Protein Alignment sev and Fes

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_034324.2
• Gene: Fes / 14159
• MGIID: 95514
• Length: 822
• Species: Mus musculus
• Alignment Length: 1075
• Identity: 255/1075 - (23%)
• Similarity: 397/1075 - (36%)
• Gaps: 356/1075 - (33%)

  Fly  1503 DLCNFEG------------KILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRG 1555
            :||:.:|            ::|:|.|.|...|.:..::...|....||    .:.|        |
Mouse     6 ELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSL----QDSG--------G 58

  Fly  1556 RNLTDGSE----LEWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQLCTASALRAQLN 1616
            ::.:.|.:    ..||.:.             |:|.||                  :..||..
Mouse    59 QSWSSGPDSPVSQSWAEIT-------------SQTENL------------------SRVLRQH-- 90

  Fly  1617 LLGEDSIAGQLAQDSGYLYAVKNWSIRAYGRRRQQLE--------YTVELEPEEVRLLQAHNYQA 1673
              .||..:|.|::.| .|...:....:.|..:.|||:        ..:|....:.|.|...:.||
Mouse    91 --AEDLNSGPLSKLS-VLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQA 152

  Fly  1674 ---YPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSE 1735
               |          ...|..|..|..:.:.:..|..:.|..:        ||.|.:..|:   ..
Mouse   153 RRKY----------QEASKDKDRDKAKDKYVRSLWKLFAHHN--------RYVLGVRAAQ---LH 196

  Fly  1736 EHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLV---LAPL--ELLTA 1795
            .|.|     .:::| .|...:|.||    ...::|||....|:.|.:.:||   :|.:  ||..|
Mouse   197 HHHH-----HRFML-PGLLQSLQDL----HEEMAGILKDILQEYLEISSLVQDDVASIHRELAAA 251

  Fly  1796 SATPSPPRNFSVRVLSPRELEVSWL------------PPEQLRSESVYYTLHWQQELDGENVQDR 1848
            :|...|              |..:|            ||.....||:..        |||.
Mouse   252 AARIQP--------------EFEYLGFLRQYGSTPDVPPCVTFDESLLE--------DGEQ---- 290

  Fly  1849 REWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPY 1913
                                ::||                               ||||.||...
Mouse   291 --------------------LEPG-------------------------------ELQLNELTLE 304

  Fly  1914 SLSLTWAGTPDPLGSLQLECRSSAE---QLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPG 1975
            |:..|.....|.|.....|..|..|   ||:|.:....     :...||.|.|   ||
Mouse   305 SVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEE-----QNTHPRERVQ---LL------- 354

  Fly  1976 APLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRR 2040
                                 .|.|:  :.|.:          .|..|||.:.:.|||:.::.:.
Mouse   355 ---------------------SKRQM--LQEAI----------QGLQIALCSQDKLQAQQELLQS 386

  Fly  2041 RRRRRRNSGGSLEQLPWAEEPVV--VEDQWLDFCNT--------TELSCIVKSLHSSRL------ 2089
            :          :|||...|.|.|  ::|......:|        |....|:|| |.|.:
Mouse   387 K----------MEQLGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKS-HFSGIFRPKFS 440

  Fly  2090 ------LLFRVRARSLE----HGWGPYSEESERVAE--PFVSPEKRG--SLVLAIIAPAAIVSSC 2140
                  |:..|:....|    ||..|.:|.:|.:..  .|:..|.:|  ..||:::...
Mouse   441 IPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDG------ 499

  Fly  2141 VLALVLVRKVQKRRLRAKKLLQQSR----------PSIWSNLSTLQTQQQLMAVRNRAFSTTLSD 2195
                      |.|..    ::|.|.          |||...::.|.:.||.:..::   ...|..
Mouse   500 ----------QPRHF----IIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKS---GVVLFR 547

  Fly  2196 ADIALLPQINW----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASE--FAEL 2254
            |    :|:..|    ..|.|...:|.|.||||:.|:|:.:::.    ||:||.|:....  .|:.
Mouse   548 A----VPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTP----VAVKSCRETLPPDLKAKF 604

  Fly  2255 LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSE 2319
            ||||:::..:.|.|||.|:|:|...:.|.::||.::.||.|::||...|.          |.:..
Mouse   605 LQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR----------LRVKT 659

  Fly  2320 LLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKE 2384
            ||.|..|.|.|..|||....:|||||.|||||||       :..:||.|||::|:.....|....
Mouse   660 LLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE-------KNVLKISDFGMSREEADGIYAASA 717

  Fly  2385 GEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQP 2449
            |...:||:|.:||:|..|.::::||||:||:|.||..:||..||....|.:....|::|.||..|
Mouse   718 GLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCP 782

  Fly  2450 PMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI 2484
            .:|.:.::.|:..||..:|.:||||......||:|
Mouse   783 ELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSI 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	12/102 (12%)
		FN3	1993..2111	CDD:238020	31/143 (22%)
		PTKc_c-ros	2213..2483	CDD:270640	100/271 (37%)
Fes	NP_034324.2	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		82/449 (18%)
		F-BAR_Fes	7..239	CDD:153369	61/310 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..420		5/27 (19%)
		SH2_Fps_family	453..537	CDD:198224	21/103 (20%)
		Protein Kinases, catalytic domain	564..814	CDD:473864	99/270 (37%)