Protein Alignment SmydA-4 and SMYD3

DIOPT Version :10

• Sequence 1: NP_572675.1
• Gene: SmydA-4 / 32034
• FlyBaseID: FBgn0030257
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_001161212.1
• Gene: SMYD3 / 64754
• HGNCID: 15513
• Length: 428
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 111/498 - (22%)
• Similarity: 175/498 - (35%)
• Gaps: 147/498 - (29%)

  Fly    58 GRYLVANRQLEAGETLIREEPLAIGPCV-SGDPVCLGCYHPVSLKADQYRCPGC----------- 110
            |..|.|...|..||.|.|.:|||...|. |...||..|   :..|....||..|
Human    15 GNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRC---LLGKEKLMRCSQCRVAKYCSAKCQ 76

  Fly   111 --AWPLCGSTCAGLKHRHGHTETECQLYAERRAVAGELLTERAGPAEVRDLYELVMIVRILLLRQ 173
              |||.....|..||        .|:              .|..|..||.|..:|.  :::....
Human    77 KKAWPDHKRECKCLK--------SCK--------------PRYPPDSVRLLGRVVF--KLMDGAP 117

  Fly   174 HDPEQFALIARMESH----TEER----RQNAVLWRHYEEKVVQ---RLRVTWQLEDLEAEQVHEV 227
            .:.|:......:||:    ||::    ||..:.::|:..:.:|   :|...:.|.:..|:.:...
Human   118 SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNS 182

  Fly   228 CGILDVNCFEIGQNGAKARTLYPSAFLLAHDCTPNTAHT-DDPSSFEILLRTSRRVREREALTLS 291
            ..|.:....|:|..      ||||..||.|.|.||.:.. :.|   .:|||..|.:...|.||:.
Human   183 FTICNAEMQEVGVG------LYPSISLLNHSCDPNCSIVFNGP---HLLLRAVRDIEVGEELTIC 238

  Fly   292 YAYTLQGTLKRRAFMHEGKLFWCCCRRCSDPRELGTDCSALVCATCRTGSVRAVDPLQQTGD--- 353
            |...|..:.:||..:.:...|.|.|.||....:   |...|                  |||
Human   239 YLDMLMTSEERRKQLRDQYCFECDCFRCQTQDK---DADML------------------TGDEQV 282

  Fly   354 WACDRCAHKMGATEVERQLDRINNDLEDIDVHDIPGLENFLLRYRDVLRPNHYLLLSAKYSLCQI 418
            |           .||:..|.:|    |::..|         .::..||            ::||.
Human   283 W-----------KEVQESLKKI----EELKAH---------WKWEQVL------------AMCQA 311

  Fly   419 YGRTEGYLLP-----QMSPEDIAR---------KES--YCREFLEIVDVLDPGLTRLRGL-IM-- 464
            ...:....||     |:...|.|.         :|:  |....:|...:..||...:||: :|
Human   312 IISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKV 376

  Fly   465 --YELHAPVMVLAQS----AFQSGQISRQEFQRRLKEVVKLLQ 501
              .:||..:...|..    ||...:::.......:::::.||:
Human   377 GKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLE 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-4	NP_572675.1	SET_SMYD	<230..319	CDD:380997	28/89 (31%)
SMYD3	NP_001161212.1	SET_SMYD3	5..268	CDD:380980	75/288 (26%)
		zf-MYND	49..87	CDD:460312	9/40 (23%)
		C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000269|PubMed:25738358	272..428		36/202 (18%)