DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and Fgfr3

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_001156689.1 Gene:Fgfr3 / 14184 MGIID:95524 Length:802 Species:Mus musculus


Alignment Length:859 Identity:210/859 - (24%)
Similarity:347/859 - (40%) Gaps:216/859 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1718 PGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESLNLTDLLPF---TRYRV-----SGILSS 1774
            ||...::....|:.||.|....     .|...|:|:::.|:...|.   |...|     :|:::|
Mouse    23 PGPEQRVVRRAAEVPGPEPSQQ-----EQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVAS 82

  Fly  1775 FYQKKLALPTLVLAP--LELLTAS------------ATPSPPRNFSVRVLSPREL-------EVS 1818
            .        .:::.|  |::|.||            .|.....:|||||......       :|:
Mouse    83 H--------RILVGPQRLQVLNASHEDAGVYSCQHRLTRRVLCHFSVRVTDAPSSGDDEDGEDVA 139

  Fly  1819 -------WLPPEQLRSESVYY----TLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPG 1872
                   |..||::..:.:..    |:.::....| |......|..:.:  |..|.||:.|||  
Mouse   140 EDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG-NPTPSISWLKNGK--EFRGEHRIGGIK-- 199

  Fly  1873 SGYSLW--VQAHATPTKSNSSERLHVRSFAELPE---LQLLELGPYSLSLTWAGTPDPLGSLQLE 1932
            ..:..|  |.....|:...:...:....|..:.:   |.:||..|:. .:..||.|         
Mouse   200 LRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHR-PILQAGLP--------- 254

  Fly  1933 CRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPG 1997
                         .|.|.::...::    :.|:                   ||     :.:||.
Mouse   255 -------------ANQTAILGSDVE----FHCK-------------------VY-----SDAQPH 278

  Fly  1998 KPQLEHIAEEVFRVTWTAARGNGAPIALY-------NLEALQARSDIRRRRRRRRRNSGGSLEQL 2055
            ...|:|:     .|..:....:|.|....       |:||     |.|.|........||..   
Mouse   279 IQWLKHV-----EVNGSKVGPDGTPYVTVLKSWISENVEA-----DARLRLANVSERDGGEY--- 330

  Fly  2056 PWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSP 2120
                           .|..|....:.:.       .|.:|..      ||.:.|.|     .:..
Mouse   331 ---------------LCRATNFIGVAEK-------AFWLRVH------GPQAAEEE-----LMET 362

  Fly  2121 EKRGSLVLAIIAPAAIVSSCVLALVLV-----RKVQKRRLRAKKLLQQSR------PSIWSNLST 2174
            ::.||:...:::...:....:|.:..|     |...|:.|.:..:.:.||      .|:.|| |:
Mouse   363 DEAGSVYAGVLSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESN-SS 426

  Fly  2175 LQTQQQLMAVRNRAFS-----TTLSDADIALLP--QINWSQLKLLRFLGSGAFGEVYEGQ---LK 2229
            :.:...|:.:...:..     ..:|:.::...|  :::.::|.|.:.||.|.||:|...:   :.
Mouse   427 MNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGID 491

  Fly  2230 TEDSEEPQRVAIKSLRKGAS--EFAELLQEAQLMSNF-KHENIVCLVGICFDTESISLIMEHMEA 2291
            .:.:.:|..||:|.|:..|:  :.::|:.|.::|... ||:||:.|:|.|.....:.:::|:...
Mouse   492 KDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 556

  Fly  2292 GDLLSYLRAAR---------ATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACR 2347
            |:|..:|||.|         |....|.|    |:..:|::....||.|..||.....:|||||.|
Mouse   557 GNLREFLRARRPPGMDYSFDACRLPEEQ----LTCKDLVSCAYQVARGMEYLASQKCIHRDLAAR 617

  Fly  2348 NCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWA 2412
            |.||||.       ..:||.|||||||::..|||:|...|.|||:||:||:|.|.::|.|||||:
Mouse   618 NVLVTED-------NVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 675

  Fly  2413 FGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRC 2477
            ||||.|||.|||..||......|:...:|||.|:.:|..||..||.::..||...|.:||:|::.
Mouse   676 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQL 740

  Fly  2478 YNTLHAI----STD 2487
            ...|..|    |||
Mouse   741 VEDLDRILTVTSTD 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996 23/110 (21%)
FN3 1993..2111 CDD:238020 22/124 (18%)
PTKc_c-ros 2213..2483 CDD:270640 108/284 (38%)
Fgfr3NP_001156689.1 ig 46..110 CDD:395002 14/71 (20%)
Ig strand B 55..59 CDD:409353 1/3 (33%)
Ig strand C 69..73 CDD:409353 1/3 (33%)
Ig strand E 91..94 CDD:409353 1/2 (50%)
Ig strand F 104..108 CDD:409353 0/3 (0%)
IgI_2_FGFR 145..239 CDD:409443 19/98 (19%)
Ig strand A 145..148 CDD:409443 0/2 (0%)
Ig strand A' 156..161 CDD:409443 0/4 (0%)
Ig strand B 165..173 CDD:409443 1/7 (14%)
Ig strand C 179..184 CDD:409443 1/4 (25%)
Ig strand C' 187..189 CDD:409443 0/3 (0%)
Ig strand D 198..201 CDD:409443 2/4 (50%)
Ig strand E 205..210 CDD:409443 2/4 (50%)
Ig strand F 219..226 CDD:409443 0/6 (0%)
Ig strand G 229..239 CDD:409443 1/9 (11%)
IgI_3_FGFR 247..347 CDD:409363 26/184 (14%)
Ig strand A 247..250 CDD:409363 0/2 (0%)
Ig strand A' 254..258 CDD:409363 2/25 (8%)
Ig strand B 266..273 CDD:409363 3/34 (9%)
Ig strand C 277..284 CDD:409363 2/6 (33%)
Ig strand D 299..304 CDD:409363 0/4 (0%)
Ig strand E 315..320 CDD:409363 2/4 (50%)
Ig strand F 328..336 CDD:409363 2/25 (8%)
Ig strand G 339..347 CDD:409363 1/14 (7%)
PTKc_FGFR3 455..788 CDD:173652 115/311 (37%)
Blue background indicates that the domain is not in the aligned region.

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