Protein Alignment sev and mst1rb

DIOPT Version :10

• Sequence 1: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Sequence 2: XP_073773053.1
• Gene: mst1rb / 100134855
• ZFINID: ZDB-GENE-071218-3
• Length: 1374
• Species: Danio rerio
• Alignment Length: 856
• Identity: 213/856 - (24%)
• Similarity: 330/856 - (38%)
• Gaps: 236/856 - (27%)

  Fly  1835 HWQQEL---------------DGENVQDRREWE------------AHERRL-ETA---------G 1862
            ||..|.               ||::......||            .||.|| |||         .
Zfish   546 HWVNESCPPVITEFFPKTAPPDGQSEMTLCGWEFQSPLRPAITTRTHEVRLGETACVVQPHKSNC 610

  Fly  1863 THRLTGIKPGSGYSLWVQAHATPTKSNSSERLH--VRSFAELP----------ELQ--------- 1906
            ||.|..|:.|:..:|:...:.|..........|  :...||:|          |:|
Zfish   611 THLLCKIRSGTIETLFKPLNVTAKVHEGQVEGHYSIDGSAEMPGFTFVVPNITEVQPDYGPVDGG 675

  Fly  1907 -LLEL-GPY-----SLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQC 1964
             |:.: |||     :..:|..|...|:.|:             :||..:...:|...||.|..:.
Zfish   676 TLITITGPYLDSGKNRKVTLDGESCPVQSV-------------SVARGNLSSIVCLSQPVTEVKD 727

  Fly  1965 RLLLGY-----AATPGAPLYHGTAEVYETLGDAPSQPG--------------------KPQLEHI 2004
            .:|..|     ..|.....|..|.|:...|.|.....|                    :|:..|:
Zfish   728 VVLRVYIDKSRVVTTKVFRYKKTPEILAVLPDCSFDSGSRIIIEGRNLDSVYRTVVYFQPKESHL 792

  Fly  2005 AEEVFRVTWTAARGNGAPIALYNLEALQARSDIRR-----------------------RRRRRRR 2046
                 :...|..||...|..:..:..:..|.:...                       .|.....
Zfish   793 -----KPVSTECRGKAKPTRMECITPVFPRDETEEGELSFDMDGVLGLWKHDFSYHPYGRPIPFE 852

  Fly  2047 NSGGSLEQLPWAEEPVVVEDQWLDFCNT-------------------TELSCIVKS--LHSSRLL 2090
            ..|..|...|..:| |.:..|.|:..::                   .|::|.:.:  ...|..|
Zfish   853 TEGHILRLYPGFDE-VSLHHQKLNLVSSCMSITMTVGDVDCGGKVLDNEITCRIPNNLTIPSEGL 916

  Fly  2091 LFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRL 2155
            ..:|......|..|...         .||......:||.|:  ||:|:..|||.::::.::|:
Zfish   917 PVKVTVNGYTHNVGTVI---------LVSNHYMVGIVLGIL--AALVTGAVLAFIVLKNLRKQ-- 968

  Fly  2156 RAKKLLQ-QSRPSIWSN---------------------LSTLQTQQQLMAVRNRAFSTTLSDADI 2198
              ||..| ::|.|.:|:                     |:::......:|....|::.||.....
Zfish   969 --KKASQTENRLSYFSHSRSRSNSVDLSSLVDYRRDLPLTSITAPTGALAFPGLAYTGTLDTTLT 1031

  Fly  2199 ALLPQINWS----QLKLL------------------RFLGSGAFGEVYEGQLKTEDSEEPQRVAI 2241
            .|:|..|.|    :.:||                  :.:|.|.||.||.|.| |:.:......|:
Zfish  1032 PLMPPENISITSFRPELLEEVKDVLIPASTLKVHHHQIIGKGHFGTVYHGYL-TDHNNREIHCAV 1095

  Fly  2242 KSLRK--GASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISL-IMEHMEAGDLLSYLRAARA 2303
            |||.:  ...|..:.|:|..||..|.|.|::.|:||....|.:.| ::.:|:.|||..::|.
Zfish  1096 KSLNRITDVEEVEQFLKEGILMKGFHHSNVLSLLGILLPEEGLPLVVLPYMKHGDLRHFIRC--- 1157

  Fly  2304 TSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGD 2368
               :...||    :.:|:...:.||.|..||....|||||||.|||::.||       .|||:.|
Zfish  1158 ---ENRNPT----VKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDES-------YTVKVAD 1208

  Fly  2369 FGLARDIYKSDYY--RKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAAR 2431
            ||:|||:.:.:||  :...:..|||:||:.|||....|||:||||:||||.||:||.|..||...
Zfish  1209 FGMARDVLEKEYYSVQDHRKAKLPVKWMAIESLQTQKFTTKSDVWSFGVLMWEMLTRGASPYPEV 1273

  Fly  2432 NNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASA 2496
            :.::|...:.:|.||.||..|.:.|:::||.||..||.:||||....:.:.:|.:.|......|.
Zfish  1274 DPYDVTHFLLKGRRLPQPQYCPDPLFAILLQCWDPDPEKRPSFSTLVSAVMSILSSLEGEHYISL 1338

  Fly  2497 TADTVVSCSRP 2507
            .. |.|:..:|
Zfish  1339 KV-TYVNLDQP 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	21/92 (23%)
		FN3	1993..2111	CDD:238020	23/181 (13%)
		PTKc_c-ros	2213..2483	CDD:270640	106/274 (39%)
mst1rb	XP_073773053.1	None