Protein Alignment sev and ver-3

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_509836.1
• Gene: ver-3 / 181289
• WormBaseID: WBGene00006896
• Length: 1227
• Species: Caenorhabditis elegans
• Alignment Length: 1197
• Identity: 245/1197 - (20%)
• Similarity: 406/1197 - (33%)
• Gaps: 449/1197 - (37%)

  Fly  1656 VELEPEEVRLLQAHNY---QAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPI 1717
            :||....|.:.:|..|   |.|           |..:.|....|:|       ::..:.:|
 Worm   162 IELYASNVLVKEASKYNYDQRY-----------GFKITKKLYSEKQ-------IVDVNFEC---- 204

  Fly  1718 PGVRYQLN-------LTLAKEPGSEEHDH-GMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSS 1774
               ||:..       :...||..|::..| ..|...|| ...|.:.:||..|   .|..|.|...
 Worm   205 ---RYKKEENQTATYIITEKEASSDDGYHFSWEKGFQW-PHVGYNFSLTCNL---NYNGSKIFHG 262

  Fly  1775 FYQKKLALPTLVLAPLELLTASATPSPPRNFSV---RVLSPR----------ELEVSWLPPEQLR 1826
            :..|           |.:.....:..|..:..|   |::..:          |||
 Worm   263 YTNK-----------LSIECPQCSHDPGSHVHVDRHRIIGNKISTTVRIQHLELE---------- 306

  Fly  1827 SESVYYTLHWQQELDGENVQDRREWEAHERR----LETAGTHRLTGIKPGSGYSLWVQAHATPTK 1887
             :|..||..|:.|.......|...:.|.::.    :||:.|  :..||.....||..:....|.:
 Worm   307 -DSGKYTCIWEHENKETKYTDYHLYVAPKKAQIKVIETSPT--IMRIKENRATSLTAKFAIYPFE 368

  Fly  1888 SNS----------------------------------------SERLHVRSFAELPELQLLELGP 1912
            ..|                                        ||.|.:::||....:.    |.
 Worm   369 KESYTAKWSRIYNSSIHEGPQSETIINDDFRKIAATSFGDGAFSENLDIKAFAVSTNMS----GT 429

  Fly  1913 YSLSLTWAGT--------------PDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRT--R 1961
            |.||::...|              ||    :|:..|..:.....|         .|..:|.|  .
 Worm   430 YVLSISHMDTVQVVQWEVAIENDEPD----VQITVREPSSFFISN---------QEYYKPDTNLH 481

  Fly  1962 YQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALY 2026
            .:|   :..:..|...::.     |:|......|..:|      .::..|..|..||     .:|
 Worm   482 IEC---ISISIPPADVVFE-----YKTKNSEQFQEIEP------NKLVSVGGTFDRG-----LIY 527

  Fly  2027 NL---EALQAR-SDIRRRRRRRRRNS----GGSLEQLPWAE--------EP--VVVE-------- 2065
            |:   |.:..: |.||:..|....|.    |...|..|..|        ||  ::.|
 Worm   528 NVTFTEGMDLKCSSIRKGNRAITVNKLIKIGEGFEVRPHHEKSSKATESEPSKIIYEGDNVKLTC 592

  Fly  2066 ------DQW--------------LDFCNTTE------------------------LSCIVKSLHS 2086
                  |.|              .....|||                        .:|:||:..|
 Worm   593 VFPLDSDDWSVSWRFENSKSSDISSIPTTTETEIKQYSKHLILNLRDVTTSFTGTYTCVVKNEDS 657

  Fly  2087 SRLLLFRVRARSLE----------------------------------HGW----GPYSE----- 2108
            .:||...:..:::.                                  :.|    .||:.
 Worm   658 EKLLETSIDVKAISKPSITGGNSNAVVIVDYDQYFEINCNMTGTPPPVYQWFKDGNPYTHGDVDG 722

  Fly  2109 -------------------ESERVAEPFVSPE------KRGSL----VLAIIAPAAIVSSCVLAL 2144
                               .:.|..:...|.|      .:|||    .||::...:|::..:|..
 Worm   723 SILRVSRARGEDDGEFHCLATNRAGDKLNSIEVQVNNAPKGSLFFYWFLALLLLISIIAVFLLTC 787

  Fly  2145 VLVRKVQKRRLRAKKLLQQSRPSIWSNL---------STLQTQQQLMAVRNRAFSTTLSDADIAL 2200
                     :|||...|.:.:....:.|         ..|..:.:.:.|..|.:          .
 Worm   788 ---------KLRASNRLTKQKDIALNTLYETMIKHQAGPLPEEMKDLPVEERTY----------Y 833

  Fly  2201 LP-----QINWSQLKLLRFLGSGAFGEVYEGQL-----KTE-DSEEPQRVAIKS--------LRK 2246
            ||     :|:...|::|..:|||.||.|.:|.|     |:: :|:....||:||        |:|
 Worm   834 LPYNNDYEIDPVNLEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQK 898

  Fly  2247 GASEFAELLQEAQLMSNF-KHENIVCLVGICFDTES-----ISLIMEHMEAGDLLSYLRAARATS 2305
            ..:|      |.::|... |:.|::.|:|..  |::     :.::.|.::.|:|..:|:|.|.|.
 Worm   899 MMAE------ELKVMCAIPKNPNVLALIGAV--TKNMRQGQLYIVTEFIDGGNLREFLQAHRNTF 955

  Fly  2306 TQE--------------------------------------PQPTAGLSLSELLAMCIDVANGCS 2332
            ..|                                      ..|.| |..|:||::.:.:|.|.:
 Worm   956 INELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDA-LCTSDLLSIGLQIAKGMA 1019

  Fly  2333 YLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYR--KEGEGLLPVRWMS 2395
            :|.|:..|||||||||.|:|::       :.|:|.||||::......|||  |..:..||||||.
 Worm  1020 WLADVPCVHRDLACRNVLITKT-------KIVRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMP 1077

  Fly  2396 PESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLL 2460
            .|.:.:..||.:||||:||:..:||.|||..||...:.|.|:..::.|.|.:||..|.:::|.|:
 Worm  1078 LECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFNVIEFIRNGNRNKQPEYCHDEIYELM 1142

  Fly  2461 LLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHN 2525
            .:||:.:|.:||:|..|.........|                 |..:|..|.:.....|.:|.:
 Worm  1143 KVCWQFNPKDRPTFNDCITFFENHMRD-----------------SSSQFLERVENMLHTEMQEQS 1190

  Fly  2526 E--------RPEDENLTLREVPLKDKQ 2544
            :        ||:..|::.::.|.|.|:
 Worm  1191 KLDDWIQDSRPDVPNVSFQKSPKKQKE 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	22/147 (15%)
		FN3	1993..2111	CDD:238020	35/249 (14%)
		PTKc_c-ros	2213..2483	CDD:270640	101/329 (31%)
ver-3	NP_509836.1	IG_like	242..>313	CDD:214653	17/95 (18%)
		IG_like	578..667	CDD:214653	13/88 (15%)
		Ig strand B	588..592	CDD:409353	0/3 (0%)
		Ig strand C	602..606	CDD:409353	0/3 (0%)
		Ig strand E	633..637	CDD:409353	0/3 (0%)
		Ig strand F	647..652	CDD:409353	1/4 (25%)
		Ig_3	672..744	CDD:464046	3/71 (4%)
		PTKc	851..1164	CDD:270623	101/328 (31%)