DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and FGFR1

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_001167538.1 Gene:FGFR1 / 2260 HGNCID:3688 Length:853 Species:Homo sapiens


Alignment Length:1041 Identity:245/1041 - (23%)
Similarity:385/1041 - (36%) Gaps:332/1041 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1649 RQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCE----EQRCLLHLPMITA 1709
            ::::|.|||.                 |..|       |:|...::|.    ..:|||...::..
Human     8 KRRIELTVEY-----------------PWRC-------GALSPTSNCRTGMWSWKCLLFWAVLVT 48

  Fly  1710 SEDC---PLPI--------------------PGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLG- 1750
            :..|   |.|.                    ||...||...|..:..|.          .||.. 
Human    49 ATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSI----------NWLRDG 103

  Fly  1751 -----------AGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRN 1804
                       .||.:.:.|.:|..    ||:.:                  .:|:|.:.|....
Human   104 VQLAESNRTRITGEEVEVQDSVPAD----SGLYA------------------CVTSSPSGSDTTY 146

  Fly  1805 FSVRV-------------------------LSPRELEVSWLPPEQLR--------SESVYY---- 1832
            |||.|                         ..|..:...|..||::.        :::|.:    
Human   147 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 211

  Fly  1833 ------TLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLW--VQAHATPTKSN 1889
                  ||.|        :::.:|::.         .||:.|.|  ..|:.|  :.....|:...
Human   212 SGTPNPTLRW--------LKNGKEFKP---------DHRIGGYK--VRYATWSIIMDSVVPSDKG 257

  Fly  1890 SSERLHVRSFAELP---ELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKM 1951
            :...:....:..:.   :|.::|..|:. .:..||.|                ..:.||      
Human   258 NYTCIVENEYGSINHTYQLDVVERSPHR-PILQAGLP----------------ANKTVA------ 299

  Fly  1952 VVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAA 2016
                |.....:.|:                   ||     :..||....|:||  ||        
Human   300 ----LGSNVEFMCK-------------------VY-----SDPQPHIQWLKHI--EV-------- 326

  Fly  2017 RGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIV 2081
              ||:.|...||..:|.           .:.:|.:...    :|..|:..:.:.|.:..|.:|:.
Human   327 --NGSKIGPDNLPYVQI-----------LKTAGVNTTD----KEMEVLHLRNVSFEDAGEYTCLA 374

  Fly  2082 KSLHSSRLLLFRVRARSLEH--GWGPYSEESERVAEPFVSPEKRGSLVLAII--APAAIVSSCVL 2142
            .:            :..|.|  .|....|..|.......||     |.|.||  ...|.:.||::
Human   375 GN------------SIGLSHHSAWLTVLEALEERPAVMTSP-----LYLEIIIYCTGAFLISCMV 422

  Fly  2143 ALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFS----------TTLSDAD 2197
            ..|:|.|::.   ..||....|:.::.....::..::|:....:.:.|          :.||.:.
Human   423 GSVIVYKMKS---GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSG 484

  Fly  2198 IALLPQIN---------W----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQR---VAIKSLRK 2246
            ..:|..::         |    .:|.|.:.||.|.||:|...:....|.::|.|   ||:|.|:.
Human   485 TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS 549

  Fly  2247 GASE--FAELLQEAQLMSNF-KHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQ- 2307
            .|:|  .::|:.|.::|... ||:||:.|:|.|.....:.:|:|:...|:|..||:|.|....: 
Human   550 DATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY 614

  Fly  2308 ----EPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGD 2368
                ...|...||..:|::....||.|..||.....:|||||.||.||||.       ..:||.|
Human   615 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED-------NVMKIAD 672

  Fly  2369 FGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNN 2433
            |||||||:..|||:|...|.|||:||:||:|.|.::|.|||||:||||.|||.|||..||.....
Human   673 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV 737

  Fly  2434 FEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI----------STDL 2488
            .|:...:|||.|:.:|..||.:||.::..||...|.:||:|::....|..|          ...:
Human   738 EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 802

  Fly  2489 RRTQMASATADTVVS-CSRPEFKVRFDGQPLEEHREHNERPEDENLTLREVPLKDKQLYANEGVS 2552
            ...|.:.:..||..| ||..|..| |..:||         ||:..|     |....|| ||.|:.
Human   803 PLDQYSPSFPDTRSSTCSSGEDSV-FSHEPL---------PEEPCL-----PRHPAQL-ANGGLK 851

  Fly  2553 R 2553
            |
Human   852 R 852

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 21/135 (16%)
FN3 1993..2111 CDD:238020 23/119 (19%)
PTKc_c-ros 2213..2483 CDD:270640 112/280 (40%)
FGFR1NP_001167538.1 IgI_1_FGFR 58..151 CDD:409362 21/124 (17%)
Ig strand A 58..61 CDD:409362 1/2 (50%)
Ig strand A' 73..79 CDD:409362 0/5 (0%)
Ig strand B 82..92 CDD:409362 3/9 (33%)
Ig strand C 96..101 CDD:409362 2/14 (14%)
Ig strand C' 104..106 CDD:409362 0/1 (0%)
Ig strand D 111..115 CDD:409362 0/3 (0%)
Ig strand E 118..123 CDD:409362 0/4 (0%)
Ig strand F 129..138 CDD:409362 3/26 (12%)
Ig strand G 141..151 CDD:409362 4/9 (44%)
IgI_2_FGFR 184..278 CDD:409443 16/112 (14%)
Ig strand A 184..187 CDD:409443 0/2 (0%)
Ig strand A' 195..200 CDD:409443 0/4 (0%)
Ig strand B 204..212 CDD:409443 1/7 (14%)
Ig strand C 218..223 CDD:409443 3/12 (25%)
Ig strand C' 226..228 CDD:409443 0/1 (0%)
Ig strand D 237..240 CDD:409443 1/4 (25%)
Ig strand E 244..249 CDD:409443 1/4 (25%)
Ig strand F 258..265 CDD:409443 0/6 (0%)
Ig strand G 268..278 CDD:409443 1/9 (11%)
Ig 286..390 CDD:472250 31/192 (16%)
Ig strand B 304..308 CDD:409353 0/3 (0%)
Ig strand C 317..321 CDD:409353 0/3 (0%)
Ig strand E 355..359 CDD:409353 1/3 (33%)
Ig strand F 369..374 CDD:409353 2/4 (50%)
Ig strand G 382..385 CDD:409353 1/2 (50%)
PTKc_FGFR1 495..796 CDD:270678 116/307 (38%)
Blue background indicates that the domain is not in the aligned region.

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