DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sev and F11E6.8

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_001255960.1	Gene:	F11E6.8 / 178530	WormBaseID:	WBGene00008711	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	136/447 - (30%)
Similarity:	213/447 - (47%)	Gaps:	85/447 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  2065 EDQWLDFCN--TTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLV 2127
            |.:|| |..  ||..|.|:|:..::.:.|..:...||                         :|:
Worm    14 ELEWL-FPKEVTTSSSAILKNKSAAEIPLNFLAEHSL-------------------------ALI 52

  Fly  2128 LAIIAPAAIVSSCVLALVLVRKVQKRR----LRAKKLLQQS---RPSIWSNLSTLQTQQQLMAVR 2185
            .|:.  ..:::..:||:::....||..    |.|..:..:|   .||.|:..||:.:.....::.
Worm    53 AALF--LVVLTVALLAVLVQYHCQKGTNSGGLGAGAISPKSFSTSPSQWTTCSTVSSTYSTQSLL 115

  Fly  2186 NRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQ----RVAIKSLR- 2245
            ....|.........|||.   ..:.|...:|.|.||.||.|:::     :|.    .||:|:|:
Worm   116 QLIGSDLRQSLQGLLLPS---EAVVLETIVGKGYFGNVYRGRMR-----DPAGRLIPVAVKTLKG 172

  Fly  2246 ---KGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESIS------LIMEHMEAGDLLSYLRAA 2301
               :..:...:.|:|..:|.:..|.:::.|:||     |||      :::.:||.|||.:|:
Worm   173 ERARDIAHIEKFLREGVVMKHLDHPHVLSLLGI-----SISPAGNPWVVLPYMEGGDLKTYI--- 229

  Fly  2302 RATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKI 2366
                   ..|...|.:.|||.....||.|.|||...||||||||.|||::     |.|  |.||:
Worm   230 -------ADPNRALCVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMI-----SAD--RIVKV 280

  Fly  2367 GDFGLARDIYKSDYYRKE---GEGLLPVRWMSPESLVD-GLFTTQSDVWAFGVLCWEILTLGQQP 2427
            .|||||.|:...:.|..|   |...||::|::||||.| .:|::.:|||:||||.||:||....|
Worm   281 ADFGLAVDLLDKESYIDESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASP 345

  Fly  2428 YAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI 2484
            |...:|.:|..:::.|.||.||..|.:.:|.|:..|||:.|.:||.|....:.|.|:
Worm   346 YGEVSNTKVRHYLETGMRLPQPTHCPDIIYDLMQCCWRSTPEDRPDFVFLSHRLRAL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020	12/47 (26%)
		Pkinase_Tyr	2209..2481	CDD:285015	104/289 (36%)
		PTKc_c-ros	2213..2483	CDD:270640	104/287 (36%)
F11E6.8	NP_001255960.1	PTKc	141..400	CDD:270623	103/285 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910