DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and FGFR4

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens


Alignment Length:890 Identity:235/890 - (26%)
Similarity:343/890 - (38%) Gaps:259/890 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1785 LVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRR 1849
            |:||.|.:|.  :.|.|| ..|:......|||....|..:.:.:.:...|.....|.....:...
Human     3 LLLALLGVLL--SVPGPP-VLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGG 64

  Fly  1850 EWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYS 1914
            .|.....||..||  |:.|         |            ..||.:.||  |||    :.|.| 
Human    65 HWYKEGSRLAPAG--RVRG---------W------------RGRLEIASF--LPE----DAGRY- 99

  Fly  1915 LSLTWAGTPDPLGSLQL----ECRSSAE----QLRRNVAGNHT----------------KMVVEP 1955
            |.|. .|:...|.:|.|    ...||.:    :..|:.:..|:                |:...|
Human   100 LCLA-RGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVP 163

  Fly  1956 LQPRTRYQCRLLLGYAATPGAPL--------YHGTAEVYETLGDAPSQPGKPQLEH-----IAEE 2007
            .....:::|..    |..|...:        :||...:           |..:|.|     :.|.
Human   164 AGNTVKFRCPA----AGNPTPTIRWLKDGQAFHGENRI-----------GGIRLRHQHWSLVMES 213

  Fly  2008 VF---RVTWTAARGNGAPIALYN--LEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVED- 2066
            |.   |.|:|....|......||  |:.|:      |...|....:|     ||.....||..| 
Human   214 VVPSDRGTYTCLVENAVGSIRYNYLLDVLE------RSPHRPILQAG-----LPANTTAVVGSDV 267

  Fly  2067 --------------QWLD--FCNTTELSC-------IVKS--LHSSRLLLFRVRARSLEHGWGPY 2106
                          |||.  ..|.:....       ::|:  ::||.:.:..:|..|.|.. |.|
Human   268 ELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDA-GEY 331

  Fly  2107 S---------------------EESERVAEPFVSPEKR---------GSLVLAII---------- 2131
            :                     |:....|   .:||.|         |||.||::          
Human   332 TCLAGNSIGLSYQSAWLTVLPEEDPTWTA---AAPEARYTDIILYASGSLALAVLLLLAGLYRGQ 393

  Fly  2132 -------APAAIV-----------------SSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNL 2172
                   .|.|.|                 ||...:..|||.|:         |..|.|::.:.|
Human   394 ALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVR---------LSSSGPALLAGL 449

  Fly  2173 STLQTQQQLMAVRNRAFSTTLSDADIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLKTEDS 2233
            .:|                     |:.|.|.  |    .:|.|.:.||.|.||:|...:....|.
Human   450 VSL---------------------DLPLDPL--WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDP 491

  Fly  2234 EEPQR---VAIKSLRKGAS--EFAELLQEAQLMSNF-KHENIVCLVGICFDTESISLIMEHMEAG 2292
            ..|.:   ||:|.|:..||  :.|:|:.|.::|... :|:||:.|:|:|.....:.:|:|....|
Human   492 ARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 556

  Fly  2293 DLLSYLRAARA----TSTQEPQPTAG-LSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVT 2352
            :|..:|||.|.    .|...|:.:.| ||...|::....||.|..|||....:|||||.||.|||
Human   557 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVT 621

  Fly  2353 ESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLC 2417
            |.       ..:||.||||||.::..|||:|...|.|||:||:||:|.|.::|.|||||:||:|.
Human   622 ED-------NVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILL 679

  Fly  2418 WEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLH 2482
            |||.|||..||......|:.:.::||.|:.:||.|..:||.|:..||...|.:||:|::....|.
Human   680 WEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744

  Fly  2483 ----AIS---TDLRRT--QMASATADTVVSCSRPEFKVRFDGQPL 2518
                |:|   .|||.|  ..:.:..|...:||..:.....|..||
Human   745 KVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPL 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 17/90 (19%)
FN3 1993..2111 CDD:238020 34/174 (20%)
PTKc_c-ros 2213..2483 CDD:270640 111/284 (39%)
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046 22/98 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148 4/28 (14%)
IgI_2_FGFR 147..241 CDD:409443 19/108 (18%)
Ig strand A 147..150 CDD:409443 0/2 (0%)
Ig strand A' 158..163 CDD:409443 1/4 (25%)
Ig strand B 167..175 CDD:409443 1/11 (9%)
Ig strand C 181..186 CDD:409443 0/4 (0%)
Ig strand C' 189..191 CDD:409443 0/1 (0%)
Ig strand D 200..203 CDD:409443 0/2 (0%)
Ig strand E 207..212 CDD:409443 0/4 (0%)
Ig strand F 221..228 CDD:409443 2/6 (33%)
Ig strand G 231..241 CDD:409443 3/9 (33%)
Ig 249..351 CDD:472250 18/107 (17%)
Ig strand B 267..271 CDD:409444 0/3 (0%)
Ig strand C 280..284 CDD:409444 1/3 (33%)
Ig strand E 316..320 CDD:409444 0/3 (0%)
Ig strand F 330..335 CDD:409444 1/4 (25%)
Ig strand G 343..346 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 454..767 CDD:473864 122/321 (38%)
Blue background indicates that the domain is not in the aligned region.

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