DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sev and malrd1

DIOPT Version :9

Sequence 1:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster
Sequence 2:	NP_001274478.1	Gene:	malrd1 / 100148465	ZFINID:	ZDB-GENE-140106-257	Length:	1793	Species:	Danio rerio

Alignment Length:	1465	Identity:	264/1465 - (18%)
Similarity:	406/1465 - (27%)	Gaps:	614/1465 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WQQNVDHQSDEQD-KQAKGAAPTKRLNISFNVKIAVNVNTKMTTTHINQQAPG--TSSSSSNSQN 66
            |.|  ||:.|..| ...:|..||              .||.....|....|.|  ....||:.|.
Zfish   490 WTQ--DHEEDMFDWTHIQGPTPT--------------FNTGPWKDHTRASADGHFLYIESSDPQK 538

  Fly    67 ASPSKIVVRQQSSSFDLR------------------QQLARLGRQLASGQDGHGGI--------- 104
            ...:.:::.|.......|                  |.:..|...:.:...|.|.:
Zfish   539 FKDTAVLISQPFLPTPRRGPEPKPPCVFRFHYHMFGQHVFCLAVYMRTSNSGRGNLLWVRYGDQG 603

  Fly   105 ----STILIINLLLLILLSICCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAI---- 161
                .|||.||              .||::.:             |:...:..|....:||
Zfish   604 NFWHRTILEIN--------------SSHHFQI-------------LVEGTVGDDFRGDIAIDDLS 641

  Fly   162 ------WHKHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDC 220
                  :........||       :|.|..|::..|            .|.......:...||:|
Zfish   642 FYGCQSYEGELPLEEPS-------TSAPVPTLSTAP------------SHSCPPDQFVCLTTREC 687

  Fly   221 V---QRCIVEEDLFLDEFGIQCEKADNGEKCYKTRCT---KGCAQWYRALKELESCQEACLSLQF 279
            |   |.|         :|...|..:.:.|.|.|..|.   .....||  |.|:.
Zfish   688 VNLSQVC---------DFRPDCSDSSDEELCVKEYCDFEGDSLCGWY--LSEIP----------- 730

  Fly   280 YPYDMPCIGACEMAQRDYWHL-QRLAISHLVERTQPQLERAPRADGQSTPLTIRWAMHFPEHYLA 343
             |:...            |.. |.|:|.|..|:.:|..:.               .:..||.:
Zfish   731 -PHAFS------------WQTGQGLSIHHGEEKHRPANDH---------------TLGSPEGW-- 765

  Fly   344 SRPFNIQYQFVDH----HGEELDLEQEDQDASG-ETGSSAWFNLADYDCDEYYVCEILEALIPYT 403
                   |.|||.    :|...||.......:| :.....|::::.:......|. |....:.|.
Zfish   766 -------YVFVDSSNGGYGHTTDLLTAPIKITGPQCTLEFWYHMSGFTVGSLQVL-IKSGAVAYE 822

  Fly   404 QY-------------------RFRFELPFGENR----------DEVLYSPATPAYQTP------- 432
            .:                   |...::.....|          |:|.:....|...:.
Zfish   823 VWSQSGSQGNSWRRGEVFIGIRHNIQVVLRAKRGISYMGDVVVDDVAFVDCAPPVMSDLPCQNNE 887

  Fly   433 ---PEGAPIS----APVIEHL-MGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSE--------GN 481
               ..|..|:    ...|:|. .|.|::|.......|| .|...:....|.|..:        ||
Zfish   888 FICANGHCINEANLCDFIDHCGDGSDENHYICKGFSGR-CNFEFDLCSWRQSQDDDFDWLIKPGN 951

  Fly   482 ATSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGEGPVAKG-FVQT--HSARNEKP-----AK 538
            ..:..:.|:             |::||.    |..|.....:| |.||  |:||...|     :|
Zfish   952 MNTHGIGPS-------------TDHTLR----NPSGHYLYLEGSFPQTTGHTARIFGPLFRRCSK 999

  Fly   539 DLTESVLLVGRRAVMWQSLEPAGENSM-IYQSQEELADIAWSKREQQLWLLNVHGELRSLKFESG 602
            |.         :.|.:..:...|..:: :|.|......:          |||:.|
Zfish  1000 DC---------KMVFYVHMSGDGIGTLNVYMSSNSSNSL----------LLNLIG---------- 1035

  Fly   603 QMVSPAQQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAMESPERNQSSFQIISTDLLGESTQKVG 667
                       :.||..|.:.||...|.|:   |:.|  |......:...|...|:...|...:.
Zfish  1036 -----------NQGNYWSRQEVPLASSDDF---RIMF--EGKVGRNTGVHICLDDITFSSDCILS 1084

  Fly   668 ESFD---------LPVEQLEVDALNGWIFWRNEESLWRQDL----------------HGRMIHRL 707
            .:|:         .|...|:.|  ||..:...::..:..|.                |||.
Zfish  1085 NTFEKESRLLTGSCPSGSLQCD--NGNCYKPEQKCDFTDDCEDGTDELECGTSCSFEHGRC---- 1143

  Fly   708 LRIRQPGWFLVQPQHF-------IIHLMLPQEGKFLEISYDGGFKHPLPLPPPSNGAGNGPASSH 765
                  ||.......|       .||::.|.....||                 |..||
Zfish  1144 ------GWKSSLAGTFSWALGVGSIHMIRPPHDHTLE-----------------NEIGN------ 1179

  Fly   766 WQSFALLGRSLLLPDSGQLILVEQQGQAASPSASWPLKNLPDCWAVILLVPESQPLTSAGGKPHS 830
               |..|                    ||:|..   ||                     |.|.|.
Zfish  1180 ---FVYL--------------------AATPVG---LK---------------------GDKAHM 1197

  Fly   831 LKALLGAQAAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDN 895
            ..::         ||:      .||....::.|.:      |:.|          .|:.||
Zfish  1198 RSSV---------WKQ------TSATCKLAFWYYI------SEKA----------TGIIRL---- 1227

  Fly   896 LYQLRVRAINVDGEPGE-WTEPLAARTWPLGPHRLRWASRQGSV--------------IHTNELG 945
                   .|..:.|..| |||....|.|           |:..|              :.|.::.
Zfish  1228 -------FIKTENELREVWTERQMHREW-----------RRAEVSLKNLRNFILIFEAVRTRDVS 1274

  Fly   946 EGLEVQQEQL------ERLPGPMTMV-------NESVGYYVTGDGLLHCINLVHSQWGCPISEPL 997
            .|..:...|.      ...||....:       .:.:.|::..||...|.: ...:..|     |
Zfish  1275 GGAALDDLQFIDCAPQAVSPGSCPAITDFLCNNGDCIEYHLECDGKADCSD-ESDEIDC-----L 1333

  Fly   998 QHVGSVTYDWRGGRVYWTDLARNCVVRMDPWSGSRELLPVFEANFLALDPRQGHLYYATSSQLSR 1062
            ...|:..:|...|  :|.|:   |.:..||                 .|..:..:.|.|   ::.
Zfish  1334 NVPGACNFDMPSG--HWEDI---CHLSQDP-----------------NDDFKWDIGYGT---ING 1373

  Fly  1063 HGSTPDEAVT------YYRVNG-LEGSIASFVLDTQQD---------QLFWL-VKGS---GALRL 1107
            .|.:.|.:.:      |...:| .||.|||.:  |||:         ..||. :.||   |||::
Zfish  1374 TGPSADHSPSGAGGFLYVNASGRREGDIASLL--TQQEFPASVGICHLRFWFHMYGSHHMGALKV 1436

  Fly  1108 YR-----APL----TAG--GDSLQMIQQIKGVFQAVPDSLQLLRPLGALLWLERS------GRRA 1155
            |.     |||    |.|  ||.......|  :..|.|..:.:...:||..|.:.:      .|:.
Zfish  1437 YTVGRSGAPLLMWATCGNHGDGWHYANVI--LSNASPFKVSIQAVVGADKWTDIAVDDFSFTRQC 1499

  Fly  1156 RLVRLAAPL--------------------------DVMELPTPDQASPASALQLLDPQPLPPR-- 1192
            .|.....|:                          :|..|...|:...||.|    |..:||:
Zfish  1500 LLGGPVTPIPQTCHIEHFQCLYLFECIPLSWHCDGEVDCLDHSDEEKCASVL----PGTVPPQTG 1560

  Fly  1193 ---------DEGVIPMTVLPDSVRLD--DGHWDDF 1216
                     |...||..:..||| ||  ||. |::
Zfish  1561 CETGEYQCMDSSCIPALLRCDSV-LDCPDGE-DEY 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:278470	18/93 (19%)
		FN3	826..921	CDD:238020	18/95 (19%)
		LY	993..1026	CDD:214531	7/32 (22%)
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020
		Pkinase_Tyr	2209..2481	CDD:285015
		PTKc_c-ros	2213..2483	CDD:270640
malrd1	NP_001274478.1	LDLa	22..56	CDD:238060
		MAM	62..215	CDD:279023
		MAM	62..215	CDD:99706
		LDLa	232..266	CDD:238060
		MAM	270..432	CDD:279023
		MAM	270..429	CDD:99706
		LDLa	441..475	CDD:238060
		MAM	481..642	CDD:279023	34/194 (18%)
		MAM	481..642	CDD:99706	34/194 (18%)
		LDLa	674..709	CDD:238060	9/43 (21%)
		MAM	714..861	CDD:99706	29/197 (15%)
		MAM	714..856	CDD:279023	28/192 (15%)
		LDLa	883..916	CDD:238060	6/32 (19%)
		MAM	926..1081	CDD:279023	42/216 (19%)
		MAM	926..1081	CDD:99706	42/216 (19%)
		LDLa	1098..1132	CDD:238060	6/35 (17%)
		MAM	1136..1298	CDD:279023	49/294 (17%)
		MAM	1136..1297	CDD:99706	49/293 (17%)
		LDLa	1297..1332	CDD:238060	4/35 (11%)
		MAM	1339..1496	CDD:279023	43/185 (23%)
		MAM	1339..1496	CDD:99706	43/185 (23%)
		LDLa	1512..1547	CDD:238060	3/34 (9%)
		LDLa	1561..1595	CDD:238060	11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900