Protein Alignment sev and Y47G6A.5

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_491175.2
• Gene: Y47G6A.5 / 189992
• WormBaseID: WBGene00021635
• Length: 618
• Species: Caenorhabditis elegans
• Alignment Length: 636
• Identity: 165/636 - (25%)
• Similarity: 264/636 - (41%)
• Gaps: 137/636 - (21%)

  Fly  1935 SSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGK- 1998
            ||.|...|.|....|..|..|.:|                 .||...|..|..|....|..|.:
 Worm    35 SSQELALRPVMPESTPSVAVPAKP-----------------PPLRPSTQSVSSTDPRPPIPPRRS 82

  Fly  1999 ------PQLEHIAEEVFR---VTWTAARGNGA-----PIALYNLEALQARSDIRRRRRRRRRNSG 2049
                  |.:.|.:..:.|   .|.|.:..|||     |::                :......|.
 Worm    83 ESNLVPPPIPHHSGNISRHPSATSTKSVPNGASFSPRPVS----------------KTHSHHGSA 131

  Fly  2050 GSLEQLPWAEEPVVVEDQWLDFCNT-TELSC----IVKSLHSSRLLLFRVRARSLE-HGWGP--- 2105
            ......| .|:.::||:::|  ..| .|:|.    ::..:..|....:.|.::|.: .|:.|
 Worm   132 KCSHSEP-EEKMLIVENRFL--AQTPKEMSVEEGDVLYLIEQSNREWWYVASKSRQFKGFVPKSH 193

  Fly  2106 --YSEESE--------------RVAEP------FVSPE--KRGSLVLAIIAPAAIVSSCVLALVL 2146
              |:|..|              ||.:|      |:..|  |..:.||.:   .:..:....|.::
 Worm   194 VVYAEYREPWFAGNISSILAEQRVMQPQLPIGSFLIRENSKTDTFVLVV---RSSHNESPQAYII 255

  Fly  2147 VRKVQKRRLRAKKLLQQSRPSI--WSNLSTLQTQQQLMAVRNR-AFSTTLSDADIALLPQ----- 2203
            .|:..:...   ::....||::  :.:|..|........|... ...|.|:.|...|..|
 Worm   256 YRRPNQEGF---EIRDNHRPAVIHFGSLHQLVNHYSCEKVPGEIQICTKLTKAAPPLPEQTEYMA 317

  Fly  2204 -----INWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASE---FAELLQEAQL 2260
                 :|.|:::.::.:|.|.|||||..:.|..|      ||:|||:...||   ..:.|:||:.
 Worm   318 MKKIHVNRSEVRRVKEIGRGQFGEVYLAKWKGVD------VAVKSLKPDHSEQLANTQFLEEAKT 376

  Fly  2261 MSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQP-----------TAG 2314
            ::...|:|::.|:.:|...:...:|.|.|..|.||::|:  :.|.|..|.|           ..|
 Worm   377 LTKLSHQNVIHLLAVCDTDKPYLIITEFMTNGSLLAWLQ--KLTKTLPPIPLMSEETGRKNVLIG 439

  Fly  2315 LSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLAR--DIYK 2377
            .|:|      ..||:|..||.....||||||.||.||  .|.|::....||:.||||||  |:..
 Worm   440 ASIS------AQVASGMDYLSANKIVHRDLAARNVLV--GTVSSNGVPLVKVADFGLARKTDVGD 496

  Fly  2378 SDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKE 2442
            .:|..|. :.:||.:||:||...:.:|.|::|||::|:|.|||.|||:.||...:....|.|:..
 Worm   497 ENYVMKT-DNMLPWKWMAPECFDEQIFNTKTDVWSYGILLWEIGTLGKTPYRGWDYEGTLEHLSR 560

  Fly  2443 GGRLQQPPMCTEKLY-SLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQ 2492
            |..|.:|.:..:.:| ....:|...||..||:|.|.:.....|:.:...:|
 Worm   561 GYVLPRPELVPDYVYEDAFKICVHLDPRRRPTFDRLFKYFDEINCESLSSQ 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020	27/143 (19%)
		PTKc_c-ros	2213..2483	CDD:270640	99/286 (35%)
Y47G6A.5	NP_491175.2	SH3	151..194	CDD:473055	8/42 (19%)
		SH2	202..287	CDD:198173	14/90 (16%)
		PTKc	332..601	CDD:270623	99/285 (35%)