Protein Alignment sev and LOC1274321

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_061504086.1
• Gene: LOC1274321 / 1274321
• VectorBaseID: AGAMI1_010576
• Length: 1601
• Species: Anopheles gambiae
• Alignment Length: 819
• Identity: 206/819 - (25%)
• Similarity: 321/819 - (39%)
• Gaps: 238/819 - (29%)

  Fly  1794 TASATPSPPRNFSVRVLSPRELEVSWLPP--------EQLRSESVYYTLHWQQELDG--ENVQDR 1848
            |.||:||..|:.:.|           |||        ::.|..|.......||...|  :..|..
Mosquito   887 TDSASPSTDRSIAER-----------LPPGNSAAGRKKKKRKASKANRAARQQLSRGGPDGHQPE 940

  Fly  1849 REWEAHERRL----------------ETAGTHRLT---GIKPGSGYSLWVQA------HATPTKS 1888
            |....|.::.                :.:|..|.|   |:  |:.:|..|:|      |:|....
Mosquito   941 RHQPLHPQQAFSEDELLAEEQPALSPDHSGGPRATAAGGL--GTSFSQTVRATWRELIHSTNKVK 1003

  Fly  1889 NSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECR-SSAEQLRRNVAGNHTKMV 1952
            :||..|.:||.....:|.|:           |..||..|.|.:... |...:..:.|.|    |:
Mosquito  1004 DSSMNLALRSDRPEEKLDLI-----------AADPDRQGLLSIRFTFSDGGRKHQLVDG----MM 1053

  Fly  1953 VEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAAR 2017
            ...:.....|...||:  |.:....|..|:.       |...:|..|        ||     |.|
Mosquito  1054 ASDMHTTADYCVPLLV--ARSEDTQLQAGSP-------DGDMRPETP--------VF-----AQR 1096

  Fly  2018 GNGAPIALYNLEALQARSDIRRRRRR---RRRNSGGSLE----QLPWAEEPVVVEDQWLDFCNTT 2075
            .:.|..:|        :|::|.:..:   ::..||||::    .:..|:|          .|.|.
Mosquito  1097 ASKAGPSL--------KSNLRDKLTKLVHKKTASGGSVQSGGRSVATAQE----------VCRTC 1143

  Fly  2076 ELSCIVKS-------LHSSRLLL-FRVRARSL-------EHGWGPYSE----ESERVAEPFVSPE 2121
            ....:.:|       :|:||.:| ||.....:       :|..|..||    |.|.:....:.|.
Mosquito  1144 SKRIVQRSGSDGGGGMHASRTVLDFRKEFPDIDICEGGHDHLDGATSEMINLEYEDIDVLTIKPH 1208

  Fly  2122 KRGSLVLAIIAPAAIVSSCVLAL----------------VLVRKVQKRRLR-------------- 2156
            |       :|.|:|......:::                ||.|:...|.||
Mosquito  1209 K-------LIDPSAAEGGICVSMTLSTNRPLHEEEWFHGVLPREEVVRLLRNEGDFLVRETTRND 1266

  Fly  2157 ------------AKKLLQQSR------------PSIWSNLSTLQTQQQLMAVRNRAFST------ 2191
                        .|..:.|:.            ||| ..|...|.|.:| .|..|:.:.
Mosquito  1267 ESQTVLSVCWNGHKHFIVQTTAEGHYRFEGPAFPSI-QELIVHQYQSEL-PVTGRSGAVLRKPVL 1329

  Fly  2192 ----TLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASE-- 2250
                .||:.|:.||.:|           |.|.||:||:.:||   |.:...||:|:.|....|
Mosquito  1330 RERWELSNDDVILLDKI-----------GRGNFGDVYKAKLK---SSKNTLVAVKTCRMTLPEEQ 1380

  Fly  2251 FAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGL 2315
            ..:.|||.:::..:.|.|||.|:|||...:.|.::||.:..|.||.:||...:|          |
Mosquito  1381 KRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLRKNAST----------L 1435

  Fly  2316 SLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDY 2380
            ...:::.||.|.|.|..|||..:.:|||||.||||:    ||   ...|||.|||::|:  :.:|
Mosquito  1436 GQRQMMGMCRDAAAGMRYLESKNCIHRDLAARNCLI----GS---ENIVKISDFGMSRE--EEEY 1491

  Fly  2381 YRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGR 2445
            ....|...:|::|.:||:|..|.:|:..|||::|:|.|||.:.|..||:..:|......:.||.|
Mosquito  1492 IVSGGMKQIPIKWTAPEALNFGKYTSLCDVWSYGILVWEIFSRGDTPYSGMSNSMARERIDEGYR 1556

  Fly  2446 LQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAI 2484
            :..|.....::|.|:|.||..:|..||.|....:.:.|:
Mosquito  1557 MPAPEGAPPEMYRLMLKCWSYEPESRPHFDEICSVVDAL 1595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	24/125 (19%)
		FN3	1993..2111	CDD:238020	30/143 (21%)
		PTKc_c-ros	2213..2483	CDD:270640	95/271 (35%)
LOC1274321	XP_061504086.1	None