DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and Insr

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_001316985.1 Gene:Insr / 16337 MGIID:96575 Length:1384 Species:Mus musculus


Alignment Length:1177 Identity:284/1177 - (24%)
Similarity:438/1177 - (37%) Gaps:374/1177 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1583 GSETLNLVDNQGKLCVYDVARQL--CTASALRAQLNLLGEDSIAGQLAQD-------SGYL---- 1634
            |.:|::.|.:         |::|  ||.......:|:.|.:::|.:|..:       ||:|    
Mouse   344 GEKTIDSVTS---------AQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRR 399

  Fly  1635 -YA-------------------VKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNC 1679
             ||                   :.|:|.  |....|.|....:.....:.:.|...:..|.||.|
Mouse   400 SYALVSLSFFRKLHLIRGETLEIGNYSF--YALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLC 462

  Fly  1680 L---------------------LLPSSGGSLLKATDCEEQRCLLHLPMITASEDC------PLPI 1717
            |                     .|.::|..    ..||.:  ||....|..|.|.      |...
Mouse   463 LSEIHKMEEVSGTKGRQERNDIALKTNGDQ----ASCENE--LLKFSFIRTSFDKILLRWEPYWP 521

  Fly  1718 PGVR-------------YQLNLT----------------------LAKEPGSEEHDH------GM 1741
            |..|             || |:|                      .:.:|.|:...|      |:
Mouse   522 PDFRDLLGFMLFYKEAPYQ-NVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGL 585

  Fly  1742 EPLGQWLLGAGESLNLTDLLPFTRYRVSGILSS--FYQKKLALPTLVLAPLELLTASATPSPPRN 1804
            :|..|:.:.....:..:|     ..|..|..|.  :.|.....|::.|.|:.:..:|:       
Mouse   586 KPWTQYAIFVKTLVTFSD-----ERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSS------- 638

  Fly  1805 FSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGI 1869
                     ::.:.|.||........:|.::|:::     .:|...:|.         .:.|.|:
Mouse   639 ---------QIILKWKPPSDPNGNITHYLVYWERQ-----AEDSELFEL---------DYCLKGL 680

  Fly  1870 KPGSGYSLWVQAHATPTKSNSSERLHVRSFAE---------------LPELQ------------- 1906
            |..|  ..|    :.|.:|:.|::.:...:.:               |.||:             
Mouse   681 KLPS--RTW----SPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLH 739

  Fly  1907 --------------------------LLELGPYSLSLTWAGTPD-PLGSLQLECRSSAEQLRRNV 1944
                                      |.|:|  :::.|....|| |..|..:...|..|......
Mouse   740 NVVFVPRKTSSGNGAEDSRPSRKRRSLEEVG--NVTATTLTLPDFPNVSSTIVPTSQEEHRPFEK 802

  Fly  1945 AGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVF 2009
            ..|...:|:..|:..|.|:..|   .|....:|....:...|.:....|.......:..:..|:|
Mouse   803 VVNKESLVISGLRHFTGYRIEL---QACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIF 864

  Fly  2010 -----RVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWL 2069
                 .:.|...:.....|.||         ::..||                      ..|:.|
Mouse   865 ENNVVHLMWQEPKEPNGLIVLY---------EVSYRR----------------------YGDEEL 898

  Fly  2070 DFCNT-----TELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEES-----------ERVAEPFV 2118
            ..|.:     .|..|.::.|......: ||||.||. |.|.::|.:           ..:|:..:
Mouse   899 HLCVSRKHFALERGCRLRGLSPGNYSV-RVRATSLA-GNGSWTEPTYFYVTDYLDVPSNIAKIII 961

  Fly  2119 SPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMA 2183
            .|      ::.:...:.::.|..|.|      :||        |...|           ...|.|
Mouse   962 GP------LIFVFLFSVVIGSIYLFL------RKR--------QPDGP-----------MGPLYA 995

  Fly  2184 VRNRAFSTTLSDADI----ALLPQINW----SQLKLLRFLGSGAFGEVYEGQLK-TEDSEEPQRV 2239
            ..|..:   ||.:|:    ..:|. .|    .::.|||.||.|:||.||||..| ....|...||
Mouse   996 SSNPEY---LSASDVFPSSVYVPD-EWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRV 1056

  Fly  2240 AIKSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAAR 2302
            |:|::.:.||  |..|.|.||.:|..|...::|.|:|:....:...::||.|..|||.|:||:.|
Mouse  1057 AVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLR 1121

  Fly  2303 ATSTQ---EPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTV 2364
            ..:..   .|.||    |.|::.|..::|:|.:||....|||||||.|||:|....       ||
Mouse  1122 PDAENNPGRPPPT----LQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDF-------TV 1175

  Fly  2365 KIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYA 2429
            ||||||:.||||::|||||.|:|||||||||||||.||:||..||:|:|||:.|||.:|.:|||.
Mouse  1176 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQ 1240

  Fly  2430 ARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMA 2494
            ..:|.:||..|.:||.|..|..|.|:|..|:.:||:.:|..||:|....|.|   ..||      
Mouse  1241 GLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLL---KDDL------ 1296

  Fly  2495 SATADTVVSCSRPEF-KVRFDGQPLEEHREHNERPEDENL-----TLREVPL------KDKQLYA 2547
                       .|.| :|.|      .:.|.|:.||.|.|     .:..|||      :.::...
Mouse  1297 -----------HPSFPEVSF------FYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGG 1344

  Fly  2548 NEGVSRL 2554
            .||.|.|
Mouse  1345 REGGSSL 1351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 15/97 (15%)
FN3 1993..2111 CDD:238020 24/138 (17%)
Pkinase_Tyr 2209..2481 CDD:285015 128/277 (46%)
PTKc_c-ros 2213..2483 CDD:270640 127/275 (46%)
InsrNP_001316985.1 Recep_L_domain 52..164 CDD:279382
Furin-like 179..337 CDD:279142
FU 234..281 CDD:238021
Recep_L_domain 359..472 CDD:279382 22/114 (19%)
FN3 624..>667 CDD:238020 9/63 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 688..709 3/20 (15%)
Insulin-binding. /evidence=ECO:0000250 735..743 0/7 (0%)
FN3 869..946 CDD:238020 21/109 (19%)
Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250 998..1001 1/2 (50%)
PTKc_InsR 1018..1305 CDD:133192 135/317 (43%)
Pkinase_Tyr 1025..1292 CDD:285015 128/277 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1361..1384
PIK3R1 binding. /evidence=ECO:0000250 1363..1366
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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