Protein Alignment sev and spe-8

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_490680.1
• Gene: spe-8 / 171606
• WormBaseID: WBGene00004962
• Length: 512
• Species: Caenorhabditis elegans
• Alignment Length: 286
• Identity: 86/286 - (30%)
• Similarity: 140/286 - (48%)
• Gaps: 39/286 - (13%)

  Fly  2153 RRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLP-------QINWSQLK 2210
            :|.:.|||       .|:.....::..:|:|...|.......  .:.|:.       |:|..|:.
 Worm   163 KRTKTKKL-------YWTKKYAFKSICELIAYHKRNHKPIYE--GMTLICGLARHGWQLNNEQVT 218

  Fly  2211 LLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRK---GASEFAELLQEAQLMSNFKHENIVCL 2272
            |.:.||.|.||||::|.|||.....|..||:|:|.:   .|:|....|:||.:|....|.|::..
 Worm   219 LNKKLGEGQFGEVHKGSLKTSVFAAPVTVAVKTLHQNHLSANEKILFLREANVMLTLSHPNVIKF 283

  Fly  2273 VGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDM 2337
            .|:|...|.|.::||..:...|...|     .|.:|.     :|..:.:......|.|..||...
 Worm   284 YGVCTMKEPIMIVMEFCDGKSLEDAL-----LSKEEK-----VSAEDKILYLFHAACGIDYLHGK 338

  Fly  2338 HFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDG 2402
            ..:|||:|.||||:       :.::.:||.||||:   .|....::...|.|||::|:||:|..|
 Worm   339 QVIHRDIAARNCLL-------NSKKILKISDFGLS---VKGVAIKERKGGCLPVKYMAPETLKKG 393

  Fly  2403 LFTTQSDVWAFGVLCWEILTLGQQPY 2428
            |::|.||::::|.|.:|:.|.|:.|:
 Worm   394 LYSTASDIYSYGALMYEVYTDGKTPF 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996
		FN3	1993..2111	CDD:238020
		PTKc_c-ros	2213..2483	CDD:270640	73/219 (33%)
spe-8	NP_490680.1	SH2_Fps_family	109..195	CDD:198224	8/38 (21%)
		PTKc	221..476	CDD:270623	73/219 (33%)