Protein Alignment sev and trk-1

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001360632.1
• Gene: trk-1 / 183575
• WormBaseID: WBGene00017039
• Length: 842
• Species: Caenorhabditis elegans
• Alignment Length: 477
• Identity: 146/477 - (30%)
• Similarity: 232/477 - (48%)
• Gaps: 82/477 - (17%)

  Fly  2105 PYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIW 2169
            ||.:|.:.|            :.|.:|....:||:  ||.....|:|. .||.|.|..:.|.|:.
 Worm   376 PYKQEIQIV------------VFLIVICLLIVVSA--LAFYHRLKLQS-FLREKILSFRKRISLA 425

  Fly  2170 SNLST----LQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKT 2230
            ..|.|    .:|::.|:.:..|  |:..||.....||.|:...:::...||.|.|||||   |.:
 Worm   426 QELQTRRASQETEETLLRLEER--SSLASDYTNMTLPFIDMGNIEIHEMLGKGHFGEVY---LAS 485

  Fly  2231 EDSEEPQRVAIKSLRK--GASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGD 2293
            .|...|:.||:||:|:  .|:|     :||:::.:.:|.|||.|.|:..:..::.|:.|||..||
 Worm   486 WDYTGPRSVAVKSIRRVDMATE-----KEARVLQDLEHPNIVKLYGMTRNNFNLLLVFEHMNHGD 545

  Fly  2294 LLSYL--RA-ARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTEST 2355
            |.:||  || .::...|.|.|   |.:.||..:..::..|..||.:...||||||.|||||   .
 Worm   546 LKTYLEQRAPVKSVYLQYPPP---LVIDELKWIIKEITTGLVYLVEQSIVHRDLAARNCLV---A 604

  Fly  2356 GSTDRRRT---------VKIGDFGLARDIY-KSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDV 2410
            |.:|.:.|         |||.|||::|.:| .|:||..:..|.|||||:.||::....||..||:
 Worm   605 GDSDLKATSHFERPPIRVKISDFGMSRRLYDHSEYYTMDHRGALPVRWLPPEAVQSHKFTYNSDI 669

  Fly  2411 WAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFR 2475
            |:.||..||.::.|:||:...:|.||.:....|.|..:|..|.:.:|.|::.||..:|.:|.:.:
 Worm   670 WSLGVTMWECMSYGRQPFDGLSNLEVSSFTLAGMRPLKPERCPQDMYDLMVKCWHMEPVKRITAK 734

  Fly  2476 -----------------RCYNTLHAISTDL-----RRTQMASATADTVVSCSRPEFKV------- 2511
                             |..|..:::.:..     |...:.:.|:.|....:..|.:|
 Worm   735 QILEDELFDKIREGLPYRAANEANSLVSSCMLNINRYKDVVAETSFTTDPLNSSEIEVNDVPTEN 799

  Fly  2512 -RFDGQPLEEHREHNERPEDEN 2532
             :.:||.:|  :...|:.|.|:
 Worm   800 GKVNGQTVE--KAEYEKSESES 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020	3/5 (60%)
		PTKc_c-ros	2213..2483	CDD:270640	106/301 (35%)
trk-1	NP_001360632.1	PTKc	471..738	CDD:270623	104/280 (37%)