Protein Alignment sev and Ros1

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_011241449.1
• Gene: Ros1 / 19886
• MGIID: 97999
• Length: 2341
• Species: Mus musculus
• Alignment Length: 2582
• Identity: 669/2582 - (25%)
• Similarity: 1028/2582 - (39%)
• Gaps: 589/2582 - (22%)

  Fly   216 VTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKC-YKTRCTKGCAQW---------------YRAL 264
            |...|:..|:.       ..|.|   .|:|.:. ....|..||..|               |..:
Mouse    30 VLSSCLTSCVT-------NLGRQ---LDSGTRYNLSEACIHGCQFWNSVDQETCALKCNDTYATI 84

  Fly   265 KELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADG-QSTP 328
            .|.|||:..|.:.:         |:.|              ..::|.|  :|..||.|.. .|..
Mouse    85 CERESCEVGCSNAE---------GSYE--------------EEVLEST--ELPTAPFASSIGSHG 124

  Fly   329 LTIRWAMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASG-----ETGSSAWFNLADYDCD 388
            :|:||           .|.||.       |.:..::.:.....|     ||.|...:.
Mouse   125 VTLRW-----------NPANIS-------GVKYIIQWKYAQLPGSWTFTETVSKLSYT------- 164

  Fly   389 EYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSH 453
                   :|.|.|:|:|.||....|.....  ||||.:|:|:|.|.|.|.:||:|.::.......
Mouse   165 -------VEPLHPFTEYIFRVVWIFTAQLH--LYSPPSPSYRTHPYGVPETAPLILNMESWSPDT 220

  Fly   454 LAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAG--RGSYIFSQLQAGTNYTLALSMINKQ 516
            :.|.|.|..|..|||.||.|||.|      ..|.:.:|  |.|:.|......|.|..:::.:|:.
Mouse   221 VEVSWAPPHFPGGPILGYNLRLIS------KNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEV 279

  Fly   517 GEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKR 581
            ||||.|:..|.|.|     |:....|..|.:.|:.    ||.   :.|:.|...|  |...||..
Mouse   280 GEGPEAESTVTTPS-----PSVQEEEQWLFLSRKT----SLR---KRSLKYLVDE--AHCLWSDA 330

  Fly   582 -EQQLWLLNVHGELRSLKFESGQMV--------SPAQQLKL---DLGNISSGRWVPRRLSFDWLH 634
             ...:..::|:.:.:.:.|..|.::        |....|::   ..|.:||       :|.|||:
Mouse   331 IHHNITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSS-------ISIDWLY 388

  Fly   635 HRLYFAMES-----PERNQSSFQIISTDLLGESTQKVGESFDLPVEQLEVDALNGWIFWRNEESL 694
            .|:||.|:.     ..:|.|:.:.|:...|            :..:::.||:.||::|:...:.:
Mouse   389 QRMYFIMDKLVYVCELKNCSNLEEITPFSL------------IAPQKVVVDSYNGYLFYLLRDGI 441

  Fly   695 WRQDL---HGRMIHRLLRIRQPGW---FLVQPQHFIIHLMLPQEGKFLEISYDGGFKHPLPLPPP 753
            :|.:|   .||.. :.:||.:.|.   |.|:||...|.........|:....||...|.: ||
Mouse   442 YRVNLPLPSGRDT-KAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRV-LP-- 502

  Fly   754 SNGAGNGPASSHW------QSFALLGRSLLLPDSGQLILVEQQ--------GQAASPSASWPLKN 804
                        |      :|||......|:.| |:.|..:..        |...|....:...|
Mouse   503 ------------WVPLVTVKSFACENNDFLITD-GKAIFQQDSLSFNEFIVGCDLSHIEEFGFGN 554

  Fly   805 LPDCWAVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLD 869
            |    .:.....:|.||.   |.|..:..|.|::.|.|.|..|......|..|.::|:||::|.
Mouse   555 L----VIFGSSVQSYPLP---GHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVY- 611

  Fly   870 VASQSAFSI----RNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLR 930
              ||....|    .||.|.:..:..||....|.:.|||.:..| ||.|:.|....|
Mouse   612 --SQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKG-PGPWSAPSVGTT--------- 664

  Fly   931 WASRQGSVIHTNELGEGLEVQQEQLERLP----GPMTMVNESVG------------YYVTGDGLL 979
                   ::...|....:.|:::.|...|    ||...::..||            ||....|.:
Mouse   665 -------LVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNV 722

  Fly   980 HCINLVHSQWGCPISEPLQHV------GSVTYDWRGGRVYWTDLARNCVV-RMDPWSGSRELLPV 1037
            :    |....|..|||. .|:      |::.::|.|..:||.  .:..|: |....:|..:::..
Mouse   723 Y----VRPLNGMDISEN-YHIPSIVGAGALAFEWLGHFLYWA--GKTYVIQRQSVLTGHTDIVTH 780

  Fly  1038 FE--ANFLALDPRQGHLYYAT-----SSQLSRHGSTPDEAVTYYRVNGLEG-SIASFVLDTQQDQ 1094
            .:  .|.:|:|...|:||:.|     |::|:...|...:|..:     |.| .:.:..||.....
Mouse   781 VKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPW-----LSGKKVIALTLDLSDGL 840

  Fly  1095 LFWLVKGSGALRLYRAPLT--AGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARL 1157
            |:|||:.:..:.||.|.|.  :|||:  .|.:......:......|:...|.|.|:..
Mouse   841 LYWLVQDNQCIHLYTAVLRGWSGGDA--TITEFAAWSTSEISQNALMYYSGRLFWING------- 896

  Fly  1158 VRLAAPLDVMELPTPDQASPASALQLLDPQ----PLP------PRDEGVIPMTVLPDSVRLDDGH 1212
            .|:....::.:..:...:.||...|....|    |||      |:   |||..|...|.|: :||
Mouse   897 FRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPK---VIPDPVQESSFRI-EGH 957

  Fly  1213 WDDFHVRWQ--PSTSGGNHSVSYRLLLEFGQRLQTLDL---STPFARLTQLPQAQLQLKISITPR 1272
            ...|.:.|.  |:...|  .|.|.  :||....:.|.:   |.|...:..|....| ..:|:||.
Mouse   958 TSSFQILWNEPPAVDWG--IVFYS--VEFSTHSKFLIIEQQSLPIFTVEGLEPYTL-FNLSVTPY 1017

  Fly  1273 TAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAP--EQGQEAPMQALE 1335
            |.|..|..|.:....|...||.|...|:|:.......::..|....||:.|  |.|.....: :.
Mouse  1018 TYWGKGQKTSLSFRAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFE-IF 1081

  Fly  1336 YHISCWVGSELHEELRLNQS----ALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAP 1396
            ||||...|:....|..::.|    .:..::|.:.|:.|..|||  ||..:......:...:....
Mouse  1082 YHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQV--RVFTSKGPGPFSDIVMSKTS 1144

  Fly  1397 EVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVEL-------- 1453
            |::..|.::......|..||:|   :.:::.|.|       :||:...:......|:
Mouse  1145 EIKPCPYLISLLGNKIVFLDMD---QNQVLWTFS-------LEGDVSTVGYTTDDEMGYFAQGDT 1199

  Fly  1454 --LTHVPGSAPAKLAR--MRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQG 1514
              |.::...:.:||.:  :.:::..:|||||.|.:|:| |.| :.....|:.:||   |.|:...
Mouse  1200 LFLLNLRNHSSSKLFQDALVSDIRVIAVDWIARHLYFA-LKA-SQNGTQIFNVDL---EHKVKSP 1259

  Fly  1515 ERVWSTPRGRLLKDLVALPQAQSLIWLEY-EQG-----------------SPRNGSLRGR----- 1556
            ..|.:......:......|....|.|.|. :.|                 .|:..:..||
Mouse  1260 REVKTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRSQCSC 1324

  Fly  1557 NLTDGSELEWATVQPLIRLHAGSLEPG--------SETLNLVDNQGKLCVYDVARQLCTASALRA 1613
            |:|: |||..|       :...:.:|.        .:.:..:|.:|..|...:......|.....
Mouse  1325 NVTE-SELSGA-------MTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPAGKRII 1381

  Fly  1614 QLNLLGEDSIAGQLAQDSGYLYAVKNWS------IRAYGRRRQQLEYTVELEPEEVRLLQAHNYQ 1672
            .|.:.||........:|...:|..|..|      ::| .|.:..|.|:..|:|
Mouse  1382 SLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKA-SRSKHILAYSSALQP------------ 1433

  Fly  1673 AYPPKNCLLLPSS--GGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTL-----AK 1730
             :|.|..|.|.|.  ..::|.||:..   ..|.||.:..:    |...|:.:..:..|     |.
Mouse  1434 -FPDKAYLSLASDMVEATILYATNTS---LTLKLPPVKTN----LTWHGITHPTSTYLIYYMEAN 1490

  Fly  1731 EPGSEEHDHGMEPLGQWLLGAGESL-NLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELL- 1793
            ...|.:..|.|       |.:.|:: .:..|.||:.|.:...:.::|.:          |||.|
Mouse  1491 RANSSDRRHKM-------LESQENVARIEGLQPFSMYMIQIAVKNYYSE----------PLEHLP 1538

  Fly  1794 --------TASATPSPPRNFSVRVLSPRELEVSWL-------PPEQLRSESVYYTLHWQQELDGE 1843
                    |.|..|....:.:..|||...|.|.|.       |.|.:|.:.|...|....|
Mouse  1539 LGKEIQGQTKSGVPGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPE---- 1599

  Fly  1844 NVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQA-HATPTKSNSSERLHVRSF--AELPEL 1905
              ...|:.|....:|...    :|.:..|..|.:.|.| |........|..:.|..|  .|.|..
Mouse  1600 --TPLRQGEFPSAKLSLL----ITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSA 1658

  Fly  1906 QLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAG-------------NHTKMV----- 1952
            .:.|  ..||.|.|            :.||:.     |:.|             .|.|..
Mouse  1659 LVPE--NTSLQLDW------------KARSNV-----NLTGFWFELQKWKYNEFYHVKASCSQGP 1704

  Fly  1953 -----VEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVT 2012
                 :..|||.|.|..|:::.|.....:   ....|.::|....||:||.|:|...::.  .:.
Mouse  1705 VYVCNITDLQPYTSYNIRVVVVYTTGENS---SSIPESFKTKAGVPSKPGIPKLLEGSKN--SIQ 1764

  Fly  2013 WTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQW-LDFCNTTE 2076
            |..|..||:.:..|.||.             |:..|..|..|          ..:| :.|..:..
Mouse  1765 WEKAEDNGSRLMYYTLEV-------------RKGISNDSQNQ----------SSRWKVVFNGSCS 1806

  Fly  2077 LSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERV--AEPFVSPEKRGSLVLAIIAPAAIVSS 2139
            ..|..:|.:......||..|.: |.|.|.|||.||.:  .|..|...:. |.:|.||....:|::
Mouse  1807 SICTWRSKNLKGTFQFRAVAAN-EIGLGEYSEISEDITLVEDGVWITET-SFILTIIVGIFLVAT 1869

  Fly  2140 CVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTL-QTQQQLMAVRNRAFSTTLSDA------- 2196
            ..|..|..|.::..  :|.|          ..||.| ...::|..:|..|....|::|
Mouse  1870 VPLTFVWHRSLKSH--KASK----------EGLSVLNDNDKELAELRGLAAGVGLANACYAVHTV 1922

  Fly  2197 ----DIALLPQINWSQLKLLRFLGSGAFGEVYEGQ----LKTEDSEEPQRVAIKSLRKGAS--EF 2251
                :|..||.....:|.|...||||||||||||.    |.....|  .:||:|:|:||::  |.
Mouse  1923 PTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAIDILGVGSGE--IKVAVKTLKKGSTDQEK 1985

  Fly  2252 AELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLS 2316
            .|.|:||.|||.|.|.||:..:|:|...|...:|:|.||.||||||||.||.|:...|    .|:
Mouse  1986 IEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGP----SLT 2046

  Fly  2317 LSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY 2381
            |.:|:.:|:|::.||.|||.|||:|||||.|||||  |.......|.||||||||||:|||:|||
Mouse  2047 LLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLV--SVKDYTSPRVVKIGDFGLAREIYKNDYY 2109

  Fly  2382 RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRL 2446
            ||.||||||||||:||:|:||:||:|||||:||:|.|||||||.|||.|.:|.:||.:|:.||||
Mouse  2110 RKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRL 2174

  Fly  2447 QQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI-STDLRRTQMASATADT--VVSCSRPE 2508
            :.|..|.:.|::|:..||..:|.:||:|....|.|... :..|.........|.|  |::..
Mouse  2175 EPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNVSHCGEAAPTGGVINKG--- 2236

  Fly  2509 FKVRFDGQPLEEHREHNERPEDENLTLRE---VPLKDKQLYANEGVS 2552
                |:|:            :||.:||..   :|:...:....||::
Mouse  2237 ----FEGE------------DDEMVTLNSDDTMPVALMETKNQEGLN 2267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996	26/82 (32%)
		FN3	826..921	CDD:238020	31/98 (32%)
		Vgb	992..>1118	CDD:443399	37/142 (26%)
		LY	993..1026	CDD:214531	11/39 (28%)
		FN3	1292..1374	CDD:214495	22/87 (25%)
		fn3	1800..1891	CDD:394996	21/98 (21%)
		FN3	1993..2111	CDD:238020	30/118 (25%)
		PTKc_c-ros	2213..2483	CDD:270640	150/275 (55%)
Ros1	XP_011241449.1	FN3	<100..>296	CDD:442628	70/256 (27%)
		FN3	568..664	CDD:238020	31/102 (30%)
		FN3	1037..1143	CDD:238020	26/108 (24%)
		FN3	<1502..>1753	CDD:442628	64/292 (22%)
		FN3	1651..1742	CDD:238020	21/112 (19%)
		FN3	1747..1840	CDD:238020	30/118 (25%)
		PTKc_c-ros	1949..2210	CDD:270640	145/268 (54%)