DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sev and Fgfr4

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:XP_006517162.3 Gene:Fgfr4 / 14186 MGIID:95525 Length:829 Species:Mus musculus


Alignment Length:947 Identity:240/947 - (25%)
Similarity:366/947 - (38%) Gaps:254/947 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1667 QAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKE 1731
            |||.| .|..|..|.|..:...|    .|.            |||.|..||...:.|:......:
Mouse    31 QAHTY-LYVYKRGLALQGTEPGL----GCR------------ASEPCLAPILEQQEQVLTVALGQ 78

  Fly  1732 P-----GSEEHDHGMEPLGQWLLGAGE------SLNLTDLLP--FTRYRVSGILSSFYQKKLALP 1783
            |     |..|........|..|..||.      .|.:...||  ..||     |.........:.
Mouse    79 PVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRY-----LCLARGSMTVVH 138

  Fly  1784 TLVLAPLELLTASATPSPPRNFSVRV---LSPRELEVSWLPPEQLRSE--------SVYY----- 1832
            .|.|...:.||:.:....|:..|...   :.|::... |..|:::..:        :|.:     
Mouse   139 NLTLLMDDSLTSISNDEDPKTLSSSSSGHVYPQQAPY-WTHPQRMEKKLHAVPAGNTVKFRCPAA 202

  Fly  1833 -----TLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSE 1892
                 |:||.:  ||:...               |.:|:.||:....:...|.....|:...:..
Mouse   203 GNPMPTIHWLK--DGQAFH---------------GENRIGGIRLRHQHWSLVMESVVPSDRGTYT 250

  Fly  1893 RLHVRSFAELPE---LQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVE 1954
            .|...|...:..   |.:||..|:.          |:....|...::|      |.|:..:::  
Mouse   251 CLVENSLGSIRYSYLLDVLERSPHR----------PILQAGLPANTTA------VVGSDVELL-- 297

  Fly  1955 PLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGN 2019
                     |:                   ||     :.:||....|:|:.     :..::...:
Mouse   298 ---------CK-------------------VY-----SDAQPHIQWLKHVV-----INGSSFGAD 324

  Fly  2020 GAP---------IALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTT 2075
            |.|         |....:|.|..|:                          |..||       ..
Mouse   325 GFPYVQVLKTTDINSSEVEVLYLRN--------------------------VSAED-------AG 356

  Fly  2076 ELSCIV-KSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKR---------GSLVLAI 2130
            |.:|:. .|:           ..|.:..|.....| |.:.....:||.|         |||||.:
Mouse   357 EYTCLAGNSI-----------GLSYQSAWLTVLPE-EDLTWTTATPEARYTDIILYVSGSLVLLV 409

  Fly  2131 IAPAAIVSSCVLALVLVRKV------------QK--RRLRAKKLLQQSRPSIWSNLSTLQTQQQL 2181
            :        .:||.|..|:|            ||  |...|::...:||.|..|:||.::..:  
Mouse   410 L--------LLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVR-- 464

  Fly  2182 MAVRNRAFSTTLSDADIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQR---V 2239
            ::.......|.|.:.|:.|.|.  |    .:|.|.:.||.|.||:|...:....|...|.:   |
Mouse   465 LSSSGPPLLTGLVNLDLPLDPL--WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTV 527

  Fly  2240 AIKSLRKGAS--EFAELLQEAQLMSNF-KHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAA 2301
            |:|.|:..||  :.|:|:.|.::|... :|:||:.|:|:|.....:.:|:|....|:|..:|||.
Mouse   528 AVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRAR 592

  Fly  2302 RA----TSTQEPQPTAG-LSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRR 2361
            |.    .|...|:.:.| ||...|::....||.|..|||....:|||||.||.||||..      
Mouse   593 RPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDD------ 651

  Fly  2362 RTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQ 2426
             .:||.||||||.::..|||:|...|.|||:||:||:|.|.::|.|||||:||:|.|||.|||..
Mouse   652 -VMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGS 715

  Fly  2427 PYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLH----AIS-- 2485
            ||......|:.:.::||.|:::||.|..:||.|:..||...|.:||:|::....|.    |:|  
Mouse   716 PYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 780

  Fly  2486 -TDLRRT--QMASATADTVVSCSRPEFKVRFDGQPLE 2519
             .|||.|  ..:.:..|...:||..:.....|..|||
Mouse   781 YLDLRLTFGPFSPSNGDASSTCSSSDSVFSHDPLPLE 817

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 17/111 (15%)
FN3 1993..2111 CDD:238020 19/127 (15%)
PTKc_c-ros 2213..2483 CDD:270640 111/284 (39%)
Fgfr4XP_006517162.3 IG_like 70..143 CDD:214653 15/77 (19%)
Ig strand B 80..84 CDD:409353 0/3 (0%)
Ig strand E 111..115 CDD:409353 1/3 (33%)
Ig strand F 125..130 CDD:409353 3/9 (33%)
Ig 174..268 CDD:472250 17/111 (15%)
Ig strand B 195..199 CDD:409353 1/3 (33%)
Ig strand C 208..212 CDD:409353 2/3 (67%)
Ig strand E 234..238 CDD:409353 0/3 (0%)
Ig strand F 248..253 CDD:409353 0/4 (0%)
Ig strand G 261..264 CDD:409353 0/2 (0%)
Ig 276..378 CDD:472250 26/191 (14%)
Ig strand B 294..298 CDD:409353 0/14 (0%)
Ig strand C 307..311 CDD:409353 0/3 (0%)
Ig strand E 343..347 CDD:409353 2/3 (67%)
Ig strand F 357..362 CDD:409353 2/4 (50%)
Ig strand G 370..373 CDD:409353 0/2 (0%)
PTKc_FGFR4 481..794 CDD:133230 122/321 (38%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.