DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and Met

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_032617.2 Gene:Met / 17295 MGIID:96969 Length:1379 Species:Mus musculus


Alignment Length:1369 Identity:303/1369 - (22%)
Similarity:480/1369 - (35%) Gaps:458/1369 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1327 QEAPMQALEYHIS----CWVGSELHE--ELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAA 1385
            |:..:.|..:|..    |.|.|.||.  |:.|.....|.|.:....::.::....|.|:..||  
Mouse   264 QKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGA-- 326

  Fly  1386 GAASHALHVAPEVQAVPR----------------------------VLYANAEFIGELDLDTRNR 1422
                   ::|.::.|.|.                            :.|.| :|..:: ::..|.
Mouse   327 -------NLAKQIGASPSDDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVN-DFFNKI-VNKNNV 382

  Fly  1423 RRLVHTASPVEHLVGIEGEQRLLWVNEHV---ELLTHVPGSAPAKLARMRAEVLALAVDWIQRI- 1483
            |.|.|...| .|              ||.   .||.:..| ..|:....|.|....    :||: 
Mouse   383 RCLQHFYGP-NH--------------EHCFNRTLLRNSSG-CEARSDEYRTEFTTA----LQRVD 427

  Fly  1484 VYWAELD---ATAPQAAIIYRLDLCNF---EGKILQ---GERVWSTPRGRLLKDLVALPQAQSLI 1539
            ::...|:   .|:....|...|.:.|.   ||:.:|   ......||....|.|  :.|.:..:|
Mouse   428 LFMGRLNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLLD--SHPVSPEVI 490

  Fly  1540 WLEYEQGSPRNG---SLRGRNLTDGSELEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDV 1601
               .|..|.:||   .:.|:.:|.         .||..|..|..:..|:.|:        ..|.:
Mouse   491 ---VEHPSNQNGYTLVVTGKKITK---------IPLNGLGCGHFQSCSQCLS--------APYFI 535

  Fly  1602 ARQLCTASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLL 1666
            ....|....:|.      ::..:|             .|:                   :|:.|.
Mouse   536 QCGWCHNQCVRF------DECPSG-------------TWT-------------------QEICLP 562

  Fly  1667 QAHNYQAYPPKNCLLLPSSGGSLLKATDC--------EEQRCLLHLPMITASEDCPLPI------ 1717
            ..  |:.:|..    .|..||::|  |.|        ..:..|....::..:|.|.|.:      
Mouse   563 AV--YKVFPTS----APLEGGTVL--TICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTN 619

  Fly  1718 -------PGVRYQLNLTLAKEPGSEEHDHG----MEPLGQWLLGAGESLNLTDLLPFTRY--RVS 1769
                   |.:....|:::......|...:.    ::|:            :|.:.|  ||  :..
Mouse   620 TLKCTVGPAMSEHFNVSVIISNSRETTQYSAFSYVDPV------------ITSISP--RYGPQAG 670

  Fly  1770 GILSSFYQKKL---------------ALPTLVLAPLELLTASATPSPPRNFSVRV---LSPRELE 1816
            |.|.:...|.|               .|.::..:.||..|.:.|.|.  .|.|::   |:.||  
Mouse   671 GTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTSD--EFPVKLKIDLANRE-- 731

  Fly  1817 VSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGI-KPGSGYS---L 1877
                      :.|..|.            :|...:|.|..:...:|...:||| |..:..|   |
Mouse   732 ----------TSSFSYR------------EDPVVYEIHPTKSFISGGSTITGIGKTLNSVSLPKL 774

  Fly  1878 WVQAHATPTKSNSSERLHVRSFAEL-----PELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSA 1937
            .:..|....  |.:.....||.:|:     |.|:  :||                 |||..::.|
Mouse   775 VIDVHEVGV--NYTVACQHRSNSEIICCTTPSLK--QLG-----------------LQLPLKTKA 818

  Fly  1938 EQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLE 2002
            ..|...:...|..                 |.|...|          |:|     |.:  ||.:.
Mouse   819 FFLLDGILSKHFD-----------------LTYVHNP----------VFE-----PFE--KPVMI 849

  Fly  2003 HIA-EEVFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVV--V 2064
            .|. |.|..:     :||       |::....:.::.:...:       |.|.|.|....|:  |
Mouse   850 SIGNENVVEI-----KGN-------NIDPEAVKGEVLKVGNQ-------SCESLHWHSGAVLCTV 895

  Fly  2065 EDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLA 2129
            ....|..  .:||:...|...||.:|                       .:..|.|::.   ...
Mouse   896 PSDLLKL--NSELNIEWKQAVSSTVL-----------------------GKVIVQPDQN---FAG 932

  Fly  2130 IIAPAAIVSSCVLAL----VLVRKVQKRRLRAKKLLQQSR------------------------- 2165
            :|..|..:|..||.|    :.:||.:.:.|.::.:...:|                         
Mouse   933 LIIGAVSISVVVLLLSGLFLWMRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNE 997

  Fly  2166 -------------PSIWSNLSTLQTQQQLMAVRNRAFSTTLS------DADI------------- 2198
                         |:...|.:..|.|..|         |.||      |:||             
Mouse   998 SVDYRATFPEDQFPNSSQNGACRQVQYPL---------TDLSPILTSGDSDISSPLLQNTVHIDL 1053

  Fly  2199 -ALLPQ---------INWSQLKLLRF---LGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRK--GA 2248
             ||.|:         |..|.| ::.|   :|.|.||.||.|.|...|.:: ...|:|||.:  ..
Mouse  1054 SALNPELVQAVQHVVIGPSSL-IVHFNEVIGRGHFGCVYHGTLLDNDGKK-IHCAVKSLNRITDI 1116

  Fly  2249 SEFAELLQEAQLMSNFKHENIVCLVGICFDTESISL-IMEHMEAGDLLSYLRAARATSTQEPQPT 2312
            .|.::.|.|..:|.:|.|.|::.|:|||..:|...| ::.:|:.|||.:::|    ..|..|   
Mouse  1117 EEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR----NETHNP--- 1174

  Fly  2313 AGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYK 2377
               ::.:|:...:.||.|..||....|||||||.|||::       |.:.|||:.|||||||:|.
Mouse  1175 ---TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCML-------DEKFTVKVADFGLARDMYD 1229

  Fly  2378 SDYY---RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAH 2439
            .:||   .|.| ..|||:||:.|||....|||:||||:||||.||::|.|..||...|.|::..:
Mouse  1230 KEYYSVHNKTG-AKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIY 1293

  Fly  2440 VKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADTV-VS 2503
            :.:|.||.||..|.:.||.::|.||......||||....:.:.:|.:...........|..| |.
Mouse  1294 LLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVK 1358

  Fly  2504 CSRP 2507
            |..|
Mouse  1359 CVAP 1362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495 12/52 (23%)
FN3 1799..1897 CDD:238020 20/104 (19%)
FN3 1993..2111 CDD:238020 22/120 (18%)
Pkinase_Tyr 2209..2481 CDD:285015 109/280 (39%)
PTKc_c-ros 2213..2483 CDD:270640 108/278 (39%)
MetNP_032617.2 Sema 25..515 CDD:387663 59/295 (20%)
PSI 518..560 CDD:214655 9/87 (10%)
IPT_plexin_repeat1 562..655 CDD:238585 15/100 (15%)
IPT_plexin_repeat2 656..739 CDD:238584 22/122 (18%)
IPT 741..836 CDD:387656 26/132 (20%)
IPT_PCSR 838..917 CDD:238337 23/116 (20%)
PTKc_Met_Ron 1080..1341 CDD:270649 108/279 (39%)
Interaction with RANBP9. /evidence=ECO:0000250 1210..1379 64/161 (40%)
Interaction with MUC20. /evidence=ECO:0000250 1318..1357 8/38 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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