DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and Csk

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_031809.2 Gene:Csk / 12988 MGIID:88537 Length:450 Species:Mus musculus


Alignment Length:536 Identity:139/536 - (25%)
Similarity:216/536 - (40%) Gaps:138/536 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1979 YHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRV-------TWTAARGNGAPIALYNLEALQARSD 2036
            :|||||     .|.|...|         :|..:       .|..|:.......:.....:|.|..
Mouse    20 FHGTAE-----QDLPFCKG---------DVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG 70

  Fly  2037 IRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKSLHSSRLL------LFRVR 2095
            ::         :|..|..:||....:..|                   .:.|||      ||.||
Mouse    71 VK---------AGTKLSLMPWFHGKITRE-------------------QAERLLYPPETGLFLVR 107

  Fly  2096 ARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKL 2160
            .                      |....|...|.:        ||      ..||:..|:    :
Mouse   108 E----------------------STNYPGDYTLCV--------SC------EGKVEHYRI----M 132

  Fly  2161 LQQSRPSI-----WSNLSTLQTQQQLMA--VRNRAFSTTLSDADIALLPQ-------INWSQLKL 2211
            ...|:.||     :.||..|.......|  :..|.....:.:..:|...:       :|..:|||
Mouse   133 YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKL 197

  Fly  2212 LRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGIC 2276
            |:.:|.|.||:|..|..:      ..:||:|.::..|:..| .|.||.:|:..:|.|:|.|:|:.
Mouse   198 LQTIGKGEFGDVMLGDYR------GNKVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQLLGVI 255

  Fly  2277 FDTE-SISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFV 2340
            .:.: .:.::.|:|..|.|:.||| :|..|.        |....||...:||.....|||..:||
Mouse   256 VEEKGGLYIVTEYMAKGSLVDYLR-SRGRSV--------LGGDCLLKFSLDVCEAMEYLEGNNFV 311

  Fly  2341 HRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFT 2405
            |||||.||.||:|.       ...|:.||||.::...:     :..|.|||:|.:||:|.:..|:
Mouse   312 HRDLAARNVLVSED-------NVAKVSDFGLTKEASST-----QDTGKLPVKWTAPEALREKKFS 364

  Fly  2406 TQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWE 2470
            |:||||:||:|.|||.:.|:.||......:|:..|::|.::..|..|...:|.::..||..|...
Mouse   365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAT 429

  Fly  2471 RPSFRRCYNTLHAIST 2486
            ||:|.:....|..|.|
Mouse   430 RPTFLQLREQLEHIKT 445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020 19/130 (15%)
PTKc_c-ros 2213..2483 CDD:270640 90/270 (33%)
CskNP_031809.2 Interaction with PTPN22. /evidence=ECO:0000269|PubMed:8890164 9..70 13/63 (21%)
SH3_CSK 11..67 CDD:212703 11/60 (18%)
SH2_csk_like 78..175 CDD:198190 26/155 (17%)
PTKc_Csk 188..443 CDD:133213 95/282 (34%)
Blue background indicates that the domain is not in the aligned region.

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