Protein Alignment sev and frk-1

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001369901.1
• Gene: frk-1 / 191635
• WormBaseID: WBGene00001487
• Length: 390
• Species: Caenorhabditis elegans
• Alignment Length: 295
• Identity: 89/295 - (30%)
• Similarity: 155/295 - (52%)
• Gaps: 46/295 - (15%)

  Fly  2204 INWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKH 2266
            ||...:...:.||.||||:|:..:|   |....|.||:|::|..|:..|.|  ::||:||..::|
 Worm   126 INHDSIVANKKLGEGAFGDVFIAEL---DQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQH 187

  Fly  2267 ENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGC 2331
            :::|.|:|:......:.::||:...|.|||:|:..:            :||.|.|....:.|:|.
 Worm   188 KHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHLKKNK------------VSLIEKLRFTTEAADGI 240

  Fly  2332 SYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLA--RDIYKSDYYRKEGEGLLPVRWM 2394
            :|||....:|||:|.||||::       .:..:||.|||::  :|..|.:...|     :|::|:
 Worm   241 AYLERSKCIHRDIAARNCLLS-------AKNELKISDFGMSDNKDEIKDETLEK-----VPIKWL 293

  Fly  2395 SPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAH-VKEGGRLQQP----PMCTE 2454
            :||::.:.::|.::|:|.||||.|||.:.|.:||......:..|. |....|::.|    |...:
 Worm   294 APETMQEKVYTHKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVAD 358

  Fly  2455 KLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLR 2489
            .:..   .||:.:|.:|       :|:.:|...||
 Worm   359 VVTG---TCWQKNPEKR-------STMDSIHKKLR 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020
		PTKc_c-ros	2213..2483	CDD:270640	84/278 (30%)
frk-1	NP_001369901.1	SH2_Fps_family	16..107	CDD:198224
		TyrKc	131..382	CDD:197581	85/287 (30%)