DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and FGFR3

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_006713931.1 Gene:FGFR3 / 2261 HGNCID:3690 Length:811 Species:Homo sapiens


Alignment Length:891 Identity:224/891 - (25%)
Similarity:359/891 - (40%) Gaps:257/891 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1717 IPGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESLNL-------------------TDLLP 1762
            :||          .|||.:|         |.:.|:|:::.|                   |.|:|
Human    38 VPG----------PEPGQQE---------QLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVP 83

  Fly  1763 FTRYRVSGILSSFYQKKLALPTLVLAP--LELLTASATPSPPR------------NFSVRVL-SP 1812
            ..|                   :::.|  |::|.||...|...            :|||||. :|
Human    84 SER-------------------VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAP 129

  Fly  1813 R---------ELEVS--------WLPPEQLRSESVYY----TLHWQQELDGENVQDRREWEAHER 1856
            .         |.|.:        |..||::..:.:..    |:.::....| |......|..:.|
Human   130 SSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG-NPTPSISWLKNGR 193

  Fly  1857 RLETAGTHRLTGIKPGSGYSLW--VQAHATPTKSNSSERLHVRSFAELPE---LQLLELGPYSLS 1916
              |..|.||:.|||  ..:..|  |.....|:...:...:....|..:.:   |.:||..|:. .
Human   194 --EFRGEHRIGGIK--LRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHR-P 253

  Fly  1917 LTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHG 1981
            :..||.|                      .|.|.::...::    :.|:                
Human   254 ILQAGLP----------------------ANQTAVLGSDVE----FHCK---------------- 276

  Fly  1982 TAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAP----IALYNLEALQARSDIRRRRR 2042
               ||     :.:||....|:|:     .|..:....:|.|    :..:..|:::|  |:|.|..
Human   277 ---VY-----SDAQPHIQWLKHV-----EVNGSKVGPDGTPYVTVLKSWISESVEA--DVRLRLA 326

  Fly  2043 RRRRNSGGSLEQLPWAEEPVVVEDQ--WLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGP 2105
            ......||  |.|..|...:.|.::  ||             |:|                  ||
Human   327 NVSERDGG--EYLCRATNFIGVAEKAFWL-------------SVH------------------GP 358

  Fly  2106 YSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRA--KK--------- 2159
            .:.|.|     .|..::.||:...|::...   ...|.:::|..|...|||:  ||         
Human   359 RAAEEE-----LVEADEAGSVYAGILSYGV---GFFLFILVVAAVTLCRLRSPPKKGLGSPTVHK 415

  Fly  2160 -----LLQQSRPSIWSNLS-TLQTQQQLMAVRNRAFSTTLSDADIALLP-----QINWSQLKLLR 2213
                 |.:|...|:.||.| :..|....:|..:.....||::.....||     :::.::|.|.:
Human   416 ISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGK 480

  Fly  2214 FLGSGAFGEVYEGQ---LKTEDSEEPQRVAIKSLRKGAS--EFAELLQEAQLMSNF-KHENIVCL 2272
            .||.|.||:|...:   :..:.:.:|..||:|.|:..|:  :.::|:.|.::|... ||:||:.|
Human   481 PLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINL 545

  Fly  2273 VGICFDTESISLIMEHMEAGDLLSYLRAAR------ATSTQEPQPTAGLSLSELLAMCIDVANGC 2331
            :|.|.....:.:::|:...|:|..:|||.|      :..|.:| |...|:..:|::....||.|.
Human   546 LGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKP-PEEQLTFKDLVSCAYQVARGM 609

  Fly  2332 SYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSP 2396
            .||.....:|||||.||.||||.       ..:||.|||||||::..|||:|...|.|||:||:|
Human   610 EYLASQKCIHRDLAARNVLVTED-------NVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAP 667

  Fly  2397 ESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLL 2461
            |:|.|.::|.|||||:||||.|||.|||..||......|:...:|||.|:.:|..||..||.::.
Human   668 EALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMR 732

  Fly  2462 LCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRP 2507
            .||...|.:||:|::       :..||.|....::|....:..|.|
Human   733 ECWHAAPSQRPTFKQ-------LVEDLDRVLTVTSTDQEYLDLSAP 771

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 27/126 (21%)
FN3 1993..2111 CDD:238020 25/123 (20%)
PTKc_c-ros 2213..2483 CDD:270640 107/281 (38%)
FGFR3XP_006713931.1 Ig 37..109 CDD:472250 20/108 (19%)
Ig strand B 57..61 CDD:409362 1/3 (33%)
Ig strand C 69..75 CDD:409362 0/5 (0%)
Ig strand E 92..96 CDD:409362 1/3 (33%)
IgI_2_FGFR 151..245 CDD:409443 20/98 (20%)
Ig strand A 151..154 CDD:409443 0/2 (0%)
Ig strand A' 162..167 CDD:409443 0/4 (0%)
Ig strand B 171..179 CDD:409443 1/7 (14%)
Ig strand C 185..190 CDD:409443 1/4 (25%)
Ig strand C' 193..195 CDD:409443 1/3 (33%)
Ig strand D 204..207 CDD:409443 2/4 (50%)
Ig strand E 211..216 CDD:409443 2/4 (50%)
Ig strand F 225..232 CDD:409443 0/6 (0%)
Ig strand G 235..245 CDD:409443 1/9 (11%)
IgI_3_FGFR 253..354 CDD:409363 28/172 (16%)
Ig strand A 253..256 CDD:409363 0/2 (0%)
Ig strand A' 260..264 CDD:409363 2/25 (8%)
Ig strand B 272..279 CDD:409363 3/34 (9%)
Ig strand C 283..290 CDD:409363 2/6 (33%)
Ig strand D 305..310 CDD:409363 0/4 (0%)
Ig strand E 321..326 CDD:409363 2/4 (50%)
Ig strand F 334..342 CDD:409363 4/9 (44%)
Ig strand G 345..353 CDD:409363 1/7 (14%)
Protein Kinases, catalytic domain 463..797 CDD:473864 117/324 (36%)
Blue background indicates that the domain is not in the aligned region.

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