DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-4 and ZMYND15

DIOPT Version :9

Sequence 1:	NP_572675.1	Gene:	SmydA-4 / 32034	FlyBaseID:	FBgn0030257	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001254751.1	Gene:	ZMYND15 / 84225	HGNCID:	20997	Length:	750	Species:	Homo sapiens

Alignment Length:	400	Identity:	89/400 - (22%)
Similarity:	128/400 - (32%)	Gaps:	112/400 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 YRVEHSD----IYG--RYLVAN------------RQLEAGETLIREEP----LAIGPCVSGDPVC 91
            ||.|..|    ::|  |..||.            |||||....:.::|    |.:.|
Human     7 YRDEFLDFTALLFGWFRKFVAERGAVGTSLEGRCRQLEAQIRRLPQDPALWVLHVLP-------- 63

  Fly    92 LGCYHPVSLKADQYRCP------GCAWPLCGSTCAGLKH-------------RHGHTETECQLYA 137
               .|.|.:...|...|      |.||.|..:....|:.             ..|..|.|.....
Human    64 ---NHSVGISLGQGAEPGPGPGLGTAWLLGDNPPLHLRDLSPYISFVSLEDGEEGEEEEEEDEEE 125

  Fly   138 ERRAVAGELLTERAGPAEVRDLYELVMIVRILLLRQHDPEQFALIAR-----MESHTEERRQNAV 197
            |:|...|...||:..|.|.|   ||....|......:.|.:....||     .:...|:|.:|..
Human   126 EKREDGGAGSTEKVEPEEDR---ELAPTSRESPQETNPPGESEEAAREAGGGKDGCREDRVENET 187

  Fly   198 LWRHYEEKVVQRLRVTWQLEDLEAEQVHEVC---------GILDVNCFEIGQNGAKA-----RTL 248
               ..:::..||         .||..:|..|         .||.::....|..|..:     :.|
Human   188 ---RPQKRKGQR---------SEAAPLHVSCLLLVTDEHGTILGIDLLVDGAQGTASWGSGTKDL 240

  Fly   249 YPSAF-LLAHDCTPNTAHTDDPSSFEILLRTSRRVREREALTLSYAYTLQGTLKRRAFMHEGKLF 312
            .|.|: ||.|.........|.....::.:..:|..||.|:|.......|..|..|......|..|
Human   241 APWAYALLCHSMACPMGSGDPRKPRQLTVGDARLHRELESLVPRLGVKLAKTPMRTWGPRPGFTF 305

  Fly   313 ------WC-CCRRCSDPRELG--TDCSALVCATCRTGSVRAVDPLQQTGDWACDRC----AHKMG 364
                  .| .|.|.|...:|.  ..|||::  .|....:||        ||  .||    :|:..
Human   306 ASLRARTCHVCHRHSFEAKLTPCPQCSAVL--YCGEACLRA--------DW--QRCPDDVSHRFW 358

  Fly   365 ATEVERQLDR 374
            ...:...::|
Human   359 CPRLAAFMER 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-4	NP_572675.1	None
ZMYND15	NP_001254751.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..199		22/104 (21%)
		zf-MYND	313..359	CDD:280009	16/57 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..590
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900