Protein Alignment sev and Csk

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_061501935.1
• Gene: Csk / 1278803
• VectorBaseID: AGAMI1_000696
• Length: 1254
• Species: Anopheles gambiae
• Alignment Length: 1185
• Identity: 250/1185 - (21%)
• Similarity: 384/1185 - (32%)
• Gaps: 375/1185 - (31%)

  Fly  1574 RLHAGSLEP---GSETLNLVDNQGKLCVYDVARQLCTASALRAQLNLLGEDSIA--------GQL 1627
            |...|.|.|   |...||     .|..||: :::..|:|.|..|..   :.|||        |..
Mosquito   155 RSSGGGLLPNGGGKSMLN-----HKFIVYN-SKKPKTSSVLHQQYY---QQSIAAAAANGELGSS 210

  Fly  1628 AQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEV--------------RLLQAHNYQAYPPKN 1678
            ...|..|....::....|.|.|..|..:|...|..:              ||.|....|.:....
Mosquito   211 GSGSPPLPYPSHYQQYLYNRLRPSLSTSVLSSPSLITAAAIPSCSPPDRDRLEQQQQQQQHQLYQ 275

  Fly  1679 CLLLPSSGGSLL-----------KATDC---------EEQRCLLHLPMI---------------T 1708
            ..|......|||           |:|.|         ...|.:...|::               :
Mosquito   276 NSLFHQQHRSLLGTPPAAVPGWAKSTSCLVSSSAAAASSYRTVTASPLLLLPAQPARSAPQPYPS 340

  Fly  1709 ASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRV----S 1769
            |....|.|:|.  ...|.:|:..|.|  ...|..|..    ||..|.| |...|.....|    :
Mosquito   341 AGGTAPRPVPA--SSSNSSLSSSPSS--FSAGSPPSS----GANSSSN-TPPPPVVPSEVTATSA 396

  Fly  1770 GILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPR------------ELEVSWLP- 1821
            ..:::......:.||.........:.|.||.||.. :|...:|.            :::||.:|
Mosquito   397 NAVTATSTTTCSSPTTPTTTSPDASNSPTPVPPTG-TVAPSTPTHPSSPSSSTSNLDVDVSGVPR 460

  Fly  1822 --------PEQLRSESVYYTLHWQQEL---------DGENVQDRREWEAHE------RRLETAGT 1863
                    ...:.|:......|.||:.         ..|:|.|.|:.|..|      ||..|..:
Mosquito   461 FDRSTKPASSVIGSDQYQKRFHHQQQQPQQRSFDLPHSESVCDHRQQEEAEDSSLVARRNSTGSS 525

  Fly  1864 HRLTGIK----------PGSGYSL-----------------------------WVQAHATPTKSN 1889
            ..|.|:.          ||:|.:.                             |...|..|....
Mosquito   526 VALNGMNSHTAAINLQHPGTGQTAVVGHHRGFSSTVVAAANSAAASASATDCPWFLPHQMPPPPT 590

  Fly  1890 SSERLHVR--------------------------------SFAELPELQLL-------------- 1908
            :..|.|.|                                |....|:.|..
Mosquito   591 APARQHKRPAPQPGGATVVGGGGGGGGGGPGNHMQPPQFISPPPAPQQQQQQQQHQQQHSQQSAI 655

  Fly  1909 ----ELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLG 1969
                :|.|:|::.:.:....|:  .||....||:|....          .|:.|....|..:
Mosquito   656 VPPPQLPPHSVNPSLSSIHHPV--QQLVAPQSAQQQPHQ----------PPIPPHPAVQHHI--- 705

  Fly  1970 YAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEH------------IAEEVFRVTWTAARGNGAP 2022
                |.:|..|           .|.||....|:|            :.......|...:.|.|.|
Mosquito   706 ----PKSPNQH-----------HPPQPASAVLQHNPQAASAVGGGVLTNNSHHTTGPPSTGAGGP 755

  Fly  2023 -------IALYNLEALQARS-------------------DIRRRRRRRRRNS------------G 2049
                   .|..|:.:....|                   .|.::::::::.|            .
Mosquito   756 PVAPVTGSAAANMMSTSMNSAQLQGHILQPVGGLTGSALSIHQQQQQQQQQSAMVQGNQPVHHMS 820

  Fly  2050 GSLE---QLPWAEEPVVVED----------QWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEH 2101
            .||.   .||....|....|          .|  .|....||....|..::......|.|:....
Mosquito   821 NSLHGPIGLPTVVVPPAGHDGSNGVGGPAPGW--NCVPVGLSSPTTSAAAAAQRRAEVNAKLNAM 883

  Fly  2102 GW--GPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKKLLQQS 2164
            .|  |....|.   ||..:.|.:.|  :..:...........|.:....||:..|::
Mosquito   884 PWFHGRIKREE---AESLLKPREDG--LFLVRESTNFPGDYTLCVCFNEKVEHYRIK-------- 935

  Fly  2165 RPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDAD------IALLP--------------QINWSQL 2209
               ...|..|:...:....:.......|| |:|      :..||              :|....|
Mosquito   936 ---YVDNKLTIDDDEYFDHLGQLVEHYTL-DSDGLCTKLMKALPKEEFCVKDFQDNGWEIKMEDL 996

  Fly  2210 KLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVG 2274
            :|...:|.|.||:|..|.:|.|      :||:|.|:.......:.|.||.:|:..:|||:|..:|
Mosquito   997 QLKENIGKGEFGDVMLGIMKGE------KVAVKVLKDAGRASNKFLAEAGVMTTLEHENLVKFIG 1055

  Fly  2275 ICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHF 2339
            :.|..:.|.|:.|:|..|.|:.|||:         :....:|..:.:....|...|..|||....
Mosquito  1056 LVFHDKYIYLVTEYMSKGSLVDYLRS---------RGRQHISRKDQINFAYDTCCGMEYLETKKV 1111

  Fly  2340 VHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARD-IYKSDYYRKEGEGLLPVRWMSPESLVDGL 2403
            :|||||.||.|::|..       ..|:.||||||| .|..|      ...||::|.:||:|.:|.
Mosquito  1112 IHRDLAARNVLISEDC-------VAKVSDFGLARDERYTGD------SSKLPIKWTAPEALKEGK 1163

  Fly  2404 FTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDP 2468
            |:.::|:|:||:|.|||.:.|:.||......:|:.||..|.:::.|..|..::|.::...|...|
Mosquito  1164 FSNKTDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVGSGYKMEAPEGCPPEIYEMMRQAWDLVP 1228

  Fly  2469 WERPSF----RRCYN 2479
            .:||:|    ||.||
Mosquito  1229 EKRPTFAELKRRLYN 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	28/165 (17%)
		FN3	1993..2111	CDD:238020	30/182 (16%)
		PTKc_c-ros	2213..2483	CDD:270640	91/272 (33%)
Csk	XP_061501935.1	None