DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and svh-2

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_509104.1	Gene:	svh-2 / 180929	WormBaseID:	WBGene00020504	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	920	Identity:	212/920 - (23%)
Similarity:	353/920 - (38%)	Gaps:	254/920 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1684 SSGGSLLKATDCE----------EQRCLLHLPMITASEDCPLPIPGVRY-------QLNLTLAKE 1731
            |..||..|.|.|:          ::.||.:    :..:|...|...|||       ...|..||
Worm   330 SFSGSTAKTTRCKYPQIFDQMKVKKGCLTY----SRLDDESSPTLCVRYGRGDALDNCQLHTAK- 389

  Fly  1732 PGSEEHDHGMEPLGQWLLGAGESLNLT--DLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLT 1794
              |..:.:|      ||    |..|:.  :|:....|...||..|                 |:|
Worm   390 --SNSYRYG------WL----EDYNVLQGELMMRIPYPFFGIAES-----------------LIT 425

  Fly  1795 ASATPSPPRNFSVRVLSPRELEVSWLPPEQLR---SESVYYTLHWQQELDGENVQDRREWEAHER 1856
            ..      :::...|..  |.::|    :.||   |||.....||:
Worm   426 DG------KSYFAAVSG--EFDMS----DVLRFSASESADIRPHWR------------------- 459

  Fly  1857 RLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAG 1921
                      |.|.....:|:      |.||.|......|.....| ::....|.|...:|...|
Worm   460 ----------TNISVVGKFSI------TKTKENQLLYTTVEGLQSL-DISCKGLYPNCQTLRQGG 507

  Fly  1922 TPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQC----RLLLGYAATPGAPLYHGT 1982
            ..||     |||...|:.   |.....|...|...:...:::|    |.:..|....|   :...
Worm   508 WEDP-----LECSWCADD---NAQRTITSSEVSSCKNNLKHECPPSMRWIHKYNNNSG---FTAV 561

  Fly  1983 AEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRN 2047
            .:.:..|.:       |:|.             |.|....:.:.:..::|..::
Worm   562 VDGFRALKN-------PKLN-------------ACGTNCVVTVVDSSSIQCDTN----------- 595

  Fly  2048 SGGSLEQLPWAEEPVVVEDQWL-DFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYS-EES 2110
                             .|:.: |.|....||.::...:.|                .|:. :::
Worm   596 -----------------PDEVIGDSCKQVFLSGMIGDKNYS----------------FPFDYQQA 627

  Fly  2111 ERVAEPFVS----PEKRGS-----LVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRP 2166
            :|..:..|.    .:|:||     :.:|||:...|:  .::|::    |...|.|..::....||
Worm   628 DRGTQTDVKNSQVDDKKGSSPGWKIAIAIISVMTII--LIVAII----VYYMRNRFPRIKTHVRP 686

  Fly  2167 SIWSNLST------LQTQQQLMAVRN----RAFSTTLSDADIALLPQINWSQLKL--LRFLGSGA 2219
            .|...:..      :..:|..:|:..    :.|.:...|.      ::::..|::  |..:|.|.
Worm   687 PIGQRIENEYDMGHMAGRQAQLAINGDNYVKVFRSMRPDL------KVDFKNLRVDKLDPIGQGH 745

  Fly  2220 FGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTES--I 2282
            :|.||:.......|.| ::|..|.|::|  :.:|..:||:.||.|.|.||:.|:|:..|..|  .
Worm   746 YGVVYKAMYSPSKSLE-EKVVCKYLKEG--KISEFYEEARTMSEFDHPNILKLIGVALDDSSHLP 807

  Fly  2283 SLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACR 2347
            .:|.|:|..|||.|::.....|          :.:.:|.....|:|.|.:|:....|:|||||||
Worm   808 IIITEYMAKGDLKSFIENVENT----------IKMRDLFEFAFDIAKGMNYMHSKKFIHRDLACR 862

  Fly  2348 NCLVTESTGSTDRRRTVKIGDFGLARDI-YKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVW 2411
            |||:       |....|||.||||.|.: .:::.|.:..|..|||||..||....| |...||:|
Worm   863 NCLL-------DEHLRVKIADFGLCRKVDIETELYVQMHERDLPVRWFPPEISEQG-FGITSDIW 919

  Fly  2412 AFGVLCWEILTLGQQPYAARNNF-EVLAHVKEG--GRLQQPPMCTEKLYS-LLLLCWRTDPWERP 2472
            :|||:.||:.|.|..||:...:: .:|..:||.  .||::||.|.||||: ::|.||:.:|.|||
Worm   920 SFGVVIWELFTRGSTPYSNMASWILILPWLKESETNRLRKPPYCPEKLYTDVMLACWKANPAERP 984

  Fly  2473 SFRRCYNTLHAISTDLR---RTQMASA---TADTVVSCSR--PEFKVRFDGQPLEEHREHNERPE 2529
            .|......:..:...:.   |:|:.:.   .:...:|.||  |.|.:..:..|......:.:...
Worm   985 QFSDLVTIIPNVVKYMEGYDRSQLQAGYERVSSRFLSLSRHDPAFPIYQNEMPNTPLLANCQNDT 1049

  Fly  2530 DENLTLREVP 2539
            :::.||.|:|
Worm  1050 NDSKTLAELP 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	17/100 (17%)
		FN3	1993..2111	CDD:238020	12/119 (10%)
		Pkinase_Tyr	2209..2481	CDD:285015	102/280 (36%)
		PTKc_c-ros	2213..2483	CDD:270640	100/276 (36%)
svh-2	NP_509104.1	TyrKc	735..993	CDD:197581	101/278 (36%)
svh-2	NP_509104.1	PTKc	739..993	CDD:270623	100/274 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910