DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and Mst1r

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	XP_006511717.1	Gene:	Mst1r / 19882	MGIID:	99614	Length:	1406	Species:	Mus musculus

Alignment Length:	1584	Identity:	351/1584 - (22%)
Similarity:	535/1584 - (33%)	Gaps:	528/1584 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1154 RARLVRLAAPLDVMELPT--PDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDDGHWDDF 1216
            |.:.:.||||..:.....  |:..:...|      .||..|      :||      ::.||...|
Mouse   152 RGKALHLAAPACLFSANNNKPEACTDCVA------SPLGTR------VTV------VEQGHASYF 198

  Fly  1217 HVRW----QPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRTAWRS 1277
            :|..    :.:.|....|||.|.|     :..|......|..|:.||:......|...  .::.|
Mouse   199 YVASSLDPELAASFSPRSVSIRRL-----KSDTSGFQPGFPSLSVLPKYLASYLIKYV--YSFHS 256

  Fly  1278 GDTTRVQLTTPPVA-PSQPRRLRVFVERLATALQEANVSAVL-----------RWDAPEQGQEAP 1330
            ||.... ||..|:: .|.|..|...:.||.....|......|           |..|||..|  |
Mouse   257 GDFVYF-LTVQPISVTSPPSALHTRLVRLNAVEPEIGDYRELVLDCHFAPKRRRRGAPEGTQ--P 318

  Fly  1331 MQALEYHISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHALHVA 1395
            ...|:...|..|.::|..||.:::.            |...|.|...|...|:..|..|
Mouse   319 YPVLQAAHSAPVDAKLAVELSISEG------------QEVLFGVFVTVKDGGSGMGPNS------ 365

  Fly  1396 PEVQAVPRVLYANAEFIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVPGS 1460
                                          |..|.|:.||        .:.:.|.||...|...|
Mouse   366 ------------------------------VVCAFPIYHL--------NILIEEGVEYCCHSSNS 392

  Fly  1461 APAKLARMRAEVLALAVDWIQRIVYWAEL---DATAPQAAIIY----------RLDLCNFEGKIL 1512
                     :.:|:..:|:.|...:....   :|:.|.:...|          |:||  |.| :|
Mouse   393 ---------SSLLSRGLDFFQTPSFCPNPPGGEASGPSSRCHYFPLMVHASFTRVDL--FNG-LL 445

  Fly  1513 QGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSELEWATVQPLIRLHA 1577
            ...:|.:....||....||                                            |.
Mouse   446 GSVKVTALHVTRLGNVTVA--------------------------------------------HM 466

  Fly  1578 GSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSI 1642
            |:::            |::...::||.|                          .||..|.|:|:
Mouse   467 GTVD------------GRVLQVEIARSL--------------------------NYLLYVSNFSL 493

  Fly  1643 RAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMI 1707
            .:.|            :|....:.:..|.         ||.:||..:.|.
Mouse   494 GSSG------------QPVHRDVSRLGND---------LLFASGDQVFKV--------------- 522

  Fly  1708 TASEDCPLPIPGVRYQL-------------------NLTLAKE-PGSEEHDHGMEPLGQWLLGAG 1752
                  |:..||.|:.|                   .....|| |||.:.||....:.::...:|
Mouse   523 ------PIQGPGCRHFLTCWRCLRAQRFMGCGWCGDRCDRQKECPGSWQQDHCPPEISEFYPHSG 581

  Fly  1753 ESLNLTDLLPFTRYRVSGILSSFY-QKKLALP------TLVLAPLELLTASATPSPPRNFSVR-V 1809
                  .|...||..:.|  |:|| :....:|      |:..:|..||...:  |.||..|:: .
Mouse   582 ------PLRGTTRLTLCG--SNFYLRPDDVVPEGTHQITVGQSPCRLLPKDS--SSPRPGSLKEF 636

  Fly  1810 LSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTH-RLTGIKPGS 1873
            :...|.|:..|..:.:.:.::...:        .|:              .||.| |:.||....
Mouse   637 IQELECELEPLVTQAVGTTNISLVI--------TNM--------------PAGKHFRVEGISVQE 679

  Fly  1874 GYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAE 1938
            |:| :|:...|..|.:...|.. .::..| |.|.|.:|. |.::...||         :||  .|
Mouse   680 GFS-FVEPVLTSIKPDFGPRAG-GTYLTL-EGQSLSVGT-SRAVLVNGT---------QCR--LE 729

  Fly  1939 QLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYH----------------------- 1980
            |:..    .....|..|.....|....|.:|.|..||:..:|
Mouse   730 QVNE----EQILCVTPPGAGTARVPLHLQIGGAEVPGSWTFHYKEDPIVLDISPKCGYSGSHIMI 790

  Fly  1981 -------------------GTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGN------- 2019
                               .|.|..:..|....|  :.:...:.|.|.|.....|.||
Mouse   791 HGQHLTSAWHFTLSFHDGQSTVESRQCAGQFVEQ--QQRRCRLPEYVVRNPQGWATGNLSVWGDG 853

  Fly  2020 GAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDF---CNTTELS--- 2078
            .|...|.....|...|.:|          .|.:|..| .|..|.||...|..   |.|..::
Mouse   854 AAGFTLPGFRFLPPPSPLR----------AGLVELKP-EEHSVKVEYVGLGAVADCVTVNMTVGG 907

  Fly  2079 -------------------------------CIVKSLHSSRLLLFRVRARSLEHGWGPYSEESER 2112
                                           |:....|    :|.:| .||     .| ...|:|
Mouse   908 EVCQHELRGDVVICPLPPSLQLGKDGVPLQVCVDGGCH----ILSQV-VRS-----SP-GRASQR 961

  Fly  2113 VAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQT 2177
            :            |::|::....:|:...:||:...:.:|::|.|..|...:...|....|....
Mouse   962 I------------LLIALLVLILLVAVLAVALIFNSRRRKKQLGAHSLSPTTLSDINDTASGAPN 1014

  Fly  2178 QQQLMAVRN-------RAFSTTLSDADIALLPQIN-----WSQLKLL--RFLGSGAFGEVYEGQL 2228
            .::....|:       |..|..|.|.|..||.::.     ..|:.:.  :.:|.|.||.||.|:.
Mouse  1015 HEESSESRDGTSVPLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEY 1079

  Fly  2229 KTEDSEEPQRVAIKSLRK--GASEFAELLQEAQLMSNFKHENIVCLVGICFDTESI-SLIMEHME 2290
             |:.::.....|||||.:  ...|....|:|..||....|.||:.|:||....|.: .:::.:|.
Mouse  1080 -TDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMR 1143

  Fly  2291 AGDLLSYLRAARATSTQEP---------------------QPTAGLSLSELLAMCIDVANGCSYL 2334
            .||||.::|:.:..|...|                     .||    :.:|::..:.||.|..||
Mouse  1144 HGDLLHFIRSPQRVSDHCPGWEVSASTHPCLRSPVTLCPQNPT----VKDLVSFGLQVACGMEYL 1204

  Fly  2335 EDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY--RKEGEGLLPVRWMSPE 2397
            .:..|||||||.|||::.||.       |||:.||||||.:...:||  |:.....|||:||:.|
Mouse  1205 AEQKFVHRDLAARNCMLDESF-------TVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALE 1262

  Fly  2398 SLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLL 2462
            ||....|||:||||:||||.||:||.|..||...:.|::...:.:|.||.||..|.:.||.::|.
Mouse  1263 SLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLR 1327

  Fly  2463 CWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVR----FDG-------Q 2516
            ||..||..||:||       |:..::::. :||...|..|..:.....|.    .||       |
Mouse  1328 CWEADPAARPTFR-------ALVLEVKQV-VASLLGDHYVQLTAAYVNVGPRAVDDGSVPPEQVQ 1384

  Fly  2517 PLEEHREHNERPEDENLTLREVPL 2540
            |..:|.....:|.    .|.|.||
Mouse  1385 PSPQHCRSTSKPR----PLSEPPL 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495	21/92 (23%)
		FN3	1799..1897	CDD:238020	20/99 (20%)
		FN3	1993..2111	CDD:238020	29/161 (18%)
		Pkinase_Tyr	2209..2481	CDD:285015	109/299 (36%)
		PTKc_c-ros	2213..2483	CDD:270640	109/295 (37%)
Mst1r	XP_006511717.1	Sema_RON	29..525	CDD:200540	107/592 (18%)
		PSI	528..570	CDD:214655	10/41 (24%)
		IPT	571..685	CDD:387656	29/146 (20%)
		IPT_plexin_repeat2	686..770	CDD:238584	24/101 (24%)
		IPT	771..864	CDD:214657	12/94 (13%)
		PKc_like	1064..1352	CDD:389743	110/307 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810