Protein Alignment sev and Alk

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_031465.2
• Gene: Alk / 11682
• MGIID: 103305
• Length: 1621
• Species: Mus musculus
• Alignment Length: 1516
• Identity: 352/1516 - (23%)
• Similarity: 535/1516 - (35%)
• Gaps: 531/1516 - (35%)

  Fly  1458 PGSAP-----AKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAIIYRLDLCNFEGKILQGERV 1517
            |.|.|     ..|:..|.:..:||||::            .|....:|..||      :|...|.
Mouse    32 PASGPPLQPREPLSYSRLQRKSLAVDFV------------VPSLFRVYARDL------LLPQPRS 78

  Fly  1518 WSTP-------RGRLLKD----LVALPQAQSLIWLE-YEQGSPRNGSLRGRNLTDGSELEWATVQ 1570
            .|.|       ||.|..|    |..|.....:.|.: ....||..|....|.|..||      |:
Mouse    79 PSEPEAGGLEARGSLALDCEPLLRLLGPLPGISWADGASSPSPEAGPTLSRVLKGGS------VR 137

  Fly  1571 PLIRLHAGSLEPGSETL-------------------NL--------VDNQGKLCV--------YD 1600
            .|.|.....||.|.||:                   ||        :..:|:|.:        .:
Mouse   138 KLRRAKQLVLELGEETILEGCIGPPEEVAAVGILQFNLSELFSWWILHGEGRLRIRLMPEKKASE 202

  Fly  1601 VARQLCTASALRA-QLNLLGEDSIAGQLAQDS--------GYLYAVKNWSIR----------AYG 1646
            |.|:...:||:|| |..||.:....|..:.:|        |.......|:::          .||
Mouse   203 VGREGRLSSAIRASQPRLLFQIFGTGHSSMESPSETPSPPGTFMWNLTWTMKDSFPFLSHRSRYG 267

  Fly  1647 RRRQ-----QLEYTVEL----------------EPEEVRLL---QAHNYQAYPPKNCLLLPSSGG 1687
            ....     :|||:..|                |...:.||   :|.:.|..|         .|.
Mouse   268 LECSFDFPCELEYSPPLHNHGNQSWSWRHVPSEEASRMNLLDGPEAEHSQEMP---------RGS 323

  Fly  1688 SLLKATDCEEQRCLLHLPMITASEDCPLPI-------PGVRYQLNLTLAKEPGSE------EHDH 1739
            .||..|..:.:..:|...|.::|:.|.|.:       |..||...|....|.|.|      ...|
Mouse   324 FLLLNTSADSKHTILSPWMRSSSDHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPTPGKH 388

  Fly  1740 GMEPLG--------------QWLLGAGESLNLTDLL-------------------PFTRYR---- 1767
            |...|.              :::.....||:..|..                   .||.:.
Mouse   389 GWTVLQGRVGRPANPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVL 453

  Fly  1768 ---------------------VSGILSSFY-----------QKKLA--LP--------------- 1783
                                 .|.:.:.||           |..|:  :|
Mouse   454 QLGQACDFHQDCAQGEDEGQLCSKLPAGFYCNFENGFCGWTQSPLSPHMPRWQVRTLRDAHSQGH 518

  Fly  1784 ---TLVLAPLELL-------TASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQ 1838
               .|:|:..::|       |::..|:|.:|      ||.||.:|||....||..   .:|...:
Mouse   519 QGRALLLSTTDILASEGATVTSATFPAPMKN------SPCELRMSWLIRGVLRGN---VSLVLVE 574

  Fly  1839 ELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQ----------------------- 1880
            ...|:. |.|..|.                :....|.|||..
Mouse   575 NKTGKE-QSRTVWH----------------VATDEGLSLWQHTVLSLLDVTDRFWLQIVTWWGPG 622

  Fly  1881 AHATPTKSNSS------------ERLHVRSFAELPELQ-LLELGPYSLSLTWA------------ 1920
            :.||....|.|            |::.:.|   :|:.: |.|..|...|.:||
Mouse   623 SRATVGFDNISISLDCYLTISGEEKMSLNS---VPKSRNLFEKNPNKESKSWANISGPTPIFDPT 684

  Fly  1921 --------GTPDPLGSLQLECRSSAEQLRRN-VAGNHTKMVVEPLQ-------PRT-RYQCRLLL 1968
                    |...|.|..|.:|.::.:....: |.|:.     .||:       |.| .|.   :.
Mouse   685 VHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVVVGSE-----GPLKGVQIWKVPATDTYS---IS 741

  Fly  1969 GYAATPG------APLYHGTA-------EVYETLGDAPSQPGKP------QL--------EHIAE 2006
            ||.|..|      ....||.:       |..:||.....|.|:.      ||        .::.|
Mouse   742 GYGAAGGKGGKNTMMRSHGVSVLGIFNLEKGDTLYILVGQQGEDACPRANQLIQKVCVGENNVIE 806

  Fly  2007 EVFRVT-----WTAARG------------NGAPIAL-----------------YNLEALQARSDI 2037
            |..||.     |....|            :|.|:.|                 ::.|.|::.|.:
Mouse   807 EEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTETFHPERLESNSSV 871

  Fly  2038 RRRRRRRRRNSGG----SLEQLPWA---------------------------------------- 2058
            ...........||    ....|.||
Mouse   872 LGLNGNSGAAGGGGGWNDNTSLLWAGKSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGG 936

  Fly  2059 -------------EEPVVVEDQWLDFCN------TTELS------------------CIVKSLH- 2085
                         .:|.:..:..:.|.:      |..|.                  |.|...|
Mouse   937 GGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHM 1001

  Fly  2086 ---SSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLV 2147
               |.:::.|      .:||.....:....:..|...|....||:|:::. :|:|::.|||...:
Mouse  1002 DPESHKVICF------CDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVT-SALVAALVLAFSGI 1059

  Fly  2148 RKVQKRRLRAKKLLQQSRPSIWSNLSTLQTQQQLMAVRNRAF---STTLSDADIALLPQINWSQL 2209
            ..|.:|:.:..:.:|....|....||.|:| ..:|...|..:   ..|.|.:|:..:|:.|   :
Mouse  1060 MIVYRRKHQELQAMQMELQSPEYKLSKLRT-STIMTDYNPNYCFAGKTSSISDLKEVPRKN---I 1120

  Fly  2210 KLLRFLGSGAFGEVYEGQLK-TEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVC 2271
            .|:|.||.||||||||||:. ..:...|.:||:|:|.:..||..||  |.||.::|.|.|:|||.
Mouse  1121 TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVR 1185

  Fly  2272 LVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLED 2336
            .:|:........:::|.|..|||.|:||..|   .:..|||: |::.:||.:..|:|.||.|||:
Mouse  1186 CIGVSLQALPRFILLELMAGGDLKSFLRETR---PRPNQPTS-LAMLDLLHVARDIACGCQYLEE 1246

  Fly  2337 MHFVHRDLACRNCLVT-ESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLV 2400
            .||:|||:|.||||:| ...|     |..||||||:|||||::.||||.|..:|||:||.||:.:
Mouse  1247 NHFIHRDIAARNCLLTCPGAG-----RIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFM 1306

  Fly  2401 DGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWR 2465
            :|:||:::|.|:||||.|||.:||..||.:::|.|||..|..|||:..|..|...:|.::..||:
Mouse  1307 EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQ 1371

  Fly  2466 TDPWERPSFRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPED 2530
            ..|.:||:|          :..|.|.:..:...|.:.:....|:     |..:||..:...||:|
Mouse  1372 HQPEDRPNF----------AIILERIEYCTQDPDVINTALPIEY-----GPVVEEEEKVPMRPKD 1421

  Fly  2531 EN----LTLREVPLKDKQLYA 2547
            ..    |.:...|.|.::..|
Mouse  1422 PEGMPPLLVSPQPAKHEEASA 1442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	23/113 (20%)
		FN3	1993..2111	CDD:238020	32/250 (13%)
		PTKc_c-ros	2213..2483	CDD:270640	123/273 (45%)
Alk	NP_031465.2	Heparin-binding region. /evidence=ECO:0000250|UniProtKB:Q9UM73	48..70		7/33 (21%)
		MAM	270..428	CDD:99706	32/166 (19%)
		LDLa	445..471	CDD:197566	2/25 (8%)
		MAM	484..639	CDD:459878	32/180 (18%)
		EGF-like. /evidence=ECO:0000250|UniProtKB:Q9UM73	991..1029		7/43 (16%)
		FXa_inhibition	991..1025	CDD:464251	7/39 (18%)
		PTKc_ALK_LTK	1113..1389	CDD:270632	128/297 (43%)
		PHA03247	<1374..1580	CDD:223021	18/84 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1412..1556		7/31 (23%)