DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and Ros1

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_011241449.1 Gene:Ros1 / 19886 MGIID:97999 Length:2341 Species:Mus musculus


Alignment Length:2582 Identity:669/2582 - (25%)
Similarity:1028/2582 - (39%) Gaps:589/2582 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   216 VTRDCVQRCIVEEDLFLDEFGIQCEKADNGEKC-YKTRCTKGCAQW---------------YRAL 264
            |...|:..|:.       ..|.|   .|:|.:. ....|..||..|               |..:
Mouse    30 VLSSCLTSCVT-------NLGRQ---LDSGTRYNLSEACIHGCQFWNSVDQETCALKCNDTYATI 84

  Fly   265 KELESCQEACLSLQFYPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADG-QSTP 328
            .|.|||:..|.:.:         |:.|              ..::|.|  :|..||.|.. .|..
Mouse    85 CERESCEVGCSNAE---------GSYE--------------EEVLEST--ELPTAPFASSIGSHG 124

  Fly   329 LTIRWAMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASG-----ETGSSAWFNLADYDCD 388
            :|:||           .|.||.       |.:..::.:.....|     ||.|...:.       
Mouse   125 VTLRW-----------NPANIS-------GVKYIIQWKYAQLPGSWTFTETVSKLSYT------- 164

  Fly   389 EYYVCEILEALIPYTQYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEHLMGLDDSH 453
                   :|.|.|:|:|.||....|.....  ||||.:|:|:|.|.|.|.:||:|.::.......
Mouse   165 -------VEPLHPFTEYIFRVVWIFTAQLH--LYSPPSPSYRTHPYGVPETAPLILNMESWSPDT 220

  Fly   454 LAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAG--RGSYIFSQLQAGTNYTLALSMINKQ 516
            :.|.|.|..|..|||.||.|||.|      ..|.:.:|  |.|:.|......|.|..:::.:|:.
Mouse   221 VEVSWAPPHFPGGPILGYNLRLIS------KNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEV 279

  Fly   517 GEGPVAKGFVQTHSARNEKPAKDLTESVLLVGRRAVMWQSLEPAGENSMIYQSQEELADIAWSKR 581
            ||||.|:..|.|.|     |:....|..|.:.|:.    ||.   :.|:.|...|  |...||..
Mouse   280 GEGPEAESTVTTPS-----PSVQEEEQWLFLSRKT----SLR---KRSLKYLVDE--AHCLWSDA 330

  Fly   582 -EQQLWLLNVHGELRSLKFESGQMV--------SPAQQLKL---DLGNISSGRWVPRRLSFDWLH 634
             ...:..::|:.:.:.:.|..|.::        |....|::   ..|.:||       :|.|||:
Mouse   331 IHHNITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSS-------ISIDWLY 388

  Fly   635 HRLYFAMES-----PERNQSSFQIISTDLLGESTQKVGESFDLPVEQLEVDALNGWIFWRNEESL 694
            .|:||.|:.     ..:|.|:.:.|:...|            :..:::.||:.||::|:...:.:
Mouse   389 QRMYFIMDKLVYVCELKNCSNLEEITPFSL------------IAPQKVVVDSYNGYLFYLLRDGI 441

  Fly   695 WRQDL---HGRMIHRLLRIRQPGW---FLVQPQHFIIHLMLPQEGKFLEISYDGGFKHPLPLPPP 753
            :|.:|   .||.. :.:||.:.|.   |.|:||...|.........|:....||...|.: ||  
Mouse   442 YRVNLPLPSGRDT-KAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRV-LP-- 502

  Fly   754 SNGAGNGPASSHW------QSFALLGRSLLLPDSGQLILVEQQ--------GQAASPSASWPLKN 804
                        |      :|||......|:.| |:.|..:..        |...|....:...|
Mouse   503 ------------WVPLVTVKSFACENNDFLITD-GKAIFQQDSLSFNEFIVGCDLSHIEEFGFGN 554

  Fly   805 LPDCWAVILLVPESQPLTSAGGKPHSLKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLD 869
            |    .:.....:|.||.   |.|..:..|.|::.|.|.|..|......|..|.::|:||::|. 
Mouse   555 L----VIFGSSVQSYPLP---GHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVY- 611

  Fly   870 VASQSAFSI----RNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGPHRLR 930
              ||....|    .||.|.:..:..||....|.:.|||.:..| ||.|:.|....|         
Mouse   612 --SQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKG-PGPWSAPSVGTT--------- 664

  Fly   931 WASRQGSVIHTNELGEGLEVQQEQLERLP----GPMTMVNESVG------------YYVTGDGLL 979
                   ::...|....:.|:::.|...|    ||...::..||            ||....|.:
Mouse   665 -------LVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNV 722

  Fly   980 HCINLVHSQWGCPISEPLQHV------GSVTYDWRGGRVYWTDLARNCVV-RMDPWSGSRELLPV 1037
            :    |....|..|||. .|:      |::.::|.|..:||.  .:..|: |....:|..:::..
Mouse   723 Y----VRPLNGMDISEN-YHIPSIVGAGALAFEWLGHFLYWA--GKTYVIQRQSVLTGHTDIVTH 780

  Fly  1038 FE--ANFLALDPRQGHLYYAT-----SSQLSRHGSTPDEAVTYYRVNGLEG-SIASFVLDTQQDQ 1094
            .:  .|.:|:|...|:||:.|     |::|:...|...:|..:     |.| .:.:..||.....
Mouse   781 VKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPW-----LSGKKVIALTLDLSDGL 840

  Fly  1095 LFWLVKGSGALRLYRAPLT--AGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARL 1157
            |:|||:.:..:.||.|.|.  :|||:  .|.:......:......|:...|.|.|:..       
Mouse   841 LYWLVQDNQCIHLYTAVLRGWSGGDA--TITEFAAWSTSEISQNALMYYSGRLFWING------- 896

  Fly  1158 VRLAAPLDVMELPTPDQASPASALQLLDPQ----PLP------PRDEGVIPMTVLPDSVRLDDGH 1212
            .|:....::.:..:...:.||...|....|    |||      |:   |||..|...|.|: :||
Mouse   897 FRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPK---VIPDPVQESSFRI-EGH 957

  Fly  1213 WDDFHVRWQ--PSTSGGNHSVSYRLLLEFGQRLQTLDL---STPFARLTQLPQAQLQLKISITPR 1272
            ...|.:.|.  |:...|  .|.|.  :||....:.|.:   |.|...:..|....| ..:|:||.
Mouse   958 TSSFQILWNEPPAVDWG--IVFYS--VEFSTHSKFLIIEQQSLPIFTVEGLEPYTL-FNLSVTPY 1017

  Fly  1273 TAWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAP--EQGQEAPMQALE 1335
            |.|..|..|.:....|...||.|...|:|:.......::..|....||:.|  |.|.....: :.
Mouse  1018 TYWGKGQKTSLSFRAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFE-IF 1081

  Fly  1336 YHISCWVGSELHEELRLNQS----ALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVAP 1396
            ||||...|:....|..::.|    .:..::|.:.|:.|..|||  ||..:......:...:....
Mouse  1082 YHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQV--RVFTSKGPGPFSDIVMSKTS 1144

  Fly  1397 EVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVEL-------- 1453
            |::..|.::......|..||:|   :.:::.|.|       :||:...:......|:        
Mouse  1145 EIKPCPYLISLLGNKIVFLDMD---QNQVLWTFS-------LEGDVSTVGYTTDDEMGYFAQGDT 1199

  Fly  1454 --LTHVPGSAPAKLAR--MRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQG 1514
              |.::...:.:||.:  :.:::..:|||||.|.:|:| |.| :.....|:.:||   |.|:...
Mouse  1200 LFLLNLRNHSSSKLFQDALVSDIRVIAVDWIARHLYFA-LKA-SQNGTQIFNVDL---EHKVKSP 1259

  Fly  1515 ERVWSTPRGRLLKDLVALPQAQSLIWLEY-EQG-----------------SPRNGSLRGR----- 1556
            ..|.:......:......|....|.|.|. :.|                 .|:..:..||     
Mouse  1260 REVKTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRSQCSC 1324

  Fly  1557 NLTDGSELEWATVQPLIRLHAGSLEPG--------SETLNLVDNQGKLCVYDVARQLCTASALRA 1613
            |:|: |||..|       :...:.:|.        .:.:..:|.:|..|...:......|.....
Mouse  1325 NVTE-SELSGA-------MTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPAGKRII 1381

  Fly  1614 QLNLLGEDSIAGQLAQDSGYLYAVKNWS------IRAYGRRRQQLEYTVELEPEEVRLLQAHNYQ 1672
            .|.:.||........:|...:|..|..|      ::| .|.:..|.|:..|:|            
Mouse  1382 SLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKA-SRSKHILAYSSALQP------------ 1433

  Fly  1673 AYPPKNCLLLPSS--GGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTL-----AK 1730
             :|.|..|.|.|.  ..::|.||:..   ..|.||.:..:    |...|:.:..:..|     |.
Mouse  1434 -FPDKAYLSLASDMVEATILYATNTS---LTLKLPPVKTN----LTWHGITHPTSTYLIYYMEAN 1490

  Fly  1731 EPGSEEHDHGMEPLGQWLLGAGESL-NLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELL- 1793
            ...|.:..|.|       |.:.|:: .:..|.||:.|.:...:.::|.:          |||.| 
Mouse  1491 RANSSDRRHKM-------LESQENVARIEGLQPFSMYMIQIAVKNYYSE----------PLEHLP 1538

  Fly  1794 --------TASATPSPPRNFSVRVLSPRELEVSWL-------PPEQLRSESVYYTLHWQQELDGE 1843
                    |.|..|....:.:..|||...|.|.|.       |.|.:|.:.|...|....|    
Mouse  1539 LGKEIQGQTKSGVPGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPE---- 1599

  Fly  1844 NVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQA-HATPTKSNSSERLHVRSF--AELPEL 1905
              ...|:.|....:|...    :|.:..|..|.:.|.| |........|..:.|..|  .|.|..
Mouse  1600 --TPLRQGEFPSAKLSLL----ITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSA 1658

  Fly  1906 QLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAG-------------NHTKMV----- 1952
            .:.|  ..||.|.|            :.||:.     |:.|             .|.|..     
Mouse  1659 LVPE--NTSLQLDW------------KARSNV-----NLTGFWFELQKWKYNEFYHVKASCSQGP 1704

  Fly  1953 -----VEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVT 2012
                 :..|||.|.|..|:::.|.....:   ....|.::|....||:||.|:|...::.  .:.
Mouse  1705 VYVCNITDLQPYTSYNIRVVVVYTTGENS---SSIPESFKTKAGVPSKPGIPKLLEGSKN--SIQ 1764

  Fly  2013 WTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQW-LDFCNTTE 2076
            |..|..||:.:..|.||.             |:..|..|..|          ..:| :.|..:..
Mouse  1765 WEKAEDNGSRLMYYTLEV-------------RKGISNDSQNQ----------SSRWKVVFNGSCS 1806

  Fly  2077 LSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERV--AEPFVSPEKRGSLVLAIIAPAAIVSS 2139
            ..|..:|.:......||..|.: |.|.|.|||.||.:  .|..|...:. |.:|.||....:|::
Mouse  1807 SICTWRSKNLKGTFQFRAVAAN-EIGLGEYSEISEDITLVEDGVWITET-SFILTIIVGIFLVAT 1869

  Fly  2140 CVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTL-QTQQQLMAVRNRAFSTTLSDA------- 2196
            ..|..|..|.::..  :|.|          ..||.| ...::|..:|..|....|::|       
Mouse  1870 VPLTFVWHRSLKSH--KASK----------EGLSVLNDNDKELAELRGLAAGVGLANACYAVHTV 1922

  Fly  2197 ----DIALLPQINWSQLKLLRFLGSGAFGEVYEGQ----LKTEDSEEPQRVAIKSLRKGAS--EF 2251
                :|..||.....:|.|...||||||||||||.    |.....|  .:||:|:|:||::  |.
Mouse  1923 PTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAIDILGVGSGE--IKVAVKTLKKGSTDQEK 1985

  Fly  2252 AELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLS 2316
            .|.|:||.|||.|.|.||:..:|:|...|...:|:|.||.||||||||.||.|:...|    .|:
Mouse  1986 IEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGP----SLT 2046

  Fly  2317 LSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY 2381
            |.:|:.:|:|::.||.|||.|||:|||||.|||||  |.......|.||||||||||:|||:|||
Mouse  2047 LLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLV--SVKDYTSPRVVKIGDFGLAREIYKNDYY 2109

  Fly  2382 RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRL 2446
            ||.||||||||||:||:|:||:||:|||||:||:|.|||||||.|||.|.:|.:||.:|:.||||
Mouse  2110 RKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRL 2174

  Fly  2447 QQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI-STDLRRTQMASATADT--VVSCSRPE 2508
            :.|..|.:.|::|:..||..:|.:||:|....|.|... :..|.........|.|  |::..   
Mouse  2175 EPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNVSHCGEAAPTGGVINKG--- 2236

  Fly  2509 FKVRFDGQPLEEHREHNERPEDENLTLRE---VPLKDKQLYANEGVS 2552
                |:|:            :||.:||..   :|:...:....||::
Mouse  2237 ----FEGE------------DDEMVTLNSDDTMPVALMETKNQEGLN 2267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470 26/82 (32%)
FN3 826..921 CDD:238020 31/98 (32%)
LY 993..1026 CDD:214531 11/39 (28%)
FN3 1292..1374 CDD:214495 22/87 (25%)
FN3 1799..1897 CDD:238020 23/105 (22%)
FN3 1993..2111 CDD:238020 30/118 (25%)
Pkinase_Tyr 2209..2481 CDD:285015 151/277 (55%)
PTKc_c-ros 2213..2483 CDD:270640 150/275 (55%)
Ros1XP_011241449.1 FN3 112..179 CDD:214495 22/98 (22%)
FN3 207..291 CDD:238020 30/89 (34%)
FN3 568..664 CDD:238020 31/102 (30%)
FN3 1037..1143 CDD:238020 26/108 (24%)
FN3 1552..1631 CDD:238020 20/88 (23%)
FN3 1651..1742 CDD:238020 21/112 (19%)
FN3 1747..1840 CDD:238020 30/118 (25%)
PTKc_c-ros 1949..2210 CDD:270640 145/268 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847458
Domainoid 1 1.000 291 1.000 Domainoid score I1536
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2207
Inparanoid 1 1.050 515 1.000 Inparanoid score I1285
Isobase 1 0.950 - 0 Normalized mean entropy S6145
OMA 1 1.010 - - QHG47409
OrthoDB 1 1.010 - - D27151at33208
OrthoFinder 1 1.000 - - FOG0006628
OrthoInspector 1 1.000 - - oto93820
orthoMCL 1 0.900 - - OOG6_108587
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4461
SonicParanoid 1 1.000 - - X5629
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.650

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