DRSC/TRiP Functional Genomics Resources

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Protein Alignment sev and Abl2

DIOPT Version :10

Sequence 1:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster
Sequence 2:NP_033725.2 Gene:Abl2 / 11352 MGIID:87860 Length:1182 Species:Mus musculus


Alignment Length:521 Identity:144/521 - (27%)
Similarity:221/521 - (42%) Gaps:128/521 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  2098 SLE-HGW--GPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLRAKK 2159
            ||| |.|  ||.|..                      |...::||.:....|||:.:....:...
Mouse   167 SLEKHSWYHGPVSRS----------------------AAEYLLSSLINGSFLVRESESSPGQLSI 209

  Fly  2160 LLQQSRPSIWSNLSTLQTQQQLMAVRNRAFST---------TLSDADIALL----PQIN------ 2205
            .|:.........::| .|..::.......|||         |::|..:..|    |:.|      
Mouse   210 SLRYEGRVYHYRINT-TTDSKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYG 273

  Fly  2206 -------W----SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQ 2259
                   |    :.:.:...||.|.:||||.|..|    :....||:|:|::...|..|.|:||.
Mouse   274 VSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWK----KYSLTVAVKTLKEDTMEVEEFLKEAA 334

  Fly  2260 LMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMC 2324
            :|...||.|:|.|:|:|.......::.|:|..|:||.|||..   |.:|      ::...||.|.
Mouse   335 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC---SREE------VTAVVLLYMA 390

  Fly  2325 IDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLL 2389
            ..:::...|||..:|:|||||.|||||.|:       ..||:.||||:| :...|.|........
Mouse   391 TQISSAMEYLEKKNFIHRDLAARNCLVGEN-------HVVKVADFGLSR-LMTGDTYTAHAGAKF 447

  Fly  2390 PVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTE 2454
            |::|.:||||....|:.:|||||||||.|||.|.|..||...:..:|...:::|.|::||..|..
Mouse   448 PIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512

  Fly  2455 KLYSLLLLCWRTDPWERPSF---RRCYNTL-------HAISTDLRRTQMASA------------- 2496
            |:|.|:..||:..|.:||||   .:.:.|:       ..::.:|.||..:|:             
Mouse   513 KVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRTASSSSVVPYLPRLPLLPS 577

  Fly  2497 --------------------TADTVVSCSRPEFKVR----FDGQPLEEHREHNERP----EDENL 2533
                                .|:::.|.|.|...:|    ..|.|....::.::.|    ||...
Mouse   578 KTRTLRKQGENKENLDGGLDAAESLASSSAPAGFIRSTQASSGSPALPRKQRDKSPSSLLEDAKE 642

  Fly  2534 T 2534
            |
Mouse   643 T 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sevNP_511114.2 fn3 439..520 CDD:394996
FN3 826..921 CDD:238020
Vgb 992..>1118 CDD:443399
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
fn3 1800..1891 CDD:394996
FN3 1993..2111 CDD:238020 8/15 (53%)
PTKc_c-ros 2213..2483 CDD:270640 103/279 (37%)
Abl2NP_033725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
CAP 2..106
SH3_Abl 111..164 CDD:212784
SH2_ABL 169..262 CDD:198189 21/115 (18%)
PTKc_Abl 281..543 CDD:270645 104/282 (37%)
Kinase activation loop. /evidence=ECO:0000250 427..451 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..642 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674
Nuclear localization signal. /evidence=ECO:0000255 659..661
F-actin-binding 695..930
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 765..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..858
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1059
F-actin-binding 1020..1182
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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