DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and MAMDC4

DIOPT Version :9

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_996803.2 Gene:MAMDC4 / 158056 HGNCID:24083 Length:1137 Species:Homo sapiens


Alignment Length:1368 Identity:267/1368 - (19%)
Similarity:372/1368 - (27%) Gaps:572/1368 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   825 GGKPHSLKAL-------------LGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAF 876
            |..|||...|             .|.:|:..:.:.|......|:...|.| |.....|||     
Human    96 GPGPHSDHTLGTDLGWYMAVGTHRGKEASTAALRSPTLREAASSCKLRLW-YHAASGDVA----- 154

  Fly   877 SIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWPLGP---------HRLRWA 932
                                 :|||...:     |..|..|...|.|.||         .|:|..
Human   155 ---------------------ELRVELTH-----GAETLTLWQSTGPWGPGWQELAVTTGRIRGD 193

  Fly   933 SRQGSVIHTNELGEGLEVQQEQLE----RLPGPMTMVNESVGYYVTGDGLLHCIN--LVHSQWGC 991
            .|.......|....| .|..:.||    .||.|  ..|...|::       ||.|  .|..|..|
Human   194 FRVTFSATRNATHRG-AVALDDLEFWDCGLPTP--QANCPPGHH-------HCQNKVCVEPQQLC 248

  Fly   992 -------PISE--PLQHVGSVTYDWRGGRVYWTDLARNCVVRMDPWS-----GSRELLPVF---- 1038
                   .:|:  ||.....:..|:..|...|.        |.:.||     |..| .|.:    
Human   249 DGEDNCGDLSDENPLTCGRHIATDFETGLGPWN--------RSEGWSRNHRAGGPE-RPSWPRRD 304

  Fly  1039 ------EANFLALDPRQGHLYYATSSQLSRHGSTPDEAVTYYRVNGLEGSIASFVLDTQQDQLFW 1097
                  :.:||......|.....:|.:....|::....|.|..::|.|....         |||.
Human   305 HSRNSAQGSFLVSVAEPGTPAILSSPEFQASGTSNCSLVFYQYLSGSEAGCL---------QLFL 360

  Fly  1098 LVKGSGALRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERSGRRARL-VRLA 1161
            ...|.||   .|||:        ::::.:|             .||. .|:     |.|: ::.|
Human   361 QTLGPGA---PRAPV--------LLRRRRG-------------ELGT-AWV-----RDRVDIQSA 395

  Fly  1162 APLDVM--------------ELPTPDQASPASALQLLDPQPLPPRDEGVIPMTVLPDSVRLDD-- 1210
            .|..::              :|...|...|.|.:..|  |||||......|.. ||.|.||.|  
Human   396 YPFQILLAGQTGPGGVVGLDDLILSDHCRPVSEVSTL--QPLPPGPRAPAPQP-LPPSSRLQDSC 457

  Fly  1211 --GHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQRLQTLDLSTPFARLTQLPQAQLQLKISITPRT 1273
              ||                              |...||..|                      
Human   458 KQGH------------------------------LACGDLCVP---------------------- 470

  Fly  1274 AWRSGDTTRVQLTTPPVAPSQPRRLRVFVERLATALQEANVSAVLRWDAPEQG--QEAPMQALEY 1336
                                 |.:|..|.|:.|.. ::........:::||.|  ::|.:..|: 
Human   471 ---------------------PEQLCDFEEQCAGG-EDEQACGTTDFESPEAGGWEDASVGRLQ- 512

  Fly  1337 HISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQV--EARVAATGAAAGAASHALHVAPEVQ 1399
                |......|    :|.:..|...|....|....|:  ||||..........|..||:|..:|
Human   513 ----WRRVSAQE----SQGSSAAAAGHFLSLQRAWGQLGAEARVLTPLLGPSGPSCELHLAYYLQ 569

  Fly  1400 AVPRVLYANAE------FIGELDLDTRNRRRLVHTASPVEHLVGIEGEQRLLWVNEHVELLTHVP 1458
            :.||.:..|.|      :.|.|. ||..|                       ||........|..
Human   570 SQPREVSCNFERDTCSWYPGHLS-DTHWR-----------------------WVESRGPDHDHTT 610

  Fly  1459 GSAPAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRG 1523
            |..                       ::..||.|.|.|                     |.....
Human   611 GQG-----------------------HFVLLDPTDPLA---------------------WGHSAH 631

  Fly  1524 RLLKDLV-ALPQAQSLIWLEYEQGSPRNGSLR-------------GRNLTDGSELE--WATVQPL 1572
            .|.:..| |.|......|  |....|:.|:||             .|:.|.|:...  |||:   
Human   632 LLSRPQVPAAPTECLSFW--YHLHGPQIGTLRLAMRREGEETHLWSRSGTQGNRWHEAWATL--- 691

  Fly  1573 IRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGE---DSIAGQLAQDSGYL 1634
                  |.:|||                           .||..||.|   |...|.:|.|...:
Human   692 ------SHQPGS---------------------------HAQYQLLFEGLRDGYHGTMALDDVAV 723

  Fly  1635 YAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLK-------- 1691
            .....|                           |.||.::...:|...|...|...:        
Human   724 RPGPCW---------------------------APNYCSFEDSDCGFSPGGQGLWRRQANASGHA 761

  Fly  1692 ----ATDCEEQRCLLHLPMITASEDCPLPIPGVRYQ-LNLTLAKEPGSEEHDHGMEPLGQWLLGA 1751
                .||...:....|..::..|.|. ||    |.| .:||      |:||    .||.|     
Human   762 AWGPPTDHTTETAQGHYMVVDTSPDA-LP----RGQTASLT------SKEH----RPLAQ----- 806

  Fly  1752 GESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELE 1816
                             ...|:.:|...|..|..:...||          .|.            
Human   807 -----------------PACLTFWYHGSLRSPGTLRVYLE----------ERG------------ 832

  Fly  1817 VSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGI-----------K 1870
                 ..|:.|.|.:..|.|:  |...:||..|.|......:.....|....:           :
Human   833 -----RHQVLSLSAHGGLAWR--LGSMDVQAERAWRVVFEAVAAGVAHSYVALDDLLLQDGPCPQ 890

  Fly  1871 PGS-------------------GYSLWVQAHATPTKSNSSERLHVRSFAELPELQLL--ELGPYS 1914
            |||                   |||......|||::           :.:.|....|  |.|.::
Human   891 PGSCDFESGLCGWSHLAWPGLGGYSWDWGGGATPSR-----------YPQPPVDHTLGTEAGHFA 944

  Fly  1915 LSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAP-- 1977
            ...|  |...|.|        .|..||.           ||| |.|...|   |.:....|.|  
Human   945 FFET--GVLGPGG--------RAAWLRS-----------EPL-PATPASC---LRFWYHMGFPEH 984

  Fly  1978 --------LYH---GTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNG---APIALYNL 2028
                    |.|   |...|:...|....|..:.|:|..:.:.|::.:.|..|..   .||||.::
Human   985 FYKGELKVLLHSAQGQLAVWGAGGHRRHQWLEAQVEVASAKEFQIVFEATLGGQPALGPIALDDV 1049

  Fly  2029 EAL 2031
            |.|
Human  1050 EYL 1052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020 20/107 (19%)
LY 993..1026 CDD:214531 7/34 (21%)
FN3 1292..1374 CDD:214495 16/83 (19%)
FN3 1799..1897 CDD:238020 21/127 (17%)
FN3 1993..2111 CDD:238020 12/42 (29%)
Pkinase_Tyr 2209..2481 CDD:285015
PTKc_c-ros 2213..2483 CDD:270640
MAMDC4NP_996803.2 MAM 63..219 CDD:214533 33/155 (21%)
MAM 66..219 CDD:99706 33/155 (21%)
LDLa 229..261 CDD:238060 8/38 (21%)
MAM 271..425 CDD:279023 37/201 (18%)
MAM 272..422 CDD:99706 36/197 (18%)
LDLa 457..490 CDD:238060 11/106 (10%)
MAM 577..729 CDD:279023 46/257 (18%)
MAM 577..728 CDD:99706 46/256 (18%)
MAM 734..890 CDD:279023 38/221 (17%)
MAM 734..888 CDD:99706 38/219 (17%)
MAM 889..1055 CDD:214533 46/200 (23%)
MAM 894..1055 CDD:99706 43/195 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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