DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and met

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_001007125.1	Gene:	met / 100150664	ZFINID:	ZDB-GENE-041014-1	Length:	1382	Species:	Danio rerio

Alignment Length:	996	Identity:	232/996 - (23%)
Similarity:	382/996 - (38%)	Gaps:	269/996 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1642 IRAYGRRRQQLEYTVELEP--EEVRLL--QAHN---------------------YQAYPPKNCLL 1681
            :..:|:....:::.:::.|  .|:.||  |.||                     .|.:...:|||
Zfish   462 VSRFGKTEPHVDFRLDMLPVSSEMALLSPQHHNGSLLLITGDKVSKLPVIGPGCEQLWTCSSCLL 526

  Fly  1682 LPS--------SGGSLLKATDCEEQRCLLHLPMITASEDCPLPIPGV-------RYQLNLTL-AK 1730
            .|.        :.....:|..|.:.:.:        .:.|||.|..:       |.|.|:|: .|
Zfish   527 APGFMGCGWCRTSNRCTRAPRCPQSQWI--------QDSCPLLITSISPSSAPLRGQTNITICGK 583

  Fly  1731 EPGSEEHDHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVL-------A 1788
            ..|..:.|.             ....|.|::      |:|......:|......||.       :
Zfish   584 NFGFNKKDR-------------FDTKLVDVV------VAGTKCKLERKDSNNNRLVCGLDYVNWS 629

  Fly  1789 PLE-LLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWE 1852
            .|: ::|..:.....:......::|..:|:  .|....:|.....|:. ...||..|||
Zfish   630 SLDSVITVRSGKEQAQKDGFSFVNPVIIEI--FPEFGPQSGGTMLTIS-GSFLDSGNVQ------ 685

  Fly  1853 AHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRS-FAELPELQLLELGPYSLS 1916
                 ..|.|..... ::..|...|..:....|:.|....:||:.. ..|.|           :|
Zfish   686 -----TVTVGNATCV-LQSVSATMLTCRTPPQPSPSQHKVQLHIDGVIFEAP-----------VS 733

  Fly  1917 LTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMV-----VEPLQPRTRYQCRLLLGYAATPGA 1976
            .|:...|.         .||.:.....::|..|..|     ...|||:       ::..|||.|
Zfish   734 YTYNKNPH---------ISSVQPKHSFISGGSTVTVNGFYLHSALQPQ-------MVLTAATEG- 781

  Fly  1977 PLYHGTAEVYE----TLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNL--------E 2029
            .|:..|....|    .|...||..|......:|.::..|.      :|.....|:|        |
Zfish   782 KLFQVTCSHDEDKRNILCITPSLKGLSVQPPVATKMTFVL------DGFSTDQYDLLYVEDPKFE 840

  Fly  2030 ALQARSDIRRRRRRRRRNSGGSLE-QLPWAEEPVVVEDQWLDFCNTT--ELSCIVKSLHSSRLLL 2091
            ..|..:...|.::       ..|| ::|...:..|...:.|...|.|  .::.:..:|..:..:.
Zfish   841 EFQKPTVTPRGKK-------NILEIKVPPVNQEAVKNGEVLRVSNRTCESVTLVGNTLECTVPME 898

  Fly  2092 FRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLA-------IIAPAAIVSSCVLALVLVRK 2149
            .:..|:.||..|           :...|....|.::||       :|.....||..:|.|:.|..
Zfish   899 LQTAAKELEVEW-----------KQATSSVILGRVILAQDQDYRILITGGVCVSILLLLLIAVFV 952

  Fly  2150 VQKRRLRAKKLLQQSRPSIW-------------SNLSTLQTQQQLMAVRNRAFSTTL-------- 2193
            ..||:   |.:...::..:|             :|..::....::::..:..:.|||
Zfish   953 WIKRK---KHIDDLAKTMVWYDGRAHIPHLDMLANARSVSPTDEMVSHESVDYRTTLLEDQNLPL 1014

  Fly  2194 ------------------------SDADIA--LLPQ---INWSQL--KLLR-------------- 2213
                                    .:.|:|  |||.   |:...|  :||:
Zfish  1015 SQTESCRPHLYAHSHVDLSPMLGPMEGDLASPLLPSTAPIDLGSLHPELLKXVQHVVIAREDLLL 1079

  Fly  2214 ----FLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRK--GASEFAELLQEAQLMSNFKHENIVCL 2272
                .:|.|.||.|:.|.|...|.:: |..|||||.:  ...|.::.|:|..::.:|.|.|::.|
Zfish  1080 HVNEIIGRGHFGCVFHGTLLEPDGQK-QHCAIKSLNRITDIEEVSQFLKEGIIVKDFSHPNVLSL 1143

  Fly  2273 VGICFDTESISL-IMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLED 2336
            :|||..:|...| ::.:|:.|||.:::|      .:...||    :.:|:...:.||.|..||..
Zfish  1144 LGICLPSEGSPLVVLPYMKHGDLRNFIR------DESHNPT----VKDLMGFGLQVAKGMEYLAS 1198

  Fly  2337 MHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY---RKEGEGLLPVRWMSPES 2398
            ..|||||||.|||::.||       .|||:.|.|||||:|..:||   .|.|. .|||:||:.||
Zfish  1199 KKFVHRDLAARNCMLDES-------YTVKVADVGLARDVYDKEYYSVHNKHGV-KLPVKWMALES 1255

  Fly  2399 LVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLC 2463
            |....|||:||||:||||.||::|.|..||:..|:|::...:.:|.||.||..|.:.||::::.|
Zfish  1256 LQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYNVMIEC 1320

  Fly  2464 WRTDPWERPSFRRCYNTLHAI 2484
            |...|..||:|....:.:.||
Zfish  1321 WHPKPERRPTFLELVSRISAI 1341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	18/97 (19%)
		FN3	1993..2111	CDD:238020	23/128 (18%)
		Pkinase_Tyr	2209..2481	CDD:285015	109/297 (37%)
		PTKc_c-ros	2213..2483	CDD:270640	106/293 (36%)
met	NP_001007125.1	Sema_MET_like	43..511	CDD:200509	8/48 (17%)
		PSI	514..559	CDD:214655	7/52 (13%)
		IPT	562..653	CDD:301692	17/109 (16%)
		IPT_plexin_repeat2	654..736	CDD:238584	21/107 (20%)
		IPT	740..823	CDD:301692	22/105 (21%)
		Pkinase_Tyr	1079..1338	CDD:285015	106/277 (38%)
		PTKc_Met_Ron	1083..1344	CDD:270649	108/278 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810