Protein Alignment sev and LOC100496572

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: NP_001415012.1
• Gene: LOC100496572 / 100496572
• XenbaseID: XB-GENE-29083231
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 1040
• Identity: 255/1040 - (24%)
• Similarity: 394/1040 - (37%)
• Gaps: 295/1040 - (28%)

  Fly  1588 NLVDNQGKLCVYDVARQLC---------TASALRAQLNLLGEDSIAGQLAQDSGYLYAVKNWSIR 1643
            |:...||: |..:.|:..|         ..:.||...|:    ::.|:..|.|
 Frog   528 NVCCQQGE-CEGECAQNTCLPAITDFYPKTAPLRGNTNI----TLCGRDFQSS------------ 575

  Fly  1644 AYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLP--SSGGSLLKATDCEEQRCLLH--- 1703
                       .|...|.:.::....:..:..|:.|::.|  |:..||:         |.|.
 Frog   576 -----------VVYNAPPKAKITAGTHRVSVGPRTCIVNPGKSNSTSLV---------CTLQTEG 620

  Fly  1704 LPMITASEDCPLPI----PGVRYQLNLTLAK------EPGSEEHDHGMEPL--GQWLLGAGESLN 1756
            ||...::.|..|.|    .|..|.:..|::.      ||.....:....||  |..|...|::|.
 Frog   621 LPDTASTADIALTIDENLTGTPYYIKGTISAAGFNFVEPAITSIEPNFGPLAGGTMLTLKGQNLR 685

  Fly  1757 LTDLLPFTRYRVSG---ILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVS 1818
            ..:.   .|..:||   ::|.           .|.|.|:|..              :|||.|.:.
 Frog   686 SGET---QRVFISGAECMISG-----------SLCPAEVLCC--------------VSPRSLSLG 722

  Fly  1819 WLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKP----GSGYSLWV 1879
            .|....|              |||..:....:::.....|       ::.|:|    .||..|.:
 Frog   723 PLNVSAL--------------LDGAEISSPAQFQYKPDPL-------VSVIRPNCSLASGTRLTI 766

  Fly  1880 QAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNV 1944
            |.....:.|:               :::...|..::|....||   ..|.::.|| |.|......
 Frog   767 QGSNLDSVSS---------------IKISYSGQKTVSSDCQGT---FSSDRIVCR-SPEYPYFGR 812

  Fly  1945 AGNHTKMV--VEPLQPRTRYQCRLLLGYAATPGAP---------LYHGTAEVYETLGDAPSQPGK 1998
            .||.|..:  |..:.|   |:.|.|..|...|..|         |..|..|:         :..:
 Frog   813 PGNLTLALDAVNYIYP---YRFRYLQNYVIHPFRPKDPDGGILKLKKGEDEI---------ETHQ 865

  Fly  1999 PQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIR-RRRRRRRRNSGGSLEQLPWAEEPV 2062
            ..||.:| ...:|:.|.......|..|.|        :|. |..:.....|.||:.|       |
 Frog   866 ENLEQVA-TCLKVSMTVGGRECNPTVLKN--------EITCRIPKGMVIPSEGSIVQ-------V 914

  Fly  2063 VVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLV 2127
            .|:|.    |.|..|..||..|                              :|.:      .:|
 Frog   915 CVDDD----CTTVGLVMIVNML------------------------------DPVL------GIV 939

  Fly  2128 LAIIAPAAIVSSCVLALVLVRKVQKRR----LRAKKLL-QQSRPSIWSNLSTLQTQQQL------ 2181
            |..:|...:|:  ||..:|::..:|::    :.|.:|| ..:|..:.|.:|.|....:.
 Frog   940 LGSVASVLVVA--VLIFLLLKHQRKKKKKPAVEALELLSNNNREPVLSPISLLHVDYRTSYIPSS 1002

  Fly  2182 ----MAVRNRAFS-------------TTLSDADIALLPQINWSQLKLL-----------RFLGSG 2218
                |......:|             |:|.|   :|.|::......:|           |.:|.|
 Frog  1003 NSGGMLSHGAGYSGGSLGGGSMPILLTSLLD---SLRPELLEEVKDVLIPERCLTTHRDRIIGKG 1064

  Fly  2219 AFGEVYEGQLKTEDSEEPQRVAIKSLRK--GASEFAELLQEAQLMSNFKHENIVCLVGICFDTES 2281
            .||.||.|....||.:| ...|:|||.:  ...|..|.|:|..||.:|.|.|::.|:||....|.
 Frog  1065 HFGSVYHGTYVDEDQQE-VHCAVKSLNRITDLEEVEEFLREGILMKSFHHPNVLSLIGIFLPQEG 1128

  Fly  2282 ISL-IMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLA 2345
            :.| ::..|:.|||..::|.      ||..||    :.:|:...:.|:.|..||.:..|||||||
 Frog  1129 LPLVVLPFMKHGDLRHFIRC------QERNPT----VKDLVGFGLQVSRGMEYLANRKFVHRDLA 1183

  Fly  2346 CRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY--RKEGEGLLPVRWMSPESLVDGLFTTQS 2408
            .|||::.|:.       .||:.|||||||::..:||  |:.....|||:||:.|||....|||:|
 Frog  1184 ARNCMLDETF-------HVKVADFGLARDVFDKEYYSVRRHKNARLPVKWMALESLQTQKFTTKS 1241

  Fly  2409 DVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPS 2473
            |||:||||.||::|.|..||...:.:::..::..|.||.||..|.:.||||:|.||...|.|||:
 Frog  1242 DVWSFGVLLWELMTRGAPPYPDVDPYDITRYLFRGRRLAQPEYCPDPLYSLMLSCWNPQPEERPT 1306

  Fly  2474 FRRCYNTLHAISTDLRRTQMASATADTVVSCSRPEFKVRFDGQPL-EEHREHNERPEDENLTLRE 2537
            |.:....:..||..|......:... |.|:..|        .||. ..|....:..|:||.:..|
 Frog  1307 FTQLVGDMEVISNSLCGDHYINLNV-TYVNLDR--------DQPFPPTHPPSEDELEEENSSTEE 1362

  Fly  2538  2537
             Frog  1363  1362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	17/94 (18%)
		FN3	1993..2111	CDD:238020	23/118 (19%)
		PTKc_c-ros	2213..2483	CDD:270640	109/274 (40%)
LOC100496572	NP_001415012.1	None