  :.|::.:||.:..|:|.||.|||:.||:|||:|.||||:| 
Human  1201 GGDLKSFLRETR------PRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259

  Fly  2353 ESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLC 2417
            ...|     |..||||||:|||||::.||||.|..:|||:||.||:.::|:||:::|.|:||||.
Human  1260 PGPG-----RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLL 1319

  Fly  2418 WEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLH 2482
            |||.:||..||.:::|.|||..|..|||:..|..|...:|.::..||:..|.:||:|        
Human  1320 WEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF-------- 1376

  Fly  2483 AISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPED 2530
              :..|.|.:..:...|.:.:....|:     |..:||..:...||:|
Human  1377 --AIILERIEYCTQDPDVINTALPIEY-----GPLVEEEEKVPVRPKD 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495 23/93 (25%)
FN3 1799..1897 CDD:238020 26/149 (17%)
FN3 1993..2111 CDD:238020 33/246 (13%)
Pkinase_Tyr 2209..2481 CDD:285015 123/277 (44%)
PTKc_c-ros 2213..2483 CDD:270640 122/275 (44%)
ALKNP_004295.2 MAM 266..427 CDD:279023 46/192 (24%)
MAM 266..424 CDD:99706 43/189 (23%)
LDLa 441..467 CDD:197566 8/53 (15%)
MAM 480..636 CDD:279023 37/191 (19%)
MAM 480..631 CDD:99706 37/186 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..674 8/29 (28%)
FXa_inhibition 987..1021 CDD:291342 7/39 (18%)
PTKc_ALK_LTK 1109..1385 CDD:270632 127/299 (42%)
Pkinase_Tyr 1116..1383 CDD:285015 124/287 (43%)
Inhibitor binding 1197..1199 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1463 3/10 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1514..1540
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D27151at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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